8JSW

Human VMAT2 complex with serotonin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0055085	biological_process	transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	247
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	LEU21-VAL41
A	GLY390-VAL410
A	VAL415-ILE435
A	GLY441-LEU462
A	GLN130-GLY150
A	ILE160-SER180
A	SER190-VAL210
A	VAL220-LEU242
A	THR249-GLN271
A	PRO292-LEU311
A	GLN329-ALA352
A	TRP358-ALA378

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site_id	SWS_FT_FI2
Number of Residues	130
Details	TOPO_DOM: Lumenal, vesicle => ECO:0000255

Chain	Residue	Details
A	PRO42-VAL129
A	SER181-ARG189
A	TYR243-LYS248
A	GLU312-TRP328
A	LYS379-PHE389
A	GLY436-GLY440

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site_id	SWS_FT_FI3
Number of Residues	42
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LEU151-PRO159
A	TYR211-ASN219
A	PRO272-ASP291
A	HIS353-ARG357
A	ASP411-HIS414

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN84
A	ASN91

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