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8KBX

Cryo-EM structure of human ATG2A-WIPI4 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000407cellular_componentphagophore assembly site
A0000422biological_processautophagy of mitochondrion
A0000425biological_processpexophagy
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006914biological_processautophagy
A0008289molecular_functionlipid binding
A0009267biological_processcellular response to starvation
A0019901molecular_functionprotein kinase binding
A0030674molecular_functionprotein-macromolecule adaptor activity
A0032266molecular_functionphosphatidylinositol-3-phosphate binding
A0034045cellular_componentphagophore assembly site membrane
A0034497biological_processprotein localization to phagophore assembly site
A0044804biological_processnucleophagy
A0061723biological_processglycophagy
A0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
A1901981molecular_functionphosphatidylinositol phosphate binding
A2000786biological_processpositive regulation of autophagosome assembly
B0000045biological_processautophagosome assembly
B0000407cellular_componentphagophore assembly site
B0000422biological_processautophagy of mitochondrion
B0000425biological_processpexophagy
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005811cellular_componentlipid droplet
B0006869biological_processlipid transport
B0006914biological_processautophagy
B0010508biological_processpositive regulation of autophagy
B0016020cellular_componentmembrane
B0032266molecular_functionphosphatidylinositol-3-phosphate binding
B0034045cellular_componentphagophore assembly site membrane
B0034727biological_processpiecemeal microautophagy of the nucleus
B0043495molecular_functionprotein-membrane adaptor activity
B0044232cellular_componentorganelle membrane contact site
B0061709biological_processreticulophagy
B0061723biological_processglycophagy
B0061908cellular_componentphagophore
B0120009biological_processintermembrane lipid transfer
B0120013molecular_functionlipid transfer activity
B2000786biological_processpositive regulation of autophagosome assembly
Functional Information from PROSITE/UniProt
site_idPS00059
Number of Residues15
DetailsADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEqKGLtgavGgvI
ChainResidueDetails
BGLY1876-ILE1890

site_idPS00862
Number of Residues34
DetailsOX2_COVAL_FAD Oxygen oxidoreductases covalent FAD-binding site. PpvetaliNqrDLadaLldterslre...LaqpSGGH
ChainResidueDetails
BPRO1271-HIS1304

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues33
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues44
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues36
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues41
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues39
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues39
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues45
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues3
DetailsMotif: {"description":"L/FRRG motif","evidences":[{"source":"UniProtKB","id":"Q9Y4P8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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