8K0G

Cryo-EM structure of human 26S RP (Ed state) bound to K11/K48-branched ubiquitin (Ub) chain composed of four Ub.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0001649	biological_process	osteoblast differentiation
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0008540	cellular_component	proteasome regulatory particle, base subcomplex
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0022624	cellular_component	proteasome accessory complex
A	0034774	cellular_component	secretory granule lumen
A	0036402	molecular_function	proteasome-activating activity
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	1901800	biological_process	positive regulation of proteasomal protein catabolic process
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000166	molecular_function	nucleotide binding
B	0000502	cellular_component	proteasome complex
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005838	cellular_component	proteasome regulatory particle
B	0008540	cellular_component	proteasome regulatory particle, base subcomplex
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0022624	cellular_component	proteasome accessory complex
B	0036402	molecular_function	proteasome-activating activity
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	1901800	biological_process	positive regulation of proteasomal protein catabolic process
C	0000166	molecular_function	nucleotide binding
C	0000502	cellular_component	proteasome complex
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005838	cellular_component	proteasome regulatory particle
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0008134	molecular_function	transcription factor binding
C	0008540	cellular_component	proteasome regulatory particle, base subcomplex
C	0016020	cellular_component	membrane
C	0016234	cellular_component	inclusion body
C	0016887	molecular_function	ATP hydrolysis activity
C	0017025	molecular_function	TBP-class protein binding
C	0022624	cellular_component	proteasome accessory complex
C	0031410	cellular_component	cytoplasmic vesicle
C	0031531	molecular_function	thyrotropin-releasing hormone receptor binding
C	0031595	cellular_component	nuclear proteasome complex
C	0031597	cellular_component	cytosolic proteasome complex
C	0036402	molecular_function	proteasome-activating activity
C	0043069	biological_process	negative regulation of programmed cell death
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
C	0090261	biological_process	positive regulation of inclusion body assembly
C	0140296	molecular_function	general transcription initiation factor binding
C	0140297	molecular_function	DNA-binding transcription factor binding
C	1901800	biological_process	positive regulation of proteasomal protein catabolic process
D	0000166	molecular_function	nucleotide binding
D	0000502	cellular_component	proteasome complex
D	0001824	biological_process	blastocyst development
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006508	biological_process	proteolysis
D	0008540	cellular_component	proteasome regulatory particle, base subcomplex
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0022624	cellular_component	proteasome accessory complex
D	0036064	cellular_component	ciliary basal body
D	0036402	molecular_function	proteasome-activating activity
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	1901800	biological_process	positive regulation of proteasomal protein catabolic process
E	0000166	molecular_function	nucleotide binding
E	0000502	cellular_component	proteasome complex
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0008540	cellular_component	proteasome regulatory particle, base subcomplex
E	0016020	cellular_component	membrane
E	0016234	cellular_component	inclusion body
E	0016887	molecular_function	ATP hydrolysis activity
E	0022624	cellular_component	proteasome accessory complex
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031597	cellular_component	cytosolic proteasome complex
E	0036402	molecular_function	proteasome-activating activity
E	0036503	biological_process	ERAD pathway
E	0042802	molecular_function	identical protein binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
E	0070062	cellular_component	extracellular exosome
E	0090261	biological_process	positive regulation of inclusion body assembly
E	1901800	biological_process	positive regulation of proteasomal protein catabolic process
F	0000166	molecular_function	nucleotide binding
F	0000502	cellular_component	proteasome complex
F	0000932	cellular_component	P-body
F	0001824	biological_process	blastocyst development
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0008540	cellular_component	proteasome regulatory particle, base subcomplex
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0022624	cellular_component	proteasome accessory complex
F	0034774	cellular_component	secretory granule lumen
F	0036402	molecular_function	proteasome-activating activity
F	0042802	molecular_function	identical protein binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043921	biological_process	modulation by host of viral transcription
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	1901800	biological_process	positive regulation of proteasomal protein catabolic process
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0000502	cellular_component	proteasome complex
G	0000932	cellular_component	P-body
G	0003723	molecular_function	RNA binding
G	0004175	molecular_function	endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0005840	cellular_component	ribosome
G	0005929	cellular_component	cilium
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0016363	cellular_component	nuclear matrix
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030016	cellular_component	myofibril
G	0030017	cellular_component	sarcomere
G	0035639	molecular_function	purine ribonucleoside triphosphate binding
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0050727	biological_process	regulation of inflammatory response
G	0051059	molecular_function	NF-kappaB binding
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0070062	cellular_component	extracellular exosome
H	0000502	cellular_component	proteasome complex
H	0000932	cellular_component	P-body
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005839	cellular_component	proteasome core complex
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0009615	biological_process	response to virus
H	0019773	cellular_component	proteasome core complex, alpha-subunit complex
H	0034774	cellular_component	secretory granule lumen
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0051603	biological_process	proteolysis involved in protein catabolic process
H	0070062	cellular_component	extracellular exosome
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0000502	cellular_component	proteasome complex
I	0000932	cellular_component	P-body
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005839	cellular_component	proteasome core complex
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0019773	cellular_component	proteasome core complex, alpha-subunit complex
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0051603	biological_process	proteolysis involved in protein catabolic process
I	0070062	cellular_component	extracellular exosome
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005839	cellular_component	proteasome core complex
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0019773	cellular_component	proteasome core complex, alpha-subunit complex
J	0042802	molecular_function	identical protein binding
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0051603	biological_process	proteolysis involved in protein catabolic process
J	0070062	cellular_component	extracellular exosome
K	0000502	cellular_component	proteasome complex
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005839	cellular_component	proteasome core complex
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0019773	cellular_component	proteasome core complex, alpha-subunit complex
K	0034774	cellular_component	secretory granule lumen
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0051603	biological_process	proteolysis involved in protein catabolic process
K	0070062	cellular_component	extracellular exosome
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0000502	cellular_component	proteasome complex
L	0001530	molecular_function	lipopolysaccharide binding
L	0002376	biological_process	immune system process
L	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0005839	cellular_component	proteasome core complex
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0019773	cellular_component	proteasome core complex, alpha-subunit complex
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0051603	biological_process	proteolysis involved in protein catabolic process
L	0070062	cellular_component	extracellular exosome
M	0000502	cellular_component	proteasome complex
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005839	cellular_component	proteasome core complex
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0019773	cellular_component	proteasome core complex, alpha-subunit complex
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0051603	biological_process	proteolysis involved in protein catabolic process
M	0070062	cellular_component	extracellular exosome
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005829	cellular_component	cytosol
U	0005838	cellular_component	proteasome regulatory particle
U	0008540	cellular_component	proteasome regulatory particle, base subcomplex
U	0016020	cellular_component	membrane
U	0022624	cellular_component	proteasome accessory complex
U	0030234	molecular_function	enzyme regulator activity
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0034515	cellular_component	proteasome storage granule
U	0035578	cellular_component	azurophil granule lumen
U	0042176	biological_process	regulation of protein catabolic process
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0000502	cellular_component	proteasome complex
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005829	cellular_component	cytosol
V	0005838	cellular_component	proteasome regulatory particle
V	0006511	biological_process	ubiquitin-dependent protein catabolic process
V	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
V	0016020	cellular_component	membrane
V	0022624	cellular_component	proteasome accessory complex
V	0030234	molecular_function	enzyme regulator activity
V	0034774	cellular_component	secretory granule lumen
V	0042176	biological_process	regulation of protein catabolic process
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0070062	cellular_component	extracellular exosome
V	1904813	cellular_component	ficolin-1-rich granule lumen
W	0000502	cellular_component	proteasome complex
W	0005515	molecular_function	protein binding
W	0005576	cellular_component	extracellular region
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005838	cellular_component	proteasome regulatory particle
W	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
W	0016020	cellular_component	membrane
W	0022624	cellular_component	proteasome accessory complex
W	0034774	cellular_component	secretory granule lumen
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0070062	cellular_component	extracellular exosome
W	1904813	cellular_component	ficolin-1-rich granule lumen
X	0000502	cellular_component	proteasome complex
X	0005198	molecular_function	structural molecule activity
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005838	cellular_component	proteasome regulatory particle
X	0006511	biological_process	ubiquitin-dependent protein catabolic process
X	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
X	0016020	cellular_component	membrane
X	0022624	cellular_component	proteasome accessory complex
X	0032991	cellular_component	protein-containing complex
X	0034774	cellular_component	secretory granule lumen
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0043248	biological_process	proteasome assembly
X	0048863	biological_process	stem cell differentiation
X	1904813	cellular_component	ficolin-1-rich granule lumen
Y	0000502	cellular_component	proteasome complex
Y	0005515	molecular_function	protein binding
Y	0005576	cellular_component	extracellular region
Y	0005654	cellular_component	nucleoplasm
Y	0005829	cellular_component	cytosol
Y	0005838	cellular_component	proteasome regulatory particle
Y	0022624	cellular_component	proteasome accessory complex
Y	0032991	cellular_component	protein-containing complex
Y	0034774	cellular_component	secretory granule lumen
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	1904813	cellular_component	ficolin-1-rich granule lumen
Z	0000502	cellular_component	proteasome complex
Z	0005515	molecular_function	protein binding
Z	0005576	cellular_component	extracellular region
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005829	cellular_component	cytosol
Z	0005838	cellular_component	proteasome regulatory particle
Z	0008233	molecular_function	peptidase activity
Z	0008237	molecular_function	metallopeptidase activity
Z	0016020	cellular_component	membrane
Z	0034774	cellular_component	secretory granule lumen
Z	0042803	molecular_function	protein homodimerization activity
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0070062	cellular_component	extracellular exosome
Z	0140492	molecular_function	metal-dependent deubiquitinase activity
Z	1904813	cellular_component	ficolin-1-rich granule lumen
a	0000502	cellular_component	proteasome complex
a	0005198	molecular_function	structural molecule activity
a	0005515	molecular_function	protein binding
a	0005576	cellular_component	extracellular region
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005829	cellular_component	cytosol
a	0005838	cellular_component	proteasome regulatory particle
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0007127	biological_process	meiosis I
a	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
a	0016020	cellular_component	membrane
a	0022624	cellular_component	proteasome accessory complex
a	0034774	cellular_component	secretory granule lumen
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	1904813	cellular_component	ficolin-1-rich granule lumen
b	0000502	cellular_component	proteasome complex
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005829	cellular_component	cytosol
b	0008540	cellular_component	proteasome regulatory particle, base subcomplex
b	0022624	cellular_component	proteasome accessory complex
b	0031593	molecular_function	polyubiquitin modification-dependent protein binding
b	0042802	molecular_function	identical protein binding
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0060090	molecular_function	molecular adaptor activity
c	0000502	cellular_component	proteasome complex
c	0000724	biological_process	double-strand break repair via homologous recombination
c	0005515	molecular_function	protein binding
c	0005576	cellular_component	extracellular region
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005829	cellular_component	cytosol
c	0006281	biological_process	DNA repair
c	0006303	biological_process	double-strand break repair via nonhomologous end joining
c	0006508	biological_process	proteolysis
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0006974	biological_process	DNA damage response
c	0008233	molecular_function	peptidase activity
c	0008237	molecular_function	metallopeptidase activity
c	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
c	0016579	biological_process	protein deubiquitination
c	0016787	molecular_function	hydrolase activity
c	0022624	cellular_component	proteasome accessory complex
c	0031597	cellular_component	cytosolic proteasome complex
c	0034774	cellular_component	secretory granule lumen
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0045471	biological_process	response to ethanol
c	0046872	molecular_function	metal ion binding
c	0061133	molecular_function	endopeptidase activator activity
c	0061136	biological_process	regulation of proteasomal protein catabolic process
c	0061578	molecular_function	K63-linked deubiquitinase activity
c	0070536	biological_process	protein K63-linked deubiquitination
c	0070628	molecular_function	proteasome binding
c	0140492	molecular_function	metal-dependent deubiquitinase activity
c	1904813	cellular_component	ficolin-1-rich granule lumen
d	0000502	cellular_component	proteasome complex
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005829	cellular_component	cytosol
d	0005838	cellular_component	proteasome regulatory particle
d	0006508	biological_process	proteolysis
d	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
d	0022624	cellular_component	proteasome accessory complex
d	0032991	cellular_component	protein-containing complex
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0000502	cellular_component	proteasome complex
e	0000724	biological_process	double-strand break repair via homologous recombination
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005829	cellular_component	cytosol
e	0006406	biological_process	mRNA export from nucleus
e	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
e	0032039	cellular_component	integrator complex
e	0032991	cellular_component	protein-containing complex
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0043248	biological_process	proteasome assembly
f	0000502	cellular_component	proteasome complex
f	0005515	molecular_function	protein binding
f	0005576	cellular_component	extracellular region
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005829	cellular_component	cytosol
f	0005838	cellular_component	proteasome regulatory particle
f	0008540	cellular_component	proteasome regulatory particle, base subcomplex
f	0016020	cellular_component	membrane
f	0022624	cellular_component	proteasome accessory complex
f	0030234	molecular_function	enzyme regulator activity
f	0034515	cellular_component	proteasome storage granule
f	0034774	cellular_component	secretory granule lumen
f	0042176	biological_process	regulation of protein catabolic process
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0070062	cellular_component	extracellular exosome
f	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. AAGFSSSGPAATSGAV

Chain	Residue	Details
d	ALA-21-VAL-6

---

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
u	LYS27-ASP52

---

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. FdrhiTiFSPeGRlyQVEYAfkA

Chain	Residue	Details
G	PHE9-ALA31
J	TYR3-ALA25
H	TYR6-ALA28
M	TYR7-ALA29
I	TYR5-ALA27
L	TYR6-ALA28
K	TYR8-ALA30

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VkVImATNradtLDpALl.R

Chain	Residue	Details
D	VAL305-ARG323
F	VAL326-ARG344
A	ILE315-ARG333
E	VAL273-ARG291
C	ILE289-ARG307
B	VAL325-ARG343

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIlAndGVLLAAErrnihklldevffse.KiyklnedmacsvaGitSD

Chain	Residue	Details
I	LEU35-ASP82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	23
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	135
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	88
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15144186","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"17370265","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	15
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	220
Details	Region: {"description":"May mediate interaction with PRPF9","evidences":[{"source":"UniProtKB","id":"P62196","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QUM9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P49722","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P17220","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"PubMed","id":"16678104","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	5
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	1029
Details	Domain: {"description":"PCI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01185","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"12665801","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	66
Details	Repeat: {"description":"PC 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	69
Details	Repeat: {"description":"PC 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	68
Details	Repeat: {"description":"PC 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	68
Details	Repeat: {"description":"PC 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	62
Details	Repeat: {"description":"PC 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	66
Details	Repeat: {"description":"PC 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	47
Details	Repeat: {"description":"PC 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	11
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"Q8VDM4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"17924679","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDM4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"9725902","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	34
Details	Repeat: {"description":"PC 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	40
Details	Repeat: {"description":"PC 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	32
Details	Repeat: {"description":"PC 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3TXS7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	270
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	183
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	13
Details	Motif: {"description":"JAMM motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17693683","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	300
Details	Domain: {"description":"Ubiquitin-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---