8JWU

PHD Finger Protein 7 (PHF7) fused to UBE2D2 via a (GSGG)3 linker

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000209	biological_process	protein polyubiquitination
A	0003674	molecular_function	molecular_function
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0008150	biological_process	biological_process
A	0008270	molecular_function	zinc ion binding
A	0016567	biological_process	protein ubiquitination
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0032991	cellular_component	protein-containing complex
A	0036211	biological_process	protein modification process
A	0046872	molecular_function	metal ion binding
A	0051865	biological_process	protein autoubiquitination
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0061631	molecular_function	ubiquitin conjugating enzyme activity
A	0070062	cellular_component	extracellular exosome
A	0070936	biological_process	protein K48-linked ubiquitination
A	0090291	biological_process	negative regulation of osteoclast proliferation
B	0000166	molecular_function	nucleotide binding
B	0000209	biological_process	protein polyubiquitination
B	0003674	molecular_function	molecular_function
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0008150	biological_process	biological_process
B	0008270	molecular_function	zinc ion binding
B	0016567	biological_process	protein ubiquitination
B	0016607	cellular_component	nuclear speck
B	0016740	molecular_function	transferase activity
B	0032991	cellular_component	protein-containing complex
B	0036211	biological_process	protein modification process
B	0046872	molecular_function	metal ion binding
B	0051865	biological_process	protein autoubiquitination
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0061631	molecular_function	ubiquitin conjugating enzyme activity
B	0070062	cellular_component	extracellular exosome
B	0070936	biological_process	protein K48-linked ubiquitination
B	0090291	biological_process	negative regulation of osteoclast proliferation
C	0000166	molecular_function	nucleotide binding
C	0000209	biological_process	protein polyubiquitination
C	0003674	molecular_function	molecular_function
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0008150	biological_process	biological_process
C	0008270	molecular_function	zinc ion binding
C	0016567	biological_process	protein ubiquitination
C	0016607	cellular_component	nuclear speck
C	0016740	molecular_function	transferase activity
C	0032991	cellular_component	protein-containing complex
C	0036211	biological_process	protein modification process
C	0046872	molecular_function	metal ion binding
C	0051865	biological_process	protein autoubiquitination
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0061631	molecular_function	ubiquitin conjugating enzyme activity
C	0070062	cellular_component	extracellular exosome
C	0070936	biological_process	protein K48-linked ubiquitination
C	0090291	biological_process	negative regulation of osteoclast proliferation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	438
Details	Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	98
Details	Zinc finger: {"description":"PHD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01146","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	144
Details	Zinc finger: {"description":"RING-type; degenerate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PDB","id":"8JWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JWS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JWU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PDB","id":"8JWJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JWU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Site: {"description":"Cleavage","evidences":[{"source":"PubMed","id":"37993255","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	114
Details	Region: {"description":"Required for association with and ubiquitination of H3","evidences":[{"source":"PubMed","id":"37993255","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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