8JP8
Cryo-EM structure of the head region of full-length ERGIC-53 with MCFD2 (Substate C)
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DYDGNNLLDglEL |
| Chain | Residue | Details |
| C | ASP81-LEU93 | |
| C | ASP129-PHE141 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| C | ASP81 | |
| C | ASP83 | |
| C | ASN85 | |
| C | GLU92 | |
| C | ASP129 | |
| C | ASN131 | |
| C | ASP133 | |
| C | TYR135 | |
| C | GLU140 | |
| D | ASP81 | |
| D | ASP83 | |
| D | ASN85 | |
| D | GLU92 | |
| D | ASP129 | |
| D | ASN131 | |
| D | ASP133 | |
| D | TYR135 | |
| D | GLU140 | |
| G | ASP81 | |
| G | ASP83 | |
| G | ASN85 | |
| G | GLU92 | |
| G | ASP129 | |
| G | ASN131 | |
| G | ASP133 | |
| G | TYR135 | |
| G | GLU140 | |
| H | ASP81 | |
| H | ASP83 | |
| H | ASN85 | |
| H | GLU92 | |
| H | ASP129 | |
| H | ASN131 | |
| H | ASP133 | |
| H | TYR135 | |
| H | GLU140 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8K5B3 |
| Chain | Residue | Details |
| C | SER106 | |
| D | SER106 | |
| G | SER106 | |
| H | SER106 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG499-PHE510 | |
| B | ARG499-PHE510 | |
| E | ARG499-PHE510 | |
| F | ARG499-PHE510 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00658 |
| Chain | Residue | Details |
| A | SER88 | |
| A | ASP121 | |
| A | HIS178 | |
| A | GLY251 | |
| B | SER88 | |
| B | ASP121 | |
| B | HIS178 | |
| B | GLY251 | |
| E | SER88 | |
| E | ASP121 | |
| E | HIS178 | |
| E | GLY251 | |
| F | SER88 | |
| F | ASP121 | |
| F | HIS178 | |
| F | GLY251 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP152 | |
| A | PHE154 | |
| A | ASN156 | |
| A | ASP181 | |
| B | ASP152 | |
| B | PHE154 | |
| B | ASN156 | |
| B | ASP181 | |
| E | ASP152 | |
| E | PHE154 | |
| E | ASN156 | |
| E | ASP181 | |
| F | ASP152 | |
| F | PHE154 | |
| F | ASN156 | |
| F | ASP181 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | SITE: Required for ER export |
| Chain | Residue | Details |
| A | GLN501 | |
| B | GLN501 | |
| E | GLN501 | |
| F | GLN501 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER425 | |
| B | SER425 | |
| E | SER425 | |
| F | SER425 |
