Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8JGL

Cryo-EM structure of mClC-3 with AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005216	molecular_function	monoatomic ion channel activity
A	0005244	molecular_function	voltage-gated monoatomic ion channel activity
A	0005247	molecular_function	voltage-gated chloride channel activity
A	0005254	molecular_function	chloride channel activity
A	0005524	molecular_function	ATP binding
A	0005765	cellular_component	lysosomal membrane
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005770	cellular_component	late endosome
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0006911	biological_process	phagocytosis, engulfment
A	0008021	cellular_component	synaptic vesicle
A	0008344	biological_process	adult locomotory behavior
A	0009897	cellular_component	external side of plasma membrane
A	0010008	cellular_component	endosome membrane
A	0012506	cellular_component	vesicle membrane
A	0015108	molecular_function	chloride transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0030141	cellular_component	secretory granule
A	0030165	molecular_function	PDZ domain binding
A	0030658	cellular_component	transport vesicle membrane
A	0030672	cellular_component	synaptic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031901	cellular_component	early endosome membrane
A	0031902	cellular_component	late endosome membrane
A	0035249	biological_process	synaptic transmission, glutamatergic
A	0042581	cellular_component	specific granule
A	0043679	cellular_component	axon terminus
A	0045211	cellular_component	postsynaptic membrane
A	0045335	cellular_component	phagocytic vesicle
A	0045494	biological_process	photoreceptor cell maintenance
A	0045794	biological_process	negative regulation of cell volume
A	0051932	biological_process	synaptic transmission, GABAergic
A	0055037	cellular_component	recycling endosome
A	0055038	cellular_component	recycling endosome membrane
A	0055085	biological_process	transmembrane transport
A	0060077	cellular_component	inhibitory synapse
A	0062158	molecular_function	chloride:proton antiporter activity
A	0070050	biological_process	neuron cellular homeostasis
A	0072320	molecular_function	volume-sensitive chloride channel activity
A	0097401	biological_process	synaptic vesicle lumen acidification
A	0098978	cellular_component	glutamatergic synapse
A	0098982	cellular_component	GABA-ergic synapse
A	1902476	biological_process	chloride transmembrane transport
A	1903428	biological_process	positive regulation of reactive oxygen species biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0005216	molecular_function	monoatomic ion channel activity
B	0005244	molecular_function	voltage-gated monoatomic ion channel activity
B	0005247	molecular_function	voltage-gated chloride channel activity
B	0005254	molecular_function	chloride channel activity
B	0005524	molecular_function	ATP binding
B	0005765	cellular_component	lysosomal membrane
B	0005768	cellular_component	endosome
B	0005769	cellular_component	early endosome
B	0005770	cellular_component	late endosome
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006821	biological_process	chloride transport
B	0006911	biological_process	phagocytosis, engulfment
B	0008021	cellular_component	synaptic vesicle
B	0008344	biological_process	adult locomotory behavior
B	0009897	cellular_component	external side of plasma membrane
B	0010008	cellular_component	endosome membrane
B	0012506	cellular_component	vesicle membrane
B	0015108	molecular_function	chloride transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0030141	cellular_component	secretory granule
B	0030165	molecular_function	PDZ domain binding
B	0030658	cellular_component	transport vesicle membrane
B	0030672	cellular_component	synaptic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0035249	biological_process	synaptic transmission, glutamatergic
B	0042581	cellular_component	specific granule
B	0043679	cellular_component	axon terminus
B	0045211	cellular_component	postsynaptic membrane
B	0045335	cellular_component	phagocytic vesicle
B	0045494	biological_process	photoreceptor cell maintenance
B	0045794	biological_process	negative regulation of cell volume
B	0051932	biological_process	synaptic transmission, GABAergic
B	0055037	cellular_component	recycling endosome
B	0055038	cellular_component	recycling endosome membrane
B	0055085	biological_process	transmembrane transport
B	0060077	cellular_component	inhibitory synapse
B	0062158	molecular_function	chloride:proton antiporter activity
B	0070050	biological_process	neuron cellular homeostasis
B	0072320	molecular_function	volume-sensitive chloride channel activity
B	0097401	biological_process	synaptic vesicle lumen acidification
B	0098978	cellular_component	glutamatergic synapse
B	0098982	cellular_component	GABA-ergic synapse
B	1902476	biological_process	chloride transmembrane transport
B	1903428	biological_process	positive regulation of reactive oxygen species biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	434
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P35523","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	104
Details	Intramembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P35523","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Intramembrane: {"description":"Note=Loop between two helices","evidences":[{"source":"UniProtKB","id":"P35523","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	128
Details	Domain: {"description":"CBS 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00703","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Motif: {"description":"Selectivity filter part_1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Motif: {"description":"Selectivity filter part_2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Motif: {"description":"Selectivity filter part_3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"Mediates proton transfer from the protein to the inner aqueous phase","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)