8JPO
Cryo-EM structure of ATP bound human ClC-6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005247 | molecular_function | voltage-gated chloride channel activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005768 | cellular_component | endosome |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0007165 | biological_process | signal transduction |
| A | 0009612 | biological_process | response to mechanical stimulus |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0005247 | molecular_function | voltage-gated chloride channel activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005768 | cellular_component | endosome |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006821 | biological_process | chloride transport |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0007165 | biological_process | signal transduction |
| B | 0009612 | biological_process | response to mechanical stimulus |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0015108 | molecular_function | chloride transmembrane transporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0055085 | biological_process | transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 752 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250 |
| Chain | Residue | Details |
| A | MET1-LYS80 | |
| A | ASN572-ILE869 | |
| B | MET1-LYS80 | |
| B | ASN572-ILE869 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 434 |
| Details | TRANSMEM: Helical => ECO:0000250 |
| Chain | Residue | Details |
| A | TRP81-VAL113 | |
| A | TYR553-PHE571 | |
| B | TRP81-VAL113 | |
| B | LEU128-ILE150 | |
| B | ARG176-GLY194 | |
| B | GLU200-PHE217 | |
| B | THR277-PHE294 | |
| B | GLY335-ARG364 | |
| B | LYS371-ALA392 | |
| B | PRO462-GLY481 | |
| B | GLY487-ILE511 | |
| A | LEU128-ILE150 | |
| B | TYR553-PHE571 | |
| A | ARG176-GLY194 | |
| A | GLU200-PHE217 | |
| A | THR277-PHE294 | |
| A | GLY335-ARG364 | |
| A | LYS371-ALA392 | |
| A | PRO462-GLY481 | |
| A | GLY487-ILE511 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 104 |
| Details | INTRAMEM: Helical => ECO:0000250 |
| Chain | Residue | Details |
| A | ILE159-LEU166 | |
| B | THR537-THR548 | |
| A | PHE241-ALA253 | |
| A | PRO257-LEU265 | |
| A | GLY519-VAL533 | |
| A | THR537-THR548 | |
| B | ILE159-LEU166 | |
| B | PHE241-ALA253 | |
| B | PRO257-LEU265 | |
| B | GLY519-VAL533 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | INTRAMEM: Note=Loop between two helices => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL534-MET536 | |
| A | ASN549-THR552 | |
| B | VAL534-MET536 | |
| B | ASN549-THR552 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | SER157 | |
| B | THR849 | |
| A | PHE489 | |
| A | TYR576 | |
| A | HIS630 | |
| A | THR849 | |
| B | SER157 | |
| B | PHE489 | |
| B | TYR576 | |
| B | HIS630 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU200 | |
| B | GLU200 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Mediates proton transfer from the protein to the inner aqueous phase => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU267 | |
| B | GLU267 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35454 |
| Chain | Residue | Details |
| A | SER773 | |
| B | SER773 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17534424 |
| Chain | Residue | Details |
| A | ASN410 | |
| A | ASN422 | |
| A | ASN432 | |
| B | ASN410 | |
| B | ASN422 | |
| B | ASN432 |
