8JXH
rat megalin RAP complex wingA
Functional Information from GO Data
Chain | GOid | namespace | contents |
D | 0002091 | biological_process | negative regulation of receptor internalization |
D | 0005515 | molecular_function | protein binding |
D | 0005768 | cellular_component | endosome |
D | 0005783 | cellular_component | endoplasmic reticulum |
D | 0005793 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment |
D | 0005794 | cellular_component | Golgi apparatus |
D | 0005796 | cellular_component | Golgi lumen |
D | 0005801 | cellular_component | cis-Golgi network |
D | 0005886 | cellular_component | plasma membrane |
D | 0007165 | biological_process | signal transduction |
D | 0008150 | biological_process | biological_process |
D | 0008201 | molecular_function | heparin binding |
D | 0009986 | cellular_component | cell surface |
D | 0010916 | biological_process | negative regulation of very-low-density lipoprotein particle clearance |
D | 0012505 | cellular_component | endomembrane system |
D | 0031904 | cellular_component | endosome lumen |
D | 0031982 | cellular_component | vesicle |
D | 0035473 | molecular_function | lipase binding |
D | 0048018 | molecular_function | receptor ligand activity |
D | 0048019 | molecular_function | receptor antagonist activity |
D | 0048237 | cellular_component | rough endoplasmic reticulum lumen |
D | 0048259 | biological_process | regulation of receptor-mediated endocytosis |
D | 0050750 | molecular_function | low-density lipoprotein particle receptor binding |
D | 0070326 | molecular_function | very-low-density lipoprotein particle receptor binding |
D | 0150093 | biological_process | amyloid-beta clearance by transcytosis |
D | 1900222 | biological_process | negative regulation of amyloid-beta clearance |
Functional Information from PROSITE/UniProt
site_id | PS00010 |
Number of Residues | 12 |
Details | ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNmrgsFrCaC |
Chain | Residue | Details |
A | CYS1405-CYS1416 | |
A | CYS3128-CYS3139 | |
A | CYS3169-CYS3180 | |
A | CYS4023-CYS4034 |
site_id | PS00014 |
Number of Residues | 4 |
Details | ER_TARGET Endoplasmic reticulum targeting sequence. HNEL |
Chain | Residue | Details |
D | HIS357-LEU360 |
site_id | PS00022 |
Number of Residues | 12 |
Details | EGF_1 EGF-like domain signature 1. CkCssGysGEyC |
Chain | Residue | Details |
A | CYS4401-CYS4412 |
site_id | PS00615 |
Number of Residues | 27 |
Details | C_TYPE_LECTIN_1 C-type lectin domain signature. CVdideckespq..LCSQKCenvvgsYIC |
Chain | Residue | Details |
A | CYS3152-CYS3178 |
site_id | PS01186 |
Number of Residues | 15 |
Details | EGF_2 EGF-like domain signature 2. ClCeeGYilergqh.C |
Chain | Residue | Details |
A | CYS370-CYS384 | |
A | CYS688-CYS703 | |
A | CYS1374-CYS1389 | |
A | CYS1726-CYS1741 | |
A | CYS2044-CYS2059 | |
A | CYS3137-CYS3152 | |
A | CYS3178-CYS3193 | |
A | CYS4401-CYS4412 |
site_id | PS01187 |
Number of Residues | 24 |
Details | EGF_CA Calcium-binding EGF-like domain signature. DiNECdipgf.........Csqh....CvNmrgsFrC |
Chain | Residue | Details |
A | ASP1391-CYS1414 | |
A | ASP3154-CYS3178 | |
A | ASP4009-CYS4032 |
site_id | PS01209 |
Number of Residues | 23 |
Details | LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIpaswr.CDgtrDCldd.TDEig...C |
Chain | Residue | Details |
A | CYS40-CYS62 | |
A | CYS1201-CYS1223 | |
A | CYS1244-CYS1267 | |
A | CYS1284-CYS1306 | |
A | CYS1326-CYS1349 | |
A | CYS2713-CYS2737 | |
A | CYS2754-CYS2776 | |
A | CYS2836-CYS2860 | |
A | CYS2878-CYS2901 | |
A | CYS2920-CYS2945 | |
A | CYS3007-CYS3029 | |
A | CYS80-CYS103 | |
A | CYS3046-CYS3070 | |
A | CYS3089-CYS3111 | |
A | CYS3527-CYS3550 | |
A | CYS3608-CYS3632 | |
A | CYS3649-CYS3673 | |
A | CYS3694-CYS3716 | |
A | CYS3734-CYS3756 | |
A | CYS3773-CYS3795 | |
A | CYS3812-CYS3834 | |
A | CYS3856-CYS3880 | |
A | CYS120-CYS142 | |
A | CYS3898-CYS3922 | |
A | CYS3942-CYS3964 | |
A | CYS195-CYS217 | |
A | CYS234-CYS256 | |
A | CYS1037-CYS1059 | |
A | CYS1079-CYS1101 | |
A | CYS1122-CYS1144 | |
A | CYS1162-CYS1184 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8798 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
A | GLN26-THR4425 | |
B | GLN26-THR4425 |
site_id | SWS_FT_FI2 |
Number of Residues | 40 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
A | MET4426-LEU4446 | |
B | MET4426-LEU4446 |
site_id | SWS_FT_FI3 |
Number of Residues | 426 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | PHE4447-VAL4660 | |
B | PHE4447-VAL4660 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P98164 |
Chain | Residue | Details |
A | TRP1127 | |
B | ASP1134 | |
B | ASP1140 | |
B | GLU1141 | |
A | ASP1130 | |
A | ASP1132 | |
A | ASP1134 | |
A | ASP1140 | |
A | GLU1141 | |
B | TRP1127 | |
B | ASP1130 | |
B | ASP1132 |
site_id | SWS_FT_FI5 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17245526 |
Chain | Residue | Details |
A | TYR1206 | |
B | ASP1213 | |
B | ASP1219 | |
B | GLU1220 | |
A | ASP1209 | |
A | VAL1211 | |
A | ASP1213 | |
A | ASP1219 | |
A | GLU1220 | |
B | TYR1206 | |
B | ASP1209 | |
B | VAL1211 |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
Chain | Residue | Details |
A | SER4464 | |
A | SER4577 | |
A | SER4624 | |
A | SER4658 | |
B | SER4464 | |
B | SER4577 | |
B | SER4624 | |
B | SER4658 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:A2ARV4 |
Chain | Residue | Details |
A | SER4467 | |
B | SER4467 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:A2ARV4 |
Chain | Residue | Details |
A | THR4637 | |
B | THR4637 |
site_id | SWS_FT_FI9 |
Number of Residues | 84 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN159 | |
A | ASN1187 | |
A | ASN1328 | |
A | ASN1341 | |
A | ASN1384 | |
A | ASN1451 | |
A | ASN1497 | |
A | ASN1551 | |
A | ASN1676 | |
A | ASN1733 | |
A | ASN1811 | |
A | ASN178 | |
A | ASN2134 | |
A | ASN2178 | |
A | ASN2225 | |
A | ASN2396 | |
A | ASN2488 | |
A | ASN2548 | |
A | ASN2782 | |
A | ASN2810 | |
A | ASN2949 | |
A | ASN2989 | |
A | ASN259 | |
A | ASN3127 | |
A | ASN3213 | |
A | ASN3259 | |
A | ASN3317 | |
A | ASN3357 | |
A | ASN3448 | |
A | ASN3566 | |
A | ASN3682 | |
A | ASN3840 | |
A | ASN3969 | |
A | ASN299 | |
A | ASN3980 | |
A | ASN4070 | |
A | ASN4329 | |
B | ASN159 | |
B | ASN178 | |
B | ASN259 | |
B | ASN299 | |
B | ASN340 | |
B | ASN462 | |
B | ASN657 | |
A | ASN340 | |
B | ASN865 | |
B | ASN1063 | |
B | ASN1187 | |
B | ASN1328 | |
B | ASN1341 | |
B | ASN1384 | |
B | ASN1451 | |
B | ASN1497 | |
B | ASN1551 | |
B | ASN1676 | |
A | ASN462 | |
B | ASN1733 | |
B | ASN1811 | |
B | ASN2134 | |
B | ASN2178 | |
B | ASN2225 | |
B | ASN2396 | |
B | ASN2488 | |
B | ASN2548 | |
B | ASN2782 | |
B | ASN2810 | |
A | ASN657 | |
B | ASN2949 | |
B | ASN2989 | |
B | ASN3127 | |
B | ASN3213 | |
B | ASN3259 | |
B | ASN3317 | |
B | ASN3357 | |
B | ASN3448 | |
B | ASN3566 | |
B | ASN3682 | |
A | ASN865 | |
B | ASN3840 | |
B | ASN3969 | |
B | ASN3980 | |
B | ASN4070 | |
B | ASN4329 | |
A | ASN1063 |