8JFT
Cryo-EM structure of SaCas9-AcrIIA15 CTD-sgRNA complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003677 | molecular_function | DNA binding |
A | 0003723 | molecular_function | RNA binding |
A | 0004519 | molecular_function | endonuclease activity |
A | 0043571 | biological_process | maintenance of CRISPR repeat elements |
A | 0046872 | molecular_function | metal ion binding |
A | 0051607 | biological_process | defense response to virus |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: For RuvC-like nuclease domain => ECO:0000305|PubMed:26317473 |
Chain | Residue | Details |
A | ASP10 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor for HNH nuclease domain => ECO:0000305|PubMed:26317473 |
Chain | Residue | Details |
A | HIS557 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01480 |
Chain | Residue | Details |
A | ASP10 | |
A | GLU477 | |
A | GLU481 | |
A | HIS701 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:26317473 |
Chain | Residue | Details |
A | TYR789 |