8JXF

rat megalin RAP complex bodyA

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005509	molecular_function	calcium ion binding
C	0005783	cellular_component	endoplasmic reticulum
C	0008201	molecular_function	heparin binding
C	0048019	molecular_function	receptor antagonist activity
C	0050750	molecular_function	low-density lipoprotein particle receptor binding

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNmrgsFrCaC

Chain	Residue	Details
B	CYS1405-CYS1416
B	CYS3128-CYS3139
B	CYS3169-CYS3180
B	CYS4023-CYS4034

---

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. HNEL

Chain	Residue	Details
C	HIS357-LEU360

---

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CkCssGysGEyC

Chain	Residue	Details
B	CYS4401-CYS4412

---

site_id	PS00615
Number of Residues	27
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CVdideckespq..LCSQKCenvvgsYIC

Chain	Residue	Details
B	CYS3152-CYS3178

---

site_id	PS01186
Number of Residues	15
Details	EGF_2 EGF-like domain signature 2. ClCeeGYilergqh.C

Chain	Residue	Details
B	CYS370-CYS384
B	CYS688-CYS703
B	CYS1374-CYS1389
B	CYS1726-CYS1741
B	CYS2044-CYS2059
B	CYS3137-CYS3152
B	CYS3178-CYS3193
B	CYS4401-CYS4412

---

site_id	PS01187
Number of Residues	24
Details	EGF_CA Calcium-binding EGF-like domain signature. DiNECdipgf.........Csqh....CvNmrgsFrC

Chain	Residue	Details
B	ASP1391-CYS1414
B	ASP3154-CYS3178
B	ASP4009-CYS4032

---

site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIpaswr.CDgtrDCldd.TDEig...C

Chain	Residue	Details
B	CYS40-CYS62
B	CYS1201-CYS1223
B	CYS1244-CYS1267
B	CYS1284-CYS1306
B	CYS1326-CYS1349
B	CYS2713-CYS2737
B	CYS2754-CYS2776
B	CYS2836-CYS2860
B	CYS2878-CYS2901
B	CYS2920-CYS2945
B	CYS3007-CYS3029
B	CYS80-CYS103
B	CYS3046-CYS3070
B	CYS3089-CYS3111
B	CYS3527-CYS3550
B	CYS3608-CYS3632
B	CYS3649-CYS3673
B	CYS3694-CYS3716
B	CYS3734-CYS3756
B	CYS3773-CYS3795
B	CYS3812-CYS3834
B	CYS3856-CYS3880
B	CYS120-CYS142
B	CYS3898-CYS3922
B	CYS3942-CYS3964
B	CYS195-CYS217
B	CYS234-CYS256
B	CYS1037-CYS1059
B	CYS1079-CYS1101
B	CYS1122-CYS1144
B	CYS1162-CYS1184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Repeat: {"description":"LDL-receptor class B 28","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	43
Details	Repeat: {"description":"LDL-receptor class B 30","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	Repeat: {"description":"LDL-receptor class B 31","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 20","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	39
Details	Domain: {"description":"LDL-receptor class A 21","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	42
Details	Domain: {"description":"LDL-receptor class A 22","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	36
Details	Domain: {"description":"LDL-receptor class A 23","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 24","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	36
Details	Domain: {"description":"LDL-receptor class A 25","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	41
Details	Domain: {"description":"EGF-like 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	40
Details	Domain: {"description":"EGF-like 5; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	42
Details	Repeat: {"description":"LDL-receptor class B 29","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	40
Details	Repeat: {"description":"LDL-receptor class B 32","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 26","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 27","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 28","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 29","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 30","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	37
Details	Domain: {"description":"LDL-receptor class A 31","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	36
Details	Domain: {"description":"LDL-receptor class A 32","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	36
Details	Domain: {"description":"LDL-receptor class A 33","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 34","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	39
Details	Domain: {"description":"LDL-receptor class A 35","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	11
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---