8J8L
Overall structure of the LAT1-4F2hc bound with L-dopa
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0002720 | biological_process | positive regulation of cytokine production involved in immune response |
| B | 0003333 | biological_process | amino acid transmembrane transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006865 | biological_process | amino acid transport |
| B | 0009925 | cellular_component | basal plasma membrane |
| B | 0010507 | biological_process | negative regulation of autophagy |
| B | 0010629 | biological_process | negative regulation of gene expression |
| B | 0014850 | biological_process | response to muscle activity |
| B | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| B | 0015173 | molecular_function | aromatic amino acid transmembrane transporter activity |
| B | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| B | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| B | 0015190 | molecular_function | L-leucine transmembrane transporter activity |
| B | 0015196 | molecular_function | L-tryptophan transmembrane transporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015349 | molecular_function | thyroid hormone transmembrane transporter activity |
| B | 0015804 | biological_process | neutral amino acid transport |
| B | 0015807 | biological_process | L-amino acid transport |
| B | 0015818 | biological_process | isoleucine transport |
| B | 0015820 | biological_process | L-leucine transport |
| B | 0015821 | biological_process | methionine transport |
| B | 0015823 | biological_process | phenylalanine transport |
| B | 0015824 | biological_process | proline transport |
| B | 0015827 | biological_process | tryptophan transport |
| B | 0015828 | biological_process | tyrosine transport |
| B | 0015829 | biological_process | valine transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0031528 | cellular_component | microvillus membrane |
| B | 0032328 | biological_process | alanine transport |
| B | 0032729 | biological_process | positive regulation of type II interferon production |
| B | 0032740 | biological_process | positive regulation of interleukin-17 production |
| B | 0032753 | biological_process | positive regulation of interleukin-4 production |
| B | 0042149 | biological_process | cellular response to glucose starvation |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042908 | biological_process | xenobiotic transport |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0055093 | biological_process | response to hyperoxia |
| B | 0060252 | biological_process | positive regulation of glial cell proliferation |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070327 | biological_process | thyroid hormone transport |
| B | 0071222 | biological_process | cellular response to lipopolysaccharide |
| B | 0071230 | biological_process | cellular response to amino acid stimulus |
| B | 0089718 | biological_process | amino acid import across plasma membrane |
| B | 0097421 | biological_process | liver regeneration |
| B | 0098591 | cellular_component | external side of apical plasma membrane |
| B | 0150104 | biological_process | transport across blood-brain barrier |
| B | 1902024 | biological_process | L-histidine transport |
| B | 1902475 | biological_process | L-alpha-amino acid transmembrane transport |
| B | 1903577 | biological_process | cellular response to L-arginine |
| B | 1903801 | biological_process | L-leucine import across plasma membrane |
| B | 1904556 | biological_process | L-tryptophan transmembrane transport |
| B | 1905460 | biological_process | negative regulation of vascular associated smooth muscle cell apoptotic process |
| B | 1905534 | biological_process | positive regulation of L-leucine import across plasma membrane |
| B | 1990184 | cellular_component | amino acid transport complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 241 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30867591 |
| Chain | Residue | Details |
| B | ILE50-VAL70 | |
| B | VAL396-ILE416 | |
| B | VAL431-PHE451 | |
| B | CYS458-TRP478 | |
| B | LEU84-ALA104 | |
| B | LEU127-ILE147 | |
| B | ALA170-VAL190 | |
| B | ALA193-LEU214 | |
| B | ILE243-VAL263 | |
| B | ALA277-PHE297 | |
| B | TRP325-THR345 | |
| B | LEU370-SER390 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 95 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| B | THR71-GLY83 | |
| B | VAL148-GLU169 | |
| B | GLY215-ASN242 | |
| B | THR298-SER324 | |
| B | LYS391-SER395 | |
| B | TRP452-GLU457 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 98 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | GLU105-SER126 | |
| B | LYS191-ALA192 | |
| B | THR264-LEU276 | |
| B | SER346-GLN369 | |
| B | TRP417-LYS430 | |
| B | LYS479-THR507 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER31 | |
| A | SER135 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | SER35 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| B | THR45 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| B | LYS19 | |
| A | SER409 | |
| B | LYS30 | |
| A | SER528 | |
| A | SER532 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | ASN366 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | ASN382 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | ASN425 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMH, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V |
| Chain | Residue | Details |
| A | ASN507 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| A | LYS148 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| A | LYS167 |
