8JGS
Cryo-EM structure of apo state mClC-3_I607T
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 634 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P35523 |
| Chain | Residue | Details |
| A | MET-63-ALA61 | |
| A | GLY561-ASN754 | |
| B | MET-63-ALA61 | |
| B | GLY561-ASN754 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 434 |
| Details | TRANSMEM: Helical => ECO:0000250|UniProtKB:P35523 |
| Chain | Residue | Details |
| A | TRP62-SER99 | |
| A | TYR542-PHE560 | |
| B | TRP62-SER99 | |
| B | MET145-PHE168 | |
| B | GLY194-GLY212 | |
| B | GLU218-PRO237 | |
| B | LEU285-ASN303 | |
| B | PHE327-ARG352 | |
| B | PHE359-PHE379 | |
| B | ILE436-ILE456 | |
| B | GLY461-ALA480 | |
| A | MET145-PHE168 | |
| B | TYR542-PHE560 | |
| A | GLY194-GLY212 | |
| A | GLU218-PRO237 | |
| A | LEU285-ASN303 | |
| A | PHE327-ARG352 | |
| A | PHE359-PHE379 | |
| A | ILE436-ILE456 | |
| A | GLY461-ALA480 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 104 |
| Details | INTRAMEM: Helical => ECO:0000250|UniProtKB:P35523 |
| Chain | Residue | Details |
| A | ILE177-LEU184 | |
| B | THR526-THR537 | |
| A | VAL249-ALA261 | |
| A | PRO265-LEU273 | |
| A | GLY508-VAL522 | |
| A | THR526-THR537 | |
| B | ILE177-LEU184 | |
| B | VAL249-ALA261 | |
| B | PRO265-LEU273 | |
| B | GLY508-VAL522 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | INTRAMEM: Note=Loop between two helices => ECO:0000250|UniProtKB:P35523 |
| Chain | Residue | Details |
| A | GLY538-GLU541 | |
| B | GLY538-GLU541 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | SER175 | |
| B | THR732 | |
| A | PHE463 | |
| A | TYR566 | |
| A | TYR625 | |
| A | THR732 | |
| B | SER175 | |
| B | PHE463 | |
| B | TYR566 | |
| B | TYR625 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU218 | |
| B | GLU218 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Mediates proton transfer from the protein to the inner aqueous phase => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU275 | |
| B | GLU275 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN113 | |
| A | ASN387 | |
| A | ASN415 | |
| B | ASN113 | |
| B | ASN387 | |
| B | ASN415 |
