8JIN

The local refined map of XBB spike protein (S) in complex with bispecific antibody G7-Fc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
A	0019031	cellular_component	viral envelope
A	0019062	biological_process	virion attachment to host cell
A	0019064	biological_process	fusion of virus membrane with host plasma membrane
A	0019081	biological_process	viral translation
A	0020002	cellular_component	host cell plasma membrane
A	0033644	cellular_component	host cell membrane
A	0039587	biological_process	symbiont-mediated-mediated suppression of host tetherin activity
A	0039654	biological_process	fusion of virus membrane with host endosome membrane
A	0039660	molecular_function	structural constituent of virion
A	0039663	biological_process	membrane fusion involved in viral entry into host cell
A	0042802	molecular_function	identical protein binding
A	0043655	cellular_component	host extracellular space
A	0044173	cellular_component	host cell endoplasmic reticulum-Golgi intermediate compartment membrane
A	0044228	cellular_component	host cell surface
A	0044423	cellular_component	virion component
A	0046598	biological_process	positive regulation of viral entry into host cell
A	0046718	biological_process	symbiont entry into host cell
A	0046789	molecular_function	host cell surface receptor binding
A	0046813	biological_process	receptor-mediated virion attachment to host cell
A	0048018	molecular_function	receptor ligand activity
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
A	0055036	cellular_component	virion membrane
A	0061025	biological_process	membrane fusion
A	0075509	biological_process	endocytosis involved in viral entry into host cell
A	0098670	biological_process	entry receptor-mediated virion attachment to host cell
A	0141146	biological_process	symbiont-mediated disruption of host tissue

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	193
Details	Domain: {"description":"BetaCoV S1-CTD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01269","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32132184","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Region: {"description":"Integrin-binding motif;","evidences":[{"source":"PubMed","id":"33102950","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	71
Details	Region: {"description":"Receptor-binding motif; binding to human ACE2","evidences":[{"source":"UniProtKB","id":"P59594","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Region: {"description":"Immunodominant HLA epitope recognized by the CD8+; called NF9 peptide","evidences":[{"source":"PubMed","id":"34171266","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	35
Details	Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"35108439","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04099","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32155444","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32363391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32366695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32979942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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