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8JMM

Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution.

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
A0019031cellular_componentviral envelope
A0019062biological_processvirion attachment to host cell
A0019064biological_processfusion of virus membrane with host plasma membrane
A0019081biological_processviral translation
A0020002cellular_componenthost cell plasma membrane
A0039587biological_processsuppression by virus of host tetherin activity
A0039654biological_processfusion of virus membrane with host endosome membrane
A0039660molecular_functionstructural constituent of virion
A0042802molecular_functionidentical protein binding
A0043655cellular_componenthost extracellular space
A0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
A0044228cellular_componenthost cell surface
A0046598biological_processpositive regulation of viral entry into host cell
A0046718biological_processsymbiont entry into host cell
A0046789molecular_functionhost cell surface receptor binding
A0046813biological_processreceptor-mediated virion attachment to host cell
A0048018molecular_functionreceptor ligand activity
A0052170biological_processsymbiont-mediated suppression of host innate immune response
A0055036cellular_componentvirion membrane
A0061025biological_processmembrane fusion
A0075509biological_processendocytosis involved in viral entry into host cell
A0098670biological_processentry receptor-mediated virion attachment to host cell
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0016020cellular_componentmembrane
B0019031cellular_componentviral envelope
B0019062biological_processvirion attachment to host cell
B0019064biological_processfusion of virus membrane with host plasma membrane
B0019081biological_processviral translation
B0020002cellular_componenthost cell plasma membrane
B0039587biological_processsuppression by virus of host tetherin activity
B0039654biological_processfusion of virus membrane with host endosome membrane
B0039660molecular_functionstructural constituent of virion
B0042802molecular_functionidentical protein binding
B0043655cellular_componenthost extracellular space
B0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
B0044228cellular_componenthost cell surface
B0046598biological_processpositive regulation of viral entry into host cell
B0046718biological_processsymbiont entry into host cell
B0046789molecular_functionhost cell surface receptor binding
B0046813biological_processreceptor-mediated virion attachment to host cell
B0048018molecular_functionreceptor ligand activity
B0052170biological_processsymbiont-mediated suppression of host innate immune response
B0055036cellular_componentvirion membrane
B0061025biological_processmembrane fusion
B0075509biological_processendocytosis involved in viral entry into host cell
B0098670biological_processentry receptor-mediated virion attachment to host cell
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0016020cellular_componentmembrane
C0019031cellular_componentviral envelope
C0019062biological_processvirion attachment to host cell
C0019064biological_processfusion of virus membrane with host plasma membrane
C0019081biological_processviral translation
C0020002cellular_componenthost cell plasma membrane
C0039587biological_processsuppression by virus of host tetherin activity
C0039654biological_processfusion of virus membrane with host endosome membrane
C0039660molecular_functionstructural constituent of virion
C0042802molecular_functionidentical protein binding
C0043655cellular_componenthost extracellular space
C0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
C0044228cellular_componenthost cell surface
C0046598biological_processpositive regulation of viral entry into host cell
C0046718biological_processsymbiont entry into host cell
C0046789molecular_functionhost cell surface receptor binding
C0046813biological_processreceptor-mediated virion attachment to host cell
C0048018molecular_functionreceptor ligand activity
C0052170biological_processsymbiont-mediated suppression of host innate immune response
C0055036cellular_componentvirion membrane
C0061025biological_processmembrane fusion
C0075509biological_processendocytosis involved in viral entry into host cell
C0098670biological_processentry receptor-mediated virion attachment to host cell
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0016020cellular_componentmembrane
D0019031cellular_componentviral envelope
D0019062biological_processvirion attachment to host cell
D0019064biological_processfusion of virus membrane with host plasma membrane
D0019081biological_processviral translation
D0020002cellular_componenthost cell plasma membrane
D0039587biological_processsuppression by virus of host tetherin activity
D0039654biological_processfusion of virus membrane with host endosome membrane
D0039660molecular_functionstructural constituent of virion
D0042802molecular_functionidentical protein binding
D0043655cellular_componenthost extracellular space
D0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
D0044228cellular_componenthost cell surface
D0046598biological_processpositive regulation of viral entry into host cell
D0046718biological_processsymbiont entry into host cell
D0046789molecular_functionhost cell surface receptor binding
D0046813biological_processreceptor-mediated virion attachment to host cell
D0048018molecular_functionreceptor ligand activity
D0052170biological_processsymbiont-mediated suppression of host innate immune response
D0055036cellular_componentvirion membrane
D0061025biological_processmembrane fusion
D0075509biological_processendocytosis involved in viral entry into host cell
D0098670biological_processentry receptor-mediated virion attachment to host cell
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0007165biological_processsignal transduction
E0016020cellular_componentmembrane
E0019031cellular_componentviral envelope
E0019062biological_processvirion attachment to host cell
E0019064biological_processfusion of virus membrane with host plasma membrane
E0019081biological_processviral translation
E0020002cellular_componenthost cell plasma membrane
E0039587biological_processsuppression by virus of host tetherin activity
E0039654biological_processfusion of virus membrane with host endosome membrane
E0039660molecular_functionstructural constituent of virion
E0042802molecular_functionidentical protein binding
E0043655cellular_componenthost extracellular space
E0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
E0044228cellular_componenthost cell surface
E0046598biological_processpositive regulation of viral entry into host cell
E0046718biological_processsymbiont entry into host cell
E0046789molecular_functionhost cell surface receptor binding
E0046813biological_processreceptor-mediated virion attachment to host cell
E0048018molecular_functionreceptor ligand activity
E0052170biological_processsymbiont-mediated suppression of host innate immune response
E0055036cellular_componentvirion membrane
E0061025biological_processmembrane fusion
E0075509biological_processendocytosis involved in viral entry into host cell
E0098670biological_processentry receptor-mediated virion attachment to host cell
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0007165biological_processsignal transduction
F0016020cellular_componentmembrane
F0019031cellular_componentviral envelope
F0019062biological_processvirion attachment to host cell
F0019064biological_processfusion of virus membrane with host plasma membrane
F0019081biological_processviral translation
F0020002cellular_componenthost cell plasma membrane
F0039587biological_processsuppression by virus of host tetherin activity
F0039654biological_processfusion of virus membrane with host endosome membrane
F0039660molecular_functionstructural constituent of virion
F0042802molecular_functionidentical protein binding
F0043655cellular_componenthost extracellular space
F0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
F0044228cellular_componenthost cell surface
F0046598biological_processpositive regulation of viral entry into host cell
F0046718biological_processsymbiont entry into host cell
F0046789molecular_functionhost cell surface receptor binding
F0046813biological_processreceptor-mediated virion attachment to host cell
F0048018molecular_functionreceptor ligand activity
F0052170biological_processsymbiont-mediated suppression of host innate immune response
F0055036cellular_componentvirion membrane
F0061025biological_processmembrane fusion
F0075509biological_processendocytosis involved in viral entry into host cell
F0098670biological_processentry receptor-mediated virion attachment to host cell
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsSITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616
ChainResidueDetails
ASER686
BSER686
CSER686
DSER686
ESER686
FSER686

site_idSWS_FT_FI2
Number of Residues6
DetailsSITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616
ChainResidueDetails
ASER816
BSER816
CSER816
DSER816
ESER816
FSER816

site_idSWS_FT_FI3
Number of Residues30
DetailsCARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
AASN62
BPHE1075
CASN62
CASN123
CPHE718
CPHE802
CPHE1075
DASN62
DASN123
DPHE718
DPHE802
AASN123
DPHE1075
EASN62
EASN123
EPHE718
EPHE802
EPHE1075
FASN62
FASN123
FPHE718
FPHE802
APHE718
FPHE1075
APHE802
APHE1075
BASN62
BASN123
BPHE718
BPHE802

site_idSWS_FT_FI4
Number of Residues18
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
AASN75
DASN75
DLYS150
DGLU1195
EASN75
ELYS150
EGLU1195
FASN75
FLYS150
FGLU1195
ALYS150
AGLU1195
BASN75
BLYS150
BGLU1195
CASN75
CLYS150
CGLU1195

site_idSWS_FT_FI5
Number of Residues42
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
ACYS166
BILE332
BALA344
BCYS617
BASN658
BGLY1099
CCYS166
CGLY283
CILE332
CALA344
CCYS617
AGLY283
CASN658
CGLY1099
DCYS166
DGLY283
DILE332
DALA344
DCYS617
DASN658
DGLY1099
ECYS166
AILE332
EGLY283
EILE332
EALA344
ECYS617
EASN658
EGLY1099
FCYS166
FGLY283
FILE332
FALA344
AALA344
FCYS617
FASN658
FGLY1099
ACYS617
AASN658
AGLY1099
BCYS166
BGLY283

site_idSWS_FT_FI6
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
AILE235
EASN710
FILE235
FASN710
AASN710
BILE235
BASN710
CILE235
CASN710
DILE235
DASN710
EILE235

site_idSWS_FT_FI7
Number of Residues6
DetailsCARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391
ChainResidueDetails
AGLU324
BGLU324
CGLU324
DGLU324
EGLU324
FGLU324

site_idSWS_FT_FI8
Number of Residues6
DetailsCARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391
ChainResidueDetails
AILE326
BILE326
CILE326
DILE326
EILE326
FILE326

site_idSWS_FT_FI9
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
ATHR604
BTHR604
CTHR604
DTHR604
ETHR604
FTHR604

site_idSWS_FT_FI10
Number of Residues12
DetailsCARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583
ChainResidueDetails
AGLN677
ELYS679
FGLN677
FLYS679
ALYS679
BGLN677
BLYS679
CGLN677
CLYS679
DGLN677
DLYS679
EGLN677

site_idSWS_FT_FI11
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
AASN1135
BASN1135
CASN1135
DASN1135
EASN1135
FASN1135

site_idSWS_FT_FI12
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
AHIS1159
EALA1174
FHIS1159
FALA1174
AALA1174
BHIS1159
BALA1174
CHIS1159
CALA1174
DHIS1159
DALA1174
EHIS1159

224201

PDB entries from 2024-08-28

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