8JCZ

Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495, NAM563, and LY2389575 (dimerization mode III)

Functional Information from GO Data

Chain	GOid	namespace	contents
2	0000413	biological_process	protein peptidyl-prolyl isomerization
2	0001641	molecular_function	group II metabotropic glutamate receptor activity
2	0003007	biological_process	heart morphogenesis
2	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
2	0004930	molecular_function	G protein-coupled receptor activity
2	0005160	molecular_function	transforming growth factor beta receptor binding
2	0005246	molecular_function	calcium channel regulator activity
2	0005515	molecular_function	protein binding
2	0005527	molecular_function	macrolide binding
2	0005528	molecular_function	FK506 binding
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005886	cellular_component	plasma membrane
2	0006457	biological_process	protein folding
2	0006458	biological_process	'de novo' protein folding
2	0007186	biological_process	G protein-coupled receptor signaling pathway
2	0007194	biological_process	negative regulation of adenylate cyclase activity
2	0007196	biological_process	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
2	0007215	biological_process	glutamate receptor signaling pathway
2	0007216	biological_process	G protein-coupled glutamate receptor signaling pathway
2	0007268	biological_process	chemical synaptic transmission
2	0008066	molecular_function	glutamate receptor activity
2	0010467	biological_process	gene expression
2	0014047	biological_process	glutamate secretion
2	0014048	biological_process	regulation of glutamate secretion
2	0014059	biological_process	regulation of dopamine secretion
2	0014802	cellular_component	terminal cisterna
2	0014809	biological_process	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
2	0016020	cellular_component	membrane
2	0016247	molecular_function	channel regulator activity
2	0016529	cellular_component	sarcoplasmic reticulum
2	0022417	biological_process	protein maturation by protein folding
2	0030018	cellular_component	Z disc
2	0030424	cellular_component	axon
2	0030425	cellular_component	dendrite
2	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
2	0030547	molecular_function	signaling receptor inhibitor activity
2	0032092	biological_process	positive regulation of protein binding
2	0032880	biological_process	regulation of protein localization
2	0032926	biological_process	negative regulation of activin receptor signaling pathway
2	0033017	cellular_component	sarcoplasmic reticulum membrane
2	0033554	biological_process	cellular response to stress
2	0034713	molecular_function	type I transforming growth factor beta receptor binding
2	0035095	biological_process	behavioral response to nicotine
2	0042026	biological_process	protein refolding
2	0042110	biological_process	T cell activation
2	0042220	biological_process	response to cocaine
2	0042734	cellular_component	presynaptic membrane
2	0042995	cellular_component	cell projection
2	0043005	cellular_component	neuron projection
2	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
2	0044325	molecular_function	transmembrane transporter binding
2	0045202	cellular_component	synapse
2	0045211	cellular_component	postsynaptic membrane
2	0050776	biological_process	regulation of immune response
2	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
2	0051966	biological_process	regulation of synaptic transmission, glutamatergic
2	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
2	0060292	biological_process	long-term synaptic depression
2	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
2	0060347	biological_process	heart trabecula formation
2	0070411	molecular_function	I-SMAD binding
2	0070588	biological_process	calcium ion transmembrane transport
2	0070697	molecular_function	activin receptor binding
2	0090461	biological_process	intracellular glutamate homeostasis
2	0097110	molecular_function	scaffold protein binding
2	0097435	biological_process	supramolecular fiber organization
2	0097449	cellular_component	astrocyte projection
2	0098562	cellular_component	cytoplasmic side of membrane
2	0098978	cellular_component	glutamatergic synapse
2	0099171	biological_process	presynaptic modulation of chemical synaptic transmission
2	1902991	biological_process	regulation of amyloid precursor protein catabolic process
2	1990000	biological_process	amyloid fibril formation
2	1990425	cellular_component	ryanodine receptor complex
2	2001023	biological_process	regulation of response to drug
3	0001641	molecular_function	group II metabotropic glutamate receptor activity
3	0004930	molecular_function	G protein-coupled receptor activity
3	0005246	molecular_function	calcium channel regulator activity
3	0005886	cellular_component	plasma membrane
3	0007186	biological_process	G protein-coupled receptor signaling pathway
3	0007194	biological_process	negative regulation of adenylate cyclase activity
3	0007196	biological_process	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
3	0007216	biological_process	G protein-coupled glutamate receptor signaling pathway
3	0007268	biological_process	chemical synaptic transmission
3	0008066	molecular_function	glutamate receptor activity
3	0010467	biological_process	gene expression
3	0014069	cellular_component	postsynaptic density
3	0016020	cellular_component	membrane
3	0030424	cellular_component	axon
3	0033554	biological_process	cellular response to stress
3	0042734	cellular_component	presynaptic membrane
3	0043005	cellular_component	neuron projection
3	0043197	cellular_component	dendritic spine
3	0044877	molecular_function	protein-containing complex binding
3	0045211	cellular_component	postsynaptic membrane
3	0051966	biological_process	regulation of synaptic transmission, glutamatergic
3	0097110	molecular_function	scaffold protein binding
3	0097449	cellular_component	astrocyte projection
3	0098978	cellular_component	glutamatergic synapse
3	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission

Functional Information from PROSITE/UniProt

site_id	PS00979
Number of Residues	19
Details	G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLrLFqIPQISyASTS

Chain	Residue	Details
3	VAL157-SER175
2	VAL151-SER169

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site_id	PS00980
Number of Residues	23
Details	G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCWiCipCepyeYla...DefTCmdC

Chain	Residue	Details
3	CYS527-CYS549
2	CYS518-CYS540

---

site_id	PS00981
Number of Residues	11
Details	G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfIGFTM

Chain	Residue	Details
3	PHE765-MET775
2	PHE756-MET766

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	596
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
3	LEU23-TRP576
3	LYS635-ARG645
3	GLU710-ASP734
3	SER793-THR802

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
3	ALA577-ILE599

---

site_id	SWS_FT_FI3
Number of Residues	98
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
3	LYS600-GLU613
3	CYS665-GLN688
3	LYS757-LYS769
3	GLN829-LEU879

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
3	LEU614-ALA634

---

site_id	SWS_FT_FI5
Number of Residues	18
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
3	LEU646-ASN664

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
3	VAL689-LEU709

---

site_id	SWS_FT_FI7
Number of Residues	21
Details	TRANSMEM: Helical; Name=5 => ECO:0000255

Chain	Residue	Details
3	SER735-PHE756

---

site_id	SWS_FT_FI8
Number of Residues	22
Details	TRANSMEM: Helical; Name=6 => ECO:0000255

Chain	Residue	Details
3	PHE770-THR792

---

site_id	SWS_FT_FI9
Number of Residues	25
Details	TRANSMEM: Helical; Name=7 => ECO:0000255

Chain	Residue	Details
3	MET803-PHE828

---

site_id	SWS_FT_FI10
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
3	SER151
3	ALA172
3	TYR222
3	ASP301
3	LYS389

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
3	ASN209
3	ASN292
3	ASN414
3	ASN439
2	ASN547

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P26883

Chain	Residue	Details
2	LYS932

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 362

Chain	Residue	Details
2	TYR906	electrostatic destabiliser, steric role
2	PHE916	electrostatic destabiliser, polar/non-polar interaction, steric role
2	ASP917	electrostatic stabiliser, steric role
2	ILE936	electrostatic stabiliser, steric role
2	TYR962	electrostatic stabiliser, steric role
2	PHE979	electrostatic destabiliser, polar/non-polar interaction, steric role

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