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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8JOL

cryo-EM structure of the CED-4/CED-3 holoenzyme

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006915biological_processapoptotic process
A0008303cellular_componentcaspase complex
A0008361biological_processregulation of cell size
A0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
A0009792biological_processembryo development ending in birth or egg hatching
A0010954biological_processpositive regulation of protein processing
A0016020cellular_componentmembrane
A0016505molecular_functionpeptidase activator activity involved in apoptotic process
A0030042biological_processactin filament depolymerization
A0030155biological_processregulation of cell adhesion
A0031647biological_processregulation of protein stability
A0032991cellular_componentprotein-containing complex
A0040034biological_processregulation of development, heterochronic
A0042802molecular_functionidentical protein binding
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043531molecular_functionADP binding
A0046716biological_processmuscle cell cellular homeostasis
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048598biological_processembryonic morphogenesis
A0050829biological_processdefense response to Gram-negative bacterium
A0051432molecular_functionBH1 domain binding
A0051434molecular_functionBH3 domain binding
A0061133molecular_functionendopeptidase activator activity
A0089720molecular_functioncaspase binding
A0140608molecular_functioncysteine-type endopeptidase activator activity
A1900118biological_processnegative regulation of execution phase of apoptosis
A1902742biological_processapoptotic process involved in development
A1904747biological_processpositive regulation of apoptotic process involved in development
A1905808biological_processpositive regulation of synapse pruning
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0008303cellular_componentcaspase complex
B0008361biological_processregulation of cell size
B0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
B0009792biological_processembryo development ending in birth or egg hatching
B0010954biological_processpositive regulation of protein processing
B0016020cellular_componentmembrane
B0016505molecular_functionpeptidase activator activity involved in apoptotic process
B0030042biological_processactin filament depolymerization
B0030155biological_processregulation of cell adhesion
B0031647biological_processregulation of protein stability
B0032991cellular_componentprotein-containing complex
B0040034biological_processregulation of development, heterochronic
B0042802molecular_functionidentical protein binding
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043531molecular_functionADP binding
B0046716biological_processmuscle cell cellular homeostasis
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048598biological_processembryonic morphogenesis
B0050829biological_processdefense response to Gram-negative bacterium
B0051432molecular_functionBH1 domain binding
B0051434molecular_functionBH3 domain binding
B0061133molecular_functionendopeptidase activator activity
B0089720molecular_functioncaspase binding
B0140608molecular_functioncysteine-type endopeptidase activator activity
B1900118biological_processnegative regulation of execution phase of apoptosis
B1902742biological_processapoptotic process involved in development
B1904747biological_processpositive regulation of apoptotic process involved in development
B1905808biological_processpositive regulation of synapse pruning
C0004175molecular_functionendopeptidase activity
C0004197molecular_functioncysteine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0006508biological_processproteolysis
C0006915biological_processapoptotic process
C0008047molecular_functionenzyme activator activity
C0008233molecular_functionpeptidase activity
C0008234molecular_functioncysteine-type peptidase activity
C0008303cellular_componentcaspase complex
C0008656molecular_functioncysteine-type endopeptidase activator activity involved in apoptotic process
C0009792biological_processembryo development ending in birth or egg hatching
C0010954biological_processpositive regulation of protein processing
C0012501biological_processprogrammed cell death
C0016020cellular_componentmembrane
C0016540biological_processprotein autoprocessing
C0016787molecular_functionhydrolase activity
C0030042biological_processactin filament depolymerization
C0030155biological_processregulation of cell adhesion
C0030163biological_processprotein catabolic process
C0031647biological_processregulation of protein stability
C0031965cellular_componentnuclear membrane
C0040012biological_processregulation of locomotion
C0040028biological_processregulation of vulval development
C0040034biological_processregulation of development, heterochronic
C0042659biological_processregulation of cell fate specification
C0042802molecular_functionidentical protein binding
C0042981biological_processregulation of apoptotic process
C0043025cellular_componentneuronal cell body
C0043204cellular_componentperikaryon
C0043525biological_processpositive regulation of neuron apoptotic process
C0045202cellular_componentsynapse
C0046716biological_processmuscle cell cellular homeostasis
C0048471cellular_componentperinuclear region of cytoplasm
C0050807biological_processregulation of synapse organization
C0050829biological_processdefense response to Gram-negative bacterium
C0097194biological_processexecution phase of apoptosis
C0098793cellular_componentpresynapse
C0140608molecular_functioncysteine-type endopeptidase activator activity
C1900118biological_processnegative regulation of execution phase of apoptosis
C1902742biological_processapoptotic process involved in development
C1904747biological_processpositive regulation of apoptotic process involved in development
C1905803biological_processnegative regulation of cellular response to manganese ion
C1905808biological_processpositive regulation of synapse pruning
C1905845biological_processpositive regulation of cellular response to gamma radiation
Functional Information from PROSITE/UniProt
site_idPS01121
Number of Residues13
DetailsCASPASE_HIS Caspase family histidine active site. Hgd..SaiLvILSHG
ChainResidueDetails
CHIS304-GLY316
site_idPS01122
Number of Residues12
DetailsCASPASE_CYS Caspase family cysteine active site. KPKIVFVQACRG
ChainResidueDetails
CLYS349-GLY360
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues180
DetailsDomain: {"description":"CARD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00046","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Z","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JNS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16208361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24065769","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37402593","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JOL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20434985","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LQR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

250835

PDB entries from 2026-03-18

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