8JZO

CryoEM structure of the NADP-dependent malic enzyme MaeB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004470	molecular_function	malic enzyme activity
A	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
A	0005829	cellular_component	cytosol
A	0006108	biological_process	malate metabolic process
A	0008948	molecular_function	oxaloacetate decarboxylase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0016746	molecular_function	acyltransferase activity
A	0030145	molecular_function	manganese ion binding
A	0042802	molecular_function	identical protein binding
A	0043883	molecular_function	malolactic enzyme activity
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
B	0003824	molecular_function	catalytic activity
B	0004470	molecular_function	malic enzyme activity
B	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
B	0005829	cellular_component	cytosol
B	0006108	biological_process	malate metabolic process
B	0008948	molecular_function	oxaloacetate decarboxylase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0016746	molecular_function	acyltransferase activity
B	0030145	molecular_function	manganese ion binding
B	0042802	molecular_function	identical protein binding
B	0043883	molecular_function	malolactic enzyme activity
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
C	0003824	molecular_function	catalytic activity
C	0004470	molecular_function	malic enzyme activity
C	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
C	0005829	cellular_component	cytosol
C	0006108	biological_process	malate metabolic process
C	0008948	molecular_function	oxaloacetate decarboxylase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0016746	molecular_function	acyltransferase activity
C	0030145	molecular_function	manganese ion binding
C	0042802	molecular_function	identical protein binding
C	0043883	molecular_function	malolactic enzyme activity
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding
D	0003824	molecular_function	catalytic activity
D	0004470	molecular_function	malic enzyme activity
D	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
D	0005829	cellular_component	cytosol
D	0006108	biological_process	malate metabolic process
D	0008948	molecular_function	oxaloacetate decarboxylase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0016746	molecular_function	acyltransferase activity
D	0030145	molecular_function	manganese ion binding
D	0042802	molecular_function	identical protein binding
D	0043883	molecular_function	malolactic enzyme activity
D	0046872	molecular_function	metal ion binding
D	0051287	molecular_function	NAD binding
E	0003824	molecular_function	catalytic activity
E	0004470	molecular_function	malic enzyme activity
E	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
E	0005829	cellular_component	cytosol
E	0006108	biological_process	malate metabolic process
E	0008948	molecular_function	oxaloacetate decarboxylase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0016746	molecular_function	acyltransferase activity
E	0030145	molecular_function	manganese ion binding
E	0042802	molecular_function	identical protein binding
E	0043883	molecular_function	malolactic enzyme activity
E	0046872	molecular_function	metal ion binding
E	0051287	molecular_function	NAD binding
F	0003824	molecular_function	catalytic activity
F	0004470	molecular_function	malic enzyme activity
F	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
F	0005829	cellular_component	cytosol
F	0006108	biological_process	malate metabolic process
F	0008948	molecular_function	oxaloacetate decarboxylase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0016746	molecular_function	acyltransferase activity
F	0030145	molecular_function	manganese ion binding
F	0042802	molecular_function	identical protein binding
F	0043883	molecular_function	malolactic enzyme activity
F	0046872	molecular_function	metal ion binding
F	0051287	molecular_function	NAD binding

Functional Information from PROSITE/UniProt

site_id	PS00331
Number of Residues	17
Details	MALIC_ENZYMES Malic enzymes signature. FhDDqhGTAiIsTAAIL

Chain	Residue	Details
A	PHE159-LEU175

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2562
Details	Region: {"description":"Malic enzyme"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1980
Details	Region: {"description":"Phosphate acetyltransferase; required for oligomerization, inhibition by acetyl-CoA and activation by glutamate, aspartate, and glucose-6-phosphate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P40927","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P40927","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P40927","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---