8J8I
Membrane-bound structure of CD3z cytoplasmic domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0033001 | cellular_component | Fc-gamma receptor III complex |
| A | 0038094 | biological_process | Fc-gamma receptor signaling pathway |
| A | 0042101 | cellular_component | T cell receptor complex |
| A | 0042105 | cellular_component | alpha-beta T cell receptor complex |
| A | 0042106 | cellular_component | gamma-delta T cell receptor complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046629 | biological_process | gamma-delta T cell activation |
| A | 0046631 | biological_process | alpha-beta T cell activation |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0050852 | biological_process | T cell receptor signaling pathway |
| A | 0051259 | biological_process | protein complex oligomerization |
| A | 0065003 | biological_process | protein-containing complex assembly |
| A | 0098797 | cellular_component | plasma membrane protein complex |
| A | 1990782 | molecular_function | protein tyrosine kinase binding |
| A | 2000010 | biological_process | positive regulation of protein localization to cell surface |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU7-LEU27 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 112 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG28-ARG140 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:15144186 |
| Chain | Residue | Details |
| A | SER34 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15144186, ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | TYR40 | |
| A | TYR48 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:12522270 |
| Chain | Residue | Details |
| A | TYR59 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:12522270, ECO:0007744|PubMed:15144186, ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | TYR87 | |
| A | TYR118 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | TYR99 | |
| A | TYR129 |
