8K0B
Cryo-EM structure of TMEM63C
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003094 | biological_process | glomerular filtration |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006812 | biological_process | monoatomic cation transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 1990760 | molecular_function | osmolarity-sensing monoatomic cation channel activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=TM0","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 286 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 60 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 32 |
| Details | Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"37945568","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8K0B","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
