8JDF
Crystal structure of H405A mLDHD in complex with D-lactate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004457 | molecular_function | lactate dehydrogenase activity |
| A | 0004458 | molecular_function | D-lactate dehydrogenase (cytochrome) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006754 | biological_process | ATP biosynthetic process |
| A | 0008720 | molecular_function | D-lactate dehydrogenase (NAD+) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0071949 | molecular_function | FAD binding |
| A | 0140170 | molecular_function | D-lactate dehydrogenase (FAD) activity |
| A | 0140174 | molecular_function | (2R)-2-hydroxycarboxylate dehydrogenase activity |
| A | 1903457 | biological_process | lactate catabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 180 |
| Details | Domain: {"description":"FAD-binding PCMH-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00718","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"37863926","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37863926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37863926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37863926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JDS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37863926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8JDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8JDZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23576753","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
