8JF1
Human sodium-dependent vitamin C transporter 1 in an apo occluded state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0007420 | biological_process | brain development |
| A | 0008520 | molecular_function | L-ascorbate:sodium symporter activity |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0015081 | molecular_function | sodium ion transmembrane transporter activity |
| A | 0015143 | molecular_function | urate transmembrane transporter activity |
| A | 0015205 | molecular_function | nucleobase transmembrane transporter activity |
| A | 0015229 | molecular_function | L-ascorbic acid transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015747 | biological_process | urate transport |
| A | 0015851 | biological_process | nucleobase transport |
| A | 0015882 | biological_process | L-ascorbic acid transmembrane transport |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0019852 | biological_process | L-ascorbic acid metabolic process |
| A | 0030324 | biological_process | lung development |
| A | 0033300 | molecular_function | dehydroascorbic acid transmembrane transporter activity |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0043229 | cellular_component | intracellular organelle |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070837 | biological_process | dehydroascorbic acid transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 137 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:19379732 |
| Chain | Residue | Details |
| A | MET1-TYR52 | |
| A | ASP512-VAL598 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 237 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU53-GLY73 | |
| A | ILE427-LEU447 | |
| A | LEU458-ASN478 | |
| A | GLN491-LEU511 | |
| A | LEU82-ILE102 | |
| A | LEU104-LEU124 | |
| A | ILE160-LEU180 | |
| A | GLY208-SER225 | |
| A | ILE251-LEU271 | |
| A | LEU313-ILE333 | |
| A | GLY359-SER379 | |
| A | GLY403-LEU423 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 87 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | HIS74-GLN81 | |
| A | GLU125-ALA159 | |
| A | GLN226-ARG229 | |
| A | LEU244-GLN250 | |
| A | GLU334-ARG358 | |
| A | PRO424-PRO426 | |
| A | PRO479-ASP490 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 98 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG103 | |
| A | ASN181-ALA207 | |
| A | THR272-GLY312 | |
| A | THR380-TYR402 | |
| A | GLN448-ASN457 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 13 |
| Details | INTRAMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN230-GLY243 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9Z2J0 |
| Chain | Residue | Details |
| A | THR591 | |
| A | THR596 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9Z2J0 |
| Chain | Residue | Details |
| A | SER593 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19379732 |
| Chain | Residue | Details |
| A | ASN138 | |
| A | ASN144 |
