Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8JXI

rat megalin RAP complex wingB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding
C	0002091	biological_process	negative regulation of receptor internalization
C	0005515	molecular_function	protein binding
C	0005768	cellular_component	endosome
C	0005783	cellular_component	endoplasmic reticulum
C	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
C	0005794	cellular_component	Golgi apparatus
C	0005796	cellular_component	Golgi lumen
C	0005801	cellular_component	cis-Golgi network
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0008150	biological_process	biological_process
C	0008201	molecular_function	heparin binding
C	0009986	cellular_component	cell surface
C	0010916	biological_process	negative regulation of very-low-density lipoprotein particle clearance
C	0012505	cellular_component	endomembrane system
C	0031904	cellular_component	endosome lumen
C	0031982	cellular_component	vesicle
C	0035473	molecular_function	lipase binding
C	0048018	molecular_function	receptor ligand activity
C	0048019	molecular_function	receptor antagonist activity
C	0048237	cellular_component	rough endoplasmic reticulum lumen
C	0048259	biological_process	regulation of receptor-mediated endocytosis
C	0050750	molecular_function	low-density lipoprotein particle receptor binding
C	0070326	molecular_function	very-low-density lipoprotein particle receptor binding
C	0150093	biological_process	amyloid-beta clearance by transcytosis
C	1900222	biological_process	negative regulation of amyloid-beta clearance

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNmrgsFrCaC

Chain	Residue	Details
A	CYS1405-CYS1416
A	CYS3128-CYS3139
A	CYS3169-CYS3180
A	CYS4023-CYS4034

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. HNEL

Chain	Residue	Details
C	HIS357-LEU360

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CkCssGysGEyC

Chain	Residue	Details
A	CYS4401-CYS4412

site_id	PS00615
Number of Residues	27
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CVdideckespq..LCSQKCenvvgsYIC

Chain	Residue	Details
A	CYS3152-CYS3178

site_id	PS01186
Number of Residues	15
Details	EGF_2 EGF-like domain signature 2. ClCeeGYilergqh.C

Chain	Residue	Details
A	CYS370-CYS384
A	CYS688-CYS703
A	CYS1374-CYS1389
A	CYS1726-CYS1741
A	CYS2044-CYS2059
A	CYS3137-CYS3152
A	CYS3178-CYS3193
A	CYS4401-CYS4412

site_id	PS01187
Number of Residues	24
Details	EGF_CA Calcium-binding EGF-like domain signature. DiNECdipgf.........Csqh....CvNmrgsFrC

Chain	Residue	Details
A	ASP1391-CYS1414
A	ASP3154-CYS3178
A	ASP4009-CYS4032

site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIpaswr.CDgtrDCldd.TDEig...C

Chain	Residue	Details
A	CYS40-CYS62
A	CYS1201-CYS1223
A	CYS1244-CYS1267
A	CYS1284-CYS1306
A	CYS1326-CYS1349
A	CYS2713-CYS2737
A	CYS2754-CYS2776
A	CYS2836-CYS2860
A	CYS2878-CYS2901
A	CYS2920-CYS2945
A	CYS3007-CYS3029
A	CYS80-CYS103
A	CYS3046-CYS3070
A	CYS3089-CYS3111
A	CYS3527-CYS3550
A	CYS3608-CYS3632
A	CYS3649-CYS3673
A	CYS3694-CYS3716
A	CYS3734-CYS3756
A	CYS3773-CYS3795
A	CYS3812-CYS3834
A	CYS3856-CYS3880
A	CYS120-CYS142
A	CYS3898-CYS3922
A	CYS3942-CYS3964
A	CYS195-CYS217
A	CYS234-CYS256
A	CYS1037-CYS1059
A	CYS1079-CYS1101
A	CYS1122-CYS1144
A	CYS1162-CYS1184

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	42
Details	Repeat: {"description":"LDL-receptor class B 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	42
Details	Repeat: {"description":"LDL-receptor class B 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	46
Details	Repeat: {"description":"LDL-receptor class B 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	44
Details	Repeat: {"description":"LDL-receptor class B 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	41
Details	Repeat: {"description":"LDL-receptor class B 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	43
Details	Repeat: {"description":"LDL-receptor class B 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	36
Details	Domain: {"description":"LDL-receptor class A 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	43
Details	Domain: {"description":"LDL-receptor class A 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	35
Details	Domain: {"description":"EGF-like 1; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	42
Details	Repeat: {"description":"LDL-receptor class B 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	43
Details	Repeat: {"description":"LDL-receptor class B 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	36
Details	Domain: {"description":"LDL-receptor class A 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	37
Details	Domain: {"description":"LDL-receptor class A 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	36
Details	Domain: {"description":"LDL-receptor class A 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	36
Details	Domain: {"description":"LDL-receptor class A 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	37
Details	Domain: {"description":"LDL-receptor class A 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	36
Details	Domain: {"description":"LDL-receptor class A 14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P98164","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17245526","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	36
Details	Domain: {"description":"LDL-receptor class A 17","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	39
Details	Domain: {"description":"LDL-receptor class A 18","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	39
Details	Domain: {"description":"LDL-receptor class A 19","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)