8K6Z

NMR structure of human leptin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001525	biological_process	angiogenesis
A	0001542	biological_process	ovulation from ovarian follicle
A	0001666	biological_process	response to hypoxia
A	0001819	biological_process	positive regulation of cytokine production
A	0001890	biological_process	placenta development
A	0001932	biological_process	regulation of protein phosphorylation
A	0001934	biological_process	positive regulation of protein phosphorylation
A	0001936	biological_process	regulation of endothelial cell proliferation
A	0002021	biological_process	response to dietary excess
A	0003300	biological_process	cardiac muscle hypertrophy
A	0003677	molecular_function	DNA binding
A	0005102	molecular_function	signaling receptor binding
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006111	biological_process	regulation of gluconeogenesis
A	0006112	biological_process	energy reserve metabolic process
A	0006114	biological_process	glycerol biosynthetic process
A	0006629	biological_process	lipid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0006909	biological_process	phagocytosis
A	0007165	biological_process	signal transduction
A	0007565	biological_process	female pregnancy
A	0007584	biological_process	response to nutrient
A	0007623	biological_process	circadian rhythm
A	0008203	biological_process	cholesterol metabolic process
A	0008206	biological_process	bile acid metabolic process
A	0008217	biological_process	regulation of blood pressure
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008340	biological_process	determination of adult lifespan
A	0008343	biological_process	adult feeding behavior
A	0009062	biological_process	fatty acid catabolic process
A	0009892	biological_process	negative regulation of metabolic process
A	0010507	biological_process	negative regulation of autophagy
A	0010888	biological_process	negative regulation of lipid storage
A	0014823	biological_process	response to activity
A	0019222	biological_process	regulation of metabolic process
A	0019953	biological_process	sexual reproduction
A	0021954	biological_process	central nervous system neuron development
A	0030073	biological_process	insulin secretion
A	0030217	biological_process	T cell differentiation
A	0030300	biological_process	regulation of intestinal cholesterol absorption
A	0031667	biological_process	response to nutrient levels
A	0032008	biological_process	positive regulation of TOR signaling
A	0032099	biological_process	negative regulation of appetite
A	0032310	biological_process	prostaglandin secretion
A	0032355	biological_process	response to estradiol
A	0032735	biological_process	positive regulation of interleukin-12 production
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0032757	biological_process	positive regulation of interleukin-8 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0032814	biological_process	regulation of natural killer cell activation
A	0032817	biological_process	regulation of natural killer cell proliferation
A	0032868	biological_process	response to insulin
A	0032869	biological_process	cellular response to insulin stimulus
A	0033197	biological_process	response to vitamin E
A	0033210	biological_process	leptin-mediated signaling pathway
A	0033686	biological_process	positive regulation of luteinizing hormone secretion
A	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
A	0035556	biological_process	intracellular signal transduction
A	0035630	biological_process	bone mineralization involved in bone maturation
A	0035904	biological_process	aorta development
A	0038108	biological_process	negative regulation of appetite by leptin-mediated signaling pathway
A	0042102	biological_process	positive regulation of T cell proliferation
A	0042269	biological_process	regulation of natural killer cell mediated cytotoxicity
A	0042307	biological_process	positive regulation of protein import into nucleus
A	0042445	biological_process	hormone metabolic process
A	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
A	0042593	biological_process	glucose homeostasis
A	0042755	biological_process	eating behavior
A	0043066	biological_process	negative regulation of apoptotic process
A	0043270	biological_process	positive regulation of monoatomic ion transport
A	0043410	biological_process	positive regulation of MAPK cascade
A	0044320	biological_process	cellular response to leptin stimulus
A	0045471	biological_process	response to ethanol
A	0045598	biological_process	regulation of fat cell differentiation
A	0045765	biological_process	regulation of angiogenesis
A	0045906	biological_process	negative regulation of vasoconstriction
A	0046325	biological_process	negative regulation of glucose import
A	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
A	0046628	biological_process	positive regulation of insulin receptor signaling pathway
A	0046850	biological_process	regulation of bone remodeling
A	0046881	biological_process	positive regulation of follicle-stimulating hormone secretion
A	0046890	biological_process	regulation of lipid biosynthetic process
A	0048639	biological_process	positive regulation of developmental growth
A	0050796	biological_process	regulation of insulin secretion
A	0050810	biological_process	regulation of steroid biosynthetic process
A	0050892	biological_process	intestinal absorption
A	0050901	biological_process	leukocyte tethering or rolling
A	0050999	biological_process	regulation of nitric-oxide synthase activity
A	0051428	molecular_function	peptide hormone receptor binding
A	0051541	biological_process	elastin metabolic process
A	0051726	biological_process	regulation of cell cycle
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0060587	biological_process	regulation of lipoprotein lipid oxidation
A	0060612	biological_process	adipose tissue development
A	0061037	biological_process	negative regulation of cartilage development
A	0070093	biological_process	negative regulation of glucagon secretion
A	0071298	biological_process	cellular response to L-ascorbic acid
A	0071300	biological_process	cellular response to retinoic acid
A	0090335	biological_process	regulation of brown fat cell differentiation
A	0097009	biological_process	energy homeostasis
A	0098868	biological_process	bone growth
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1900015	biological_process	regulation of cytokine production involved in inflammatory response
A	1900180	biological_process	regulation of protein localization to nucleus
A	1900745	biological_process	positive regulation of p38MAPK cascade
A	1904651	biological_process	positive regulation of fat cell apoptotic process
A	1990051	biological_process	activation of protein kinase C activity
A	1990460	molecular_function	leptin receptor binding
A	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
A	2000486	biological_process	negative regulation of glutamine transport
A	2000491	biological_process	positive regulation of hepatic stellate cell activation