8K9M
SARS-CoV-2 spike protein in complex with two S2H5 Fabs on NTD-1 and NTD-3
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| B | TYR197-HIS203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| E | SER685 | |
| C | SER685 | |
| D | SER685 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| E | ARG815 | |
| C | ARG815 | |
| D | ARG815 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN17 | |
| E | ASN1158 | |
| E | ASN1173 | |
| C | ASN17 | |
| C | ASN1158 | |
| C | ASN1173 | |
| D | ASN17 | |
| D | ASN1158 | |
| D | ASN1173 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN61 | |
| C | ASN1074 | |
| D | ASN61 | |
| D | ASN122 | |
| D | ASN717 | |
| D | ASN801 | |
| D | ASN1074 | |
| E | ASN122 | |
| E | ASN717 | |
| E | ASN801 | |
| E | ASN1074 | |
| C | ASN61 | |
| C | ASN122 | |
| C | ASN717 | |
| C | ASN801 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN74 | |
| E | ASN149 | |
| E | ASN1194 | |
| C | ASN74 | |
| C | ASN149 | |
| C | ASN1194 | |
| D | ASN74 | |
| D | ASN149 | |
| D | ASN1194 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN165 | |
| C | ASN331 | |
| C | ASN343 | |
| C | ASN616 | |
| C | ASN657 | |
| C | ASN1098 | |
| D | ASN165 | |
| D | ASN282 | |
| D | ASN331 | |
| D | ASN343 | |
| D | ASN616 | |
| E | ASN282 | |
| D | ASN657 | |
| D | ASN1098 | |
| E | ASN331 | |
| E | ASN343 | |
| E | ASN616 | |
| E | ASN657 | |
| E | ASN1098 | |
| C | ASN165 | |
| C | ASN282 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN234 | |
| E | ASN709 | |
| C | ASN234 | |
| C | ASN709 | |
| D | ASN234 | |
| D | ASN709 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| E | THR323 | |
| C | THR323 | |
| D | THR323 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| E | SER325 | |
| C | SER325 | |
| D | SER325 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN603 | |
| C | ASN603 | |
| D | ASN603 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| E | THR676 | |
| E | THR678 | |
| C | THR676 | |
| C | THR678 | |
| D | THR676 | |
| D | THR678 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| E | ASN1134 | |
| C | ASN1134 | |
| D | ASN1134 |
