8JPR
Cryo-EM structure of Y553C human ClC-6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005247 | molecular_function | voltage-gated chloride channel activity |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0007165 | biological_process | signal transduction |
| A | 0009612 | biological_process | response to mechanical stimulus |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005247 | molecular_function | voltage-gated chloride channel activity |
| B | 0005254 | molecular_function | chloride channel activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006821 | biological_process | chloride transport |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0007165 | biological_process | signal transduction |
| B | 0009612 | biological_process | response to mechanical stimulus |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0015108 | molecular_function | chloride transmembrane transporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0055085 | biological_process | transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 434 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 104 |
| Details | Intramembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Intramembrane: {"description":"Note=Loop between two helices","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 122 |
| Details | Domain: {"description":"CBS 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00703","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Selectivity filter part_3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Site: {"description":"Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Site: {"description":"Mediates proton transfer from the protein to the inner aqueous phase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O35454","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17534424","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
