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8JVH

Cryo-EM structure of Plasmodium falciparum multidrug resistance protein 1 in the apo state with H1 helix

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005773cellular_componentvacuole
A0005774cellular_componentvacuolar membrane
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0020020cellular_componentfood vacuole
A0042626molecular_functionATPase-coupled transmembrane transporter activity
A0046872molecular_functionmetal ion binding
A0055085biological_processtransmembrane transport
A0140359molecular_functionABC-type transporter activity
Functional Information from PROSITE/UniProt
site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRISIARAI
ChainResidueDetails
ALEU563-ILE577
ALEU1312-LEU1326

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1105
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AMET1-SER60
ASER112-THR168
AASN213-GLU275
APRO338-ASP788
ATYR851-ASN907
AARG950-GLY1032
ALYS1079-LYS1419

site_idSWS_FT_FI2
Number of Residues240
DetailsTRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441
ChainResidueDetails
APHE61-ILE81
ACYS929-VAL949
APHE1033-ILE1053
AILE1058-GLY1078
AILE91-ILE111
ALYS169-ILE189
AALA192-CYS212
AALA276-TYR296
AALA317-LEU337
AVAL789-LEU809
ATYR830-TYR850
AILE908-PHE928

site_idSWS_FT_FI3
Number of Residues50
DetailsTOPO_DOM: Vacuolar => ECO:0000305
ChainResidueDetails
ALEU82-ASP90
ALYS190-ASN191
AGLY297-GLY316
ATYR810-LYS829
ALYS1054-THR1057

site_idSWS_FT_FI4
Number of Residues27
DetailsBINDING: BINDING => ECO:0000269|PubMed:37527341, ECO:0007744|PDB:8JWI
ChainResidueDetails
ATYR387
AGLN462
ALYS562
ASER564
AGLY566
AGLN567
ATYR1135
AARG1138
ATHR1163
AGLY1164
AGLY1166
ATHR389
ALYS1167
ASER1168
ATHR1169
AGLN1256
ALEU1312
ASER1313
AGLY1315
AGLN1316
AARG390
ASER415
ACYS417
AGLY418
ALYS419
ASER420
ATHR421

site_idSWS_FT_FI5
Number of Residues1
DetailsSITE: Important for mefloquine and halofantrine binding => ECO:0000269|PubMed:37527341
ChainResidueDetails
APHE331

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PDB entries from 2025-06-11

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