8KCI

ATP-bound hMRP5 outward-open

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005768	cellular_component	endosome
A	0005794	cellular_component	Golgi apparatus
A	0005796	cellular_component	Golgi lumen
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006855	biological_process	xenobiotic transmembrane transport
A	0008514	molecular_function	organic anion transmembrane transporter activity
A	0008559	molecular_function	ABC-type xenobiotic transporter activity
A	0010008	cellular_component	endosome membrane
A	0015216	molecular_function	purine nucleotide transmembrane transporter activity
A	0015232	molecular_function	heme transmembrane transporter activity
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0015865	biological_process	purine nucleotide transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0022884	molecular_function	macromolecule transmembrane transporter activity
A	0030213	biological_process	hyaluronan biosynthetic process
A	0034634	molecular_function	glutathione transmembrane transporter activity
A	0034775	biological_process	glutathione transmembrane transport
A	0035351	biological_process	heme transmembrane transport
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0043225	molecular_function	ATPase-coupled inorganic anion transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0070730	biological_process	cAMP transport
A	0070731	biological_process	cGMP transport
A	0098656	biological_process	monoatomic anion transmembrane transport
A	0098838	biological_process	folate transmembrane transport
A	0140115	biological_process	export across plasma membrane
A	0140359	molecular_function	ABC-type transporter activity
A	0150104	biological_process	transport across blood-brain barrier
A	1901505	molecular_function	carbohydrate derivative transmembrane transporter activity
A	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISLARAL

Chain	Residue	Details
A	LEU685-LEU699
A	PHE1330-LEU1344

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	260
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	280
Details	Domain: {"description":"ABC transmembrane type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	234
Details	Domain: {"description":"ABC transporter 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---