Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8JAK

Human MCC in MCCU state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
A	0004075	molecular_function	biotin carboxylase activity
A	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006552	biological_process	L-leucine catabolic process
A	0006768	biological_process	biotin metabolic process
A	0009083	biological_process	branched-chain amino acid catabolic process
A	0009374	molecular_function	biotin binding
A	0016874	molecular_function	ligase activity
A	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
B	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
B	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006552	biological_process	L-leucine catabolic process
B	0009083	biological_process	branched-chain amino acid catabolic process
B	0015936	biological_process	coenzyme A metabolic process
B	0016874	molecular_function	ligase activity
B	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
C	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
C	0004075	molecular_function	biotin carboxylase activity
C	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006552	biological_process	L-leucine catabolic process
C	0006768	biological_process	biotin metabolic process
C	0009083	biological_process	branched-chain amino acid catabolic process
C	0009374	molecular_function	biotin binding
C	0016874	molecular_function	ligase activity
C	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
D	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
D	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006552	biological_process	L-leucine catabolic process
D	0009083	biological_process	branched-chain amino acid catabolic process
D	0015936	biological_process	coenzyme A metabolic process
D	0016874	molecular_function	ligase activity
D	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
E	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
E	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006552	biological_process	L-leucine catabolic process
E	0009083	biological_process	branched-chain amino acid catabolic process
E	0015936	biological_process	coenzyme A metabolic process
E	0016874	molecular_function	ligase activity
E	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
F	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
F	0004075	molecular_function	biotin carboxylase activity
F	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005829	cellular_component	cytosol
F	0006552	biological_process	L-leucine catabolic process
F	0006768	biological_process	biotin metabolic process
F	0009083	biological_process	branched-chain amino acid catabolic process
F	0009374	molecular_function	biotin binding
F	0016874	molecular_function	ligase activity
F	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
G	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
G	0004075	molecular_function	biotin carboxylase activity
G	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005829	cellular_component	cytosol
G	0006552	biological_process	L-leucine catabolic process
G	0006768	biological_process	biotin metabolic process
G	0009083	biological_process	branched-chain amino acid catabolic process
G	0009374	molecular_function	biotin binding
G	0016874	molecular_function	ligase activity
G	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
H	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
H	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005829	cellular_component	cytosol
H	0006552	biological_process	L-leucine catabolic process
H	0009083	biological_process	branched-chain amino acid catabolic process
H	0015936	biological_process	coenzyme A metabolic process
H	0016874	molecular_function	ligase activity
H	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
I	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
I	0004075	molecular_function	biotin carboxylase activity
I	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0005829	cellular_component	cytosol
I	0006552	biological_process	L-leucine catabolic process
I	0006768	biological_process	biotin metabolic process
I	0009083	biological_process	branched-chain amino acid catabolic process
I	0009374	molecular_function	biotin binding
I	0016874	molecular_function	ligase activity
I	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
J	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
J	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0005829	cellular_component	cytosol
J	0006552	biological_process	L-leucine catabolic process
J	0009083	biological_process	branched-chain amino acid catabolic process
J	0015936	biological_process	coenzyme A metabolic process
J	0016874	molecular_function	ligase activity
J	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
K	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
K	0004075	molecular_function	biotin carboxylase activity
K	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005829	cellular_component	cytosol
K	0006552	biological_process	L-leucine catabolic process
K	0006768	biological_process	biotin metabolic process
K	0009083	biological_process	branched-chain amino acid catabolic process
K	0009374	molecular_function	biotin binding
K	0016874	molecular_function	ligase activity
K	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
L	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
L	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0005829	cellular_component	cytosol
L	0006552	biological_process	L-leucine catabolic process
L	0009083	biological_process	branched-chain amino acid catabolic process
L	0015936	biological_process	coenzyme A metabolic process
L	0016874	molecular_function	ligase activity
L	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GDsLmvMiAMKMehtIkS

Chain	Residue	Details
A	GLY671-SER688

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FMEMNTRL

Chain	Residue	Details
A	PHE333-LEU340

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000250\|UniProtKB:P24182

Chain	Residue	Details
A	ARG339
J	LYS495
L	LYS70
L	LYS495
C	ARG339
G	ARG339
F	ARG339
I	ARG339
K	ARG339
H	LYS70
H	LYS495
J	LYS70

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P24182

Chain	Residue	Details
A	LYS163
C	HIS255
C	HIS282
C	GLU322
G	LYS163
G	LYS205
G	GLY211
G	HIS255
G	HIS282
G	GLU322
F	LYS163
A	LYS205
F	LYS205
F	GLY211
F	HIS255
F	HIS282
F	GLU322
I	LYS163
I	LYS205
I	GLY211
I	HIS255
I	HIS282
A	GLY211
I	GLU322
K	LYS163
K	LYS205
K	GLY211
K	HIS255
K	HIS282
K	GLU322
A	HIS255
A	HIS282
A	GLU322
C	LYS163
C	LYS205
C	GLY211

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q99MR8

Chain	Residue	Details
A	LYS237
I	LYS494
K	LYS237
K	LYS494
A	LYS494
C	LYS237
C	LYS494
G	LYS237
G	LYS494
F	LYS237
F	LYS494
I	LYS237

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q99MR8

Chain	Residue	Details
A	LYS581
C	LYS581
G	LYS581
F	LYS581
I	LYS581
K	LYS581

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-biotinyllysine => ECO:0000255\|PROSITE-ProRule:PRU01066

Chain	Residue	Details
A	LYS681
C	LYS681
G	LYS681
F	LYS681
I	LYS681
K	LYS681

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)