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8JGL

Cryo-EM structure of mClC-3 with AMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0005247molecular_functionvoltage-gated chloride channel activity
A0005254molecular_functionchloride channel activity
A0005524molecular_functionATP binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006911biological_processphagocytosis, engulfment
A0008021cellular_componentsynaptic vesicle
A0008344biological_processadult locomotory behavior
A0009897cellular_componentexternal side of plasma membrane
A0010008cellular_componentendosome membrane
A0012506cellular_componentvesicle membrane
A0015297molecular_functionantiporter activity
A0030141cellular_componentsecretory granule
A0030165molecular_functionPDZ domain binding
A0030658cellular_componenttransport vesicle membrane
A0030672cellular_componentsynaptic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0035249biological_processsynaptic transmission, glutamatergic
A0042581cellular_componentspecific granule
A0043231cellular_componentintracellular membrane-bounded organelle
A0043679cellular_componentaxon terminus
A0045335cellular_componentphagocytic vesicle
A0045494biological_processphotoreceptor cell maintenance
A0045794biological_processnegative regulation of cell volume
A0051932biological_processsynaptic transmission, GABAergic
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0060077cellular_componentinhibitory synapse
A0070050biological_processneuron cellular homeostasis
A0072320molecular_functionvolume-sensitive chloride channel activity
A0097401biological_processsynaptic vesicle lumen acidification
A0098978cellular_componentglutamatergic synapse
A0098982cellular_componentGABA-ergic synapse
A1902476biological_processchloride transmembrane transport
A1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
B0005247molecular_functionvoltage-gated chloride channel activity
B0005254molecular_functionchloride channel activity
B0005524molecular_functionATP binding
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006911biological_processphagocytosis, engulfment
B0008021cellular_componentsynaptic vesicle
B0008344biological_processadult locomotory behavior
B0009897cellular_componentexternal side of plasma membrane
B0010008cellular_componentendosome membrane
B0012506cellular_componentvesicle membrane
B0015297molecular_functionantiporter activity
B0030141cellular_componentsecretory granule
B0030165molecular_functionPDZ domain binding
B0030658cellular_componenttransport vesicle membrane
B0030672cellular_componentsynaptic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0035249biological_processsynaptic transmission, glutamatergic
B0042581cellular_componentspecific granule
B0043231cellular_componentintracellular membrane-bounded organelle
B0043679cellular_componentaxon terminus
B0045335cellular_componentphagocytic vesicle
B0045494biological_processphotoreceptor cell maintenance
B0045794biological_processnegative regulation of cell volume
B0051932biological_processsynaptic transmission, GABAergic
B0055037cellular_componentrecycling endosome
B0055038cellular_componentrecycling endosome membrane
B0060077cellular_componentinhibitory synapse
B0070050biological_processneuron cellular homeostasis
B0072320molecular_functionvolume-sensitive chloride channel activity
B0097401biological_processsynaptic vesicle lumen acidification
B0098978cellular_componentglutamatergic synapse
B0098982cellular_componentGABA-ergic synapse
B1902476biological_processchloride transmembrane transport
B1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues634
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P35523
ChainResidueDetails
AMET1-ALA125
AGLY625-ASN818
BMET1-ALA125
BGLY625-ASN818

site_idSWS_FT_FI2
Number of Residues434
DetailsTRANSMEM: Helical => ECO:0000250|UniProtKB:P35523
ChainResidueDetails
ATRP126-SER163
ATYR606-PHE624
BTRP126-SER163
BMET209-PHE232
BGLY258-GLY276
BGLU282-PRO301
BLEU349-ASN367
BPHE391-ARG416
BPHE423-PHE443
BILE500-ILE520
BGLY525-ALA544
AMET209-PHE232
BTYR606-PHE624
AGLY258-GLY276
AGLU282-PRO301
ALEU349-ASN367
APHE391-ARG416
APHE423-PHE443
AILE500-ILE520
AGLY525-ALA544

site_idSWS_FT_FI3
Number of Residues104
DetailsINTRAMEM: Helical => ECO:0000250|UniProtKB:P35523
ChainResidueDetails
AILE241-LEU248
BTHR590-THR601
AVAL313-ALA325
APRO329-LEU337
AGLY572-VAL586
ATHR590-THR601
BILE241-LEU248
BVAL313-ALA325
BPRO329-LEU337
BGLY572-VAL586

site_idSWS_FT_FI4
Number of Residues6
DetailsINTRAMEM: Note=Loop between two helices => ECO:0000250|UniProtKB:P35523
ChainResidueDetails
AGLY602-GLU605
BGLY602-GLU605

site_idSWS_FT_FI5
Number of Residues10
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ASER239
BTHR796
APHE527
ATYR630
ATYR689
ATHR796
BSER239
BPHE527
BTYR630
BTYR689

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport => ECO:0000250
ChainResidueDetails
AGLU282
BGLU282

site_idSWS_FT_FI7
Number of Residues2
DetailsSITE: Mediates proton transfer from the protein to the inner aqueous phase => ECO:0000250
ChainResidueDetails
AGLU339
BGLU339

site_idSWS_FT_FI8
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN177
AASN451
AASN479
BASN177
BASN451
BASN479

227344

PDB entries from 2024-11-13

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