8JAV

Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (tetramer)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003777	molecular_function	microtubule motor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005875	cellular_component	microtubule associated complex
A	0006886	biological_process	intracellular protein transport
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0016567	biological_process	protein ubiquitination
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0046907	biological_process	intracellular transport
A	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
A	0160276	biological_process	negative regulation of beige fat cell differentiation
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	0003777	molecular_function	microtubule motor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005875	cellular_component	microtubule associated complex
B	0006886	biological_process	intracellular protein transport
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0046907	biological_process	intracellular transport
B	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
B	0160276	biological_process	negative regulation of beige fat cell differentiation
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000151	cellular_component	ubiquitin ligase complex
C	0001222	molecular_function	transcription corepressor binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0006368	biological_process	transcription elongation by RNA polymerase II
C	0016567	biological_process	protein ubiquitination
C	0030891	cellular_component	VCB complex
C	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
C	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0065003	biological_process	protein-containing complex assembly
C	0070449	cellular_component	elongin complex
C	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
C	0140958	biological_process	target-directed miRNA degradation
C	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
C	2000104	biological_process	negative regulation of DNA-templated DNA replication
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0000082	biological_process	G1/S transition of mitotic cell cycle
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0004842	molecular_function	ubiquitin-protein transferase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010498	biological_process	proteasomal protein catabolic process
E	0016567	biological_process	protein ubiquitination
E	0019005	cellular_component	SCF ubiquitin ligase complex
E	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
E	0031461	cellular_component	cullin-RING ubiquitin ligase complex
E	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0031981	cellular_component	nuclear lumen
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0072344	biological_process	rescue of stalled ribosome
E	0097193	biological_process	intrinsic apoptotic signaling pathway
E	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
E	0160072	molecular_function	ubiquitin ligase complex scaffold activity
E	0160276	biological_process	negative regulation of beige fat cell differentiation
E	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
E	2000104	biological_process	negative regulation of DNA-templated DNA replication
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000151	cellular_component	ubiquitin ligase complex
G	0001222	molecular_function	transcription corepressor binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006351	biological_process	DNA-templated transcription
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006368	biological_process	transcription elongation by RNA polymerase II
G	0016567	biological_process	protein ubiquitination
G	0030891	cellular_component	VCB complex
G	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
G	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0065003	biological_process	protein-containing complex assembly
G	0070449	cellular_component	elongin complex
G	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
G	0140958	biological_process	target-directed miRNA degradation
G	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
G	2000104	biological_process	negative regulation of DNA-templated DNA replication
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0000082	biological_process	G1/S transition of mitotic cell cycle
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0004842	molecular_function	ubiquitin-protein transferase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0010498	biological_process	proteasomal protein catabolic process
I	0016567	biological_process	protein ubiquitination
I	0019005	cellular_component	SCF ubiquitin ligase complex
I	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
I	0031461	cellular_component	cullin-RING ubiquitin ligase complex
I	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0031981	cellular_component	nuclear lumen
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0072344	biological_process	rescue of stalled ribosome
I	0097193	biological_process	intrinsic apoptotic signaling pathway
I	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
I	0160072	molecular_function	ubiquitin ligase complex scaffold activity
I	0160276	biological_process	negative regulation of beige fat cell differentiation
I	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
I	2000104	biological_process	negative regulation of DNA-templated DNA replication
J	0003777	molecular_function	microtubule motor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005875	cellular_component	microtubule associated complex
J	0006886	biological_process	intracellular protein transport
J	0015031	biological_process	protein transport
J	0016020	cellular_component	membrane
J	0016567	biological_process	protein ubiquitination
J	0030659	cellular_component	cytoplasmic vesicle membrane
J	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0046907	biological_process	intracellular transport
J	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
J	0160276	biological_process	negative regulation of beige fat cell differentiation
J	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
K	0003777	molecular_function	microtubule motor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0005875	cellular_component	microtubule associated complex
K	0006886	biological_process	intracellular protein transport
K	0015031	biological_process	protein transport
K	0016020	cellular_component	membrane
K	0016567	biological_process	protein ubiquitination
K	0030659	cellular_component	cytoplasmic vesicle membrane
K	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0046907	biological_process	intracellular transport
K	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
K	0160276	biological_process	negative regulation of beige fat cell differentiation
K	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
L	0000082	biological_process	G1/S transition of mitotic cell cycle
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0004842	molecular_function	ubiquitin-protein transferase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0010498	biological_process	proteasomal protein catabolic process
L	0016567	biological_process	protein ubiquitination
L	0019005	cellular_component	SCF ubiquitin ligase complex
L	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L	0031461	cellular_component	cullin-RING ubiquitin ligase complex
L	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0031981	cellular_component	nuclear lumen
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0072344	biological_process	rescue of stalled ribosome
L	0097193	biological_process	intrinsic apoptotic signaling pathway
L	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
L	0160072	molecular_function	ubiquitin ligase complex scaffold activity
L	0160276	biological_process	negative regulation of beige fat cell differentiation
L	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
L	2000104	biological_process	negative regulation of DNA-templated DNA replication
M	0000122	biological_process	negative regulation of transcription by RNA polymerase II
M	0000151	cellular_component	ubiquitin ligase complex
M	0001222	molecular_function	transcription corepressor binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006351	biological_process	DNA-templated transcription
M	0006367	biological_process	transcription initiation at RNA polymerase II promoter
M	0006368	biological_process	transcription elongation by RNA polymerase II
M	0016567	biological_process	protein ubiquitination
M	0030891	cellular_component	VCB complex
M	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
M	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
M	0031625	molecular_function	ubiquitin protein ligase binding
M	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0065003	biological_process	protein-containing complex assembly
M	0070449	cellular_component	elongin complex
M	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
M	0140958	biological_process	target-directed miRNA degradation
M	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
M	2000104	biological_process	negative regulation of DNA-templated DNA replication
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Q	0000151	cellular_component	ubiquitin ligase complex
Q	0001222	molecular_function	transcription corepressor binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006351	biological_process	DNA-templated transcription
Q	0006367	biological_process	transcription initiation at RNA polymerase II promoter
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0016567	biological_process	protein ubiquitination
Q	0030891	cellular_component	VCB complex
Q	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
Q	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0065003	biological_process	protein-containing complex assembly
Q	0070449	cellular_component	elongin complex
Q	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Q	0140958	biological_process	target-directed miRNA degradation
Q	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
Q	2000104	biological_process	negative regulation of DNA-templated DNA replication
R	0000082	biological_process	G1/S transition of mitotic cell cycle
R	0000122	biological_process	negative regulation of transcription by RNA polymerase II
R	0000165	biological_process	MAPK cascade
R	0000209	biological_process	protein polyubiquitination
R	0004842	molecular_function	ubiquitin-protein transferase activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005794	cellular_component	Golgi apparatus
R	0005813	cellular_component	centrosome
R	0005829	cellular_component	cytosol
R	0006281	biological_process	DNA repair
R	0006283	biological_process	transcription-coupled nucleotide-excision repair
R	0006289	biological_process	nucleotide-excision repair
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006513	biological_process	protein monoubiquitination
R	0006879	biological_process	intracellular iron ion homeostasis
R	0006974	biological_process	DNA damage response
R	0007283	biological_process	spermatogenesis
R	0007346	biological_process	regulation of mitotic cell cycle
R	0008270	molecular_function	zinc ion binding
R	0008283	biological_process	cell population proliferation
R	0010506	biological_process	regulation of autophagy
R	0010564	biological_process	regulation of cell cycle process
R	0010824	biological_process	regulation of centrosome duplication
R	0014033	biological_process	neural crest cell differentiation
R	0016567	biological_process	protein ubiquitination
R	0016740	molecular_function	transferase activity
R	0019005	cellular_component	SCF ubiquitin ligase complex
R	0019788	molecular_function	NEDD8 transferase activity
R	0030174	biological_process	regulation of DNA-templated DNA replication initiation
R	0030510	biological_process	regulation of BMP signaling pathway
R	0030891	cellular_component	VCB complex
R	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R	0031297	biological_process	replication fork processing
R	0031461	cellular_component	cullin-RING ubiquitin ligase complex
R	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
R	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
R	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
R	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
R	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
R	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
R	0031625	molecular_function	ubiquitin protein ligase binding
R	0032006	biological_process	regulation of TOR signaling
R	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
R	0032480	biological_process	negative regulation of type I interferon production
R	0032814	biological_process	regulation of natural killer cell activation
R	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
R	0034599	biological_process	cellular response to oxidative stress
R	0034644	biological_process	cellular response to UV
R	0040029	biological_process	epigenetic regulation of gene expression
R	0042110	biological_process	T cell activation
R	0042127	biological_process	regulation of cell population proliferation
R	0042752	biological_process	regulation of circadian rhythm
R	0042770	biological_process	signal transduction in response to DNA damage
R	0042981	biological_process	regulation of apoptotic process
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043687	biological_process	post-translational protein modification
R	0044314	biological_process	protein K27-linked ubiquitination
R	0044877	molecular_function	protein-containing complex binding
R	0045116	biological_process	protein neddylation
R	0045732	biological_process	positive regulation of protein catabolic process
R	0045995	biological_process	regulation of embryonic development
R	0046627	biological_process	negative regulation of insulin receptor signaling pathway
R	0046872	molecular_function	metal ion binding
R	0050727	biological_process	regulation of inflammatory response
R	0051298	biological_process	centrosome duplication
R	0051726	biological_process	regulation of cell cycle
R	0060090	molecular_function	molecular adaptor activity
R	0060173	biological_process	limb development
R	0060271	biological_process	cilium assembly
R	0060964	biological_process	regulation of miRNA-mediated gene silencing
R	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
R	0061630	molecular_function	ubiquitin protein ligase activity
R	0061663	molecular_function	NEDD8 ligase activity
R	0062197	biological_process	cellular response to chemical stress
R	0070936	biological_process	protein K48-linked ubiquitination
R	0071230	biological_process	cellular response to amino acid stimulus
R	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
R	0080135	biological_process	regulation of cellular response to stress
R	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
R	0090734	cellular_component	site of DNA damage
R	0097602	molecular_function	cullin family protein binding
R	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R	0160240	biological_process	RNA polymerase II transcription initiation surveillance
R	0160276	biological_process	negative regulation of beige fat cell differentiation
R	1900076	biological_process	regulation of cellular response to insulin stimulus
R	1901524	biological_process	regulation of mitophagy
R	1901525	biological_process	negative regulation of mitophagy
R	1901987	biological_process	regulation of cell cycle phase transition
R	1902412	biological_process	regulation of mitotic cytokinesis
R	1902499	biological_process	positive regulation of protein autoubiquitination
R	1902883	biological_process	negative regulation of response to oxidative stress
R	1904178	biological_process	negative regulation of adipose tissue development
R	1904263	biological_process	positive regulation of TORC1 signaling
R	1904415	biological_process	regulation of xenophagy
R	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
R	2000001	biological_process	regulation of DNA damage checkpoint
R	2000036	biological_process	regulation of stem cell population maintenance
R	2000104	biological_process	negative regulation of DNA-templated DNA replication
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0000082	biological_process	G1/S transition of mitotic cell cycle
U	0000122	biological_process	negative regulation of transcription by RNA polymerase II
U	0004842	molecular_function	ubiquitin-protein transferase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005730	cellular_component	nucleolus
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0010498	biological_process	proteasomal protein catabolic process
U	0016567	biological_process	protein ubiquitination
U	0019005	cellular_component	SCF ubiquitin ligase complex
U	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
U	0031461	cellular_component	cullin-RING ubiquitin ligase complex
U	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
U	0031625	molecular_function	ubiquitin protein ligase binding
U	0031981	cellular_component	nuclear lumen
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0072344	biological_process	rescue of stalled ribosome
U	0097193	biological_process	intrinsic apoptotic signaling pathway
U	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
U	0160072	molecular_function	ubiquitin ligase complex scaffold activity
U	0160276	biological_process	negative regulation of beige fat cell differentiation
U	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
U	2000104	biological_process	negative regulation of DNA-templated DNA replication
V	0000082	biological_process	G1/S transition of mitotic cell cycle
V	0000122	biological_process	negative regulation of transcription by RNA polymerase II
V	0000165	biological_process	MAPK cascade
V	0000209	biological_process	protein polyubiquitination
V	0004842	molecular_function	ubiquitin-protein transferase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0005794	cellular_component	Golgi apparatus
V	0005813	cellular_component	centrosome
V	0005829	cellular_component	cytosol
V	0006281	biological_process	DNA repair
V	0006283	biological_process	transcription-coupled nucleotide-excision repair
V	0006289	biological_process	nucleotide-excision repair
V	0006355	biological_process	regulation of DNA-templated transcription
V	0006511	biological_process	ubiquitin-dependent protein catabolic process
V	0006513	biological_process	protein monoubiquitination
V	0006879	biological_process	intracellular iron ion homeostasis
V	0006974	biological_process	DNA damage response
V	0007283	biological_process	spermatogenesis
V	0007346	biological_process	regulation of mitotic cell cycle
V	0008270	molecular_function	zinc ion binding
V	0008283	biological_process	cell population proliferation
V	0010506	biological_process	regulation of autophagy
V	0010564	biological_process	regulation of cell cycle process
V	0010824	biological_process	regulation of centrosome duplication
V	0014033	biological_process	neural crest cell differentiation
V	0016567	biological_process	protein ubiquitination
V	0016740	molecular_function	transferase activity
V	0019005	cellular_component	SCF ubiquitin ligase complex
V	0019788	molecular_function	NEDD8 transferase activity
V	0030174	biological_process	regulation of DNA-templated DNA replication initiation
V	0030510	biological_process	regulation of BMP signaling pathway
V	0030891	cellular_component	VCB complex
V	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
V	0031297	biological_process	replication fork processing
V	0031461	cellular_component	cullin-RING ubiquitin ligase complex
V	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
V	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
V	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
V	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
V	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
V	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
V	0031625	molecular_function	ubiquitin protein ligase binding
V	0032006	biological_process	regulation of TOR signaling
V	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
V	0032480	biological_process	negative regulation of type I interferon production
V	0032814	biological_process	regulation of natural killer cell activation
V	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
V	0034599	biological_process	cellular response to oxidative stress
V	0034644	biological_process	cellular response to UV
V	0040029	biological_process	epigenetic regulation of gene expression
V	0042110	biological_process	T cell activation
V	0042127	biological_process	regulation of cell population proliferation
V	0042752	biological_process	regulation of circadian rhythm
V	0042770	biological_process	signal transduction in response to DNA damage
V	0042981	biological_process	regulation of apoptotic process
V	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
V	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0043687	biological_process	post-translational protein modification
V	0044314	biological_process	protein K27-linked ubiquitination
V	0044877	molecular_function	protein-containing complex binding
V	0045116	biological_process	protein neddylation
V	0045732	biological_process	positive regulation of protein catabolic process
V	0045995	biological_process	regulation of embryonic development
V	0046627	biological_process	negative regulation of insulin receptor signaling pathway
V	0046872	molecular_function	metal ion binding
V	0050727	biological_process	regulation of inflammatory response
V	0051298	biological_process	centrosome duplication
V	0051726	biological_process	regulation of cell cycle
V	0060090	molecular_function	molecular adaptor activity
V	0060173	biological_process	limb development
V	0060271	biological_process	cilium assembly
V	0060964	biological_process	regulation of miRNA-mediated gene silencing
V	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
V	0061630	molecular_function	ubiquitin protein ligase activity
V	0061663	molecular_function	NEDD8 ligase activity
V	0062197	biological_process	cellular response to chemical stress
V	0070936	biological_process	protein K48-linked ubiquitination
V	0071230	biological_process	cellular response to amino acid stimulus
V	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
V	0080135	biological_process	regulation of cellular response to stress
V	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
V	0090734	cellular_component	site of DNA damage
V	0097602	molecular_function	cullin family protein binding
V	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
V	0160240	biological_process	RNA polymerase II transcription initiation surveillance
V	0160276	biological_process	negative regulation of beige fat cell differentiation
V	1900076	biological_process	regulation of cellular response to insulin stimulus
V	1901524	biological_process	regulation of mitophagy
V	1901525	biological_process	negative regulation of mitophagy
V	1901987	biological_process	regulation of cell cycle phase transition
V	1902412	biological_process	regulation of mitotic cytokinesis
V	1902499	biological_process	positive regulation of protein autoubiquitination
V	1902883	biological_process	negative regulation of response to oxidative stress
V	1904178	biological_process	negative regulation of adipose tissue development
V	1904263	biological_process	positive regulation of TORC1 signaling
V	1904415	biological_process	regulation of xenophagy
V	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process
V	2000001	biological_process	regulation of DNA damage checkpoint
V	2000036	biological_process	regulation of stem cell population maintenance
V	2000104	biological_process	negative regulation of DNA-templated DNA replication

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkcIevLIDKqYIeRsqasadeYsYvA

Chain	Residue	Details
E	ILE718-ALA745

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	132
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	132
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	132
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	132
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	136
Details	Repeat: {"description":"TPR 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	132
Details	Repeat: {"description":"TPR 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	136
Details	Repeat: {"description":"TPR 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	132
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	90
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---