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8JMH

The cryo-EM structure of insect gustatory receptor Gr64a from Drosophila melanogaster in complex with sucrose

Functional Information from GO Data
ChainGOidnamespacecontents
A0001582biological_processdetection of chemical stimulus involved in sensory perception of sweet taste
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0007637biological_processproboscis extension reflex
A0008527molecular_functiontaste receptor activity
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0033041molecular_functionsweet taste receptor activity
A0034220biological_processmonoatomic ion transmembrane transport
A0050909biological_processsensory perception of taste
A0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
A0050916biological_processsensory perception of sweet taste
A0170023molecular_functionionotropic sweet taste receptor activity
B0001582biological_processdetection of chemical stimulus involved in sensory perception of sweet taste
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007637biological_processproboscis extension reflex
B0008527molecular_functiontaste receptor activity
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0033041molecular_functionsweet taste receptor activity
B0034220biological_processmonoatomic ion transmembrane transport
B0050909biological_processsensory perception of taste
B0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
B0050916biological_processsensory perception of sweet taste
B0170023molecular_functionionotropic sweet taste receptor activity
C0001582biological_processdetection of chemical stimulus involved in sensory perception of sweet taste
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007637biological_processproboscis extension reflex
C0008527molecular_functiontaste receptor activity
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0033041molecular_functionsweet taste receptor activity
C0034220biological_processmonoatomic ion transmembrane transport
C0050909biological_processsensory perception of taste
C0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
C0050916biological_processsensory perception of sweet taste
C0170023molecular_functionionotropic sweet taste receptor activity
D0001582biological_processdetection of chemical stimulus involved in sensory perception of sweet taste
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007637biological_processproboscis extension reflex
D0008527molecular_functiontaste receptor activity
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0033041molecular_functionsweet taste receptor activity
D0034220biological_processmonoatomic ion transmembrane transport
D0050909biological_processsensory perception of taste
D0050912biological_processdetection of chemical stimulus involved in sensory perception of taste
D0050916biological_processsensory perception of sweet taste
D0170023molecular_functionionotropic sweet taste receptor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues440
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250
ChainResidueDetails
AMET1-ARG61
CTHR117-ASN128
CSER207-LEU238
CASN343-TYR351
DMET1-ARG61
DTHR117-ASN128
DSER207-LEU238
DASN343-TYR351
ATHR117-ASN128
ASER207-LEU238
AASN343-TYR351
BMET1-ARG61
BTHR117-ASN128
BSER207-LEU238
BASN343-TYR351
CMET1-ARG61

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
AALA62-ARG82
BALA62-ARG82
CALA62-ARG82
DALA62-ARG82

site_idSWS_FT_FI3
Number of Residues764
DetailsTOPO_DOM: Extracellular => ECO:0000250
ChainResidueDetails
AGLU83-SER95
CLYS150-ALA185
CTRP260-SER321
CALA373-ALA456
DGLU83-SER95
DLYS150-ALA185
DTRP260-SER321
DALA373-ALA456
ALYS150-ALA185
ATRP260-SER321
AALA373-ALA456
BGLU83-SER95
BLYS150-ALA185
BTRP260-SER321
BALA373-ALA456
CGLU83-SER95

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
AILE96-PHE116
BILE96-PHE116
CILE96-PHE116
DILE96-PHE116

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
APHE129-ALA149
BPHE129-ALA149
CPHE129-ALA149
DPHE129-ALA149

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
AALA186-LEU206
BALA186-LEU206
CALA186-LEU206
DALA186-LEU206

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
ALEU239-VAL259
BLEU239-VAL259
CLEU239-VAL259
DLEU239-VAL259

site_idSWS_FT_FI8
Number of Residues80
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
ALEU322-PHE342
BLEU322-PHE342
CLEU322-PHE342
DLEU322-PHE342

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
AILE352-ALA372
BILE352-ALA372
CILE352-ALA372
DILE352-ALA372

site_idSWS_FT_FI10
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN177
BASN177
CASN177
DASN177

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PDB entries from 2024-07-10

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