8J6H

Structure and allosteric regulation of the inosine 5'-monophosphate-specific phosphatase ISN1 from Saccharomyces cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005524	molecular_function	ATP binding
A	0005575	cellular_component	cellular_component
A	0006190	biological_process	inosine salvage
A	0008253	molecular_function	5'-nucleotidase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0071590	biological_process	nicotinamide riboside biosynthetic process
A	0071592	biological_process	nicotinic acid riboside biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0005524	molecular_function	ATP binding
B	0005575	cellular_component	cellular_component
B	0006190	biological_process	inosine salvage
B	0008253	molecular_function	5'-nucleotidase activity
B	0009117	biological_process	nucleotide metabolic process
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0071590	biological_process	nicotinamide riboside biosynthetic process
B	0071592	biological_process	nicotinic acid riboside biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0005524	molecular_function	ATP binding
C	0005575	cellular_component	cellular_component
C	0006190	biological_process	inosine salvage
C	0008253	molecular_function	5'-nucleotidase activity
C	0009117	biological_process	nucleotide metabolic process
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0071590	biological_process	nicotinamide riboside biosynthetic process
C	0071592	biological_process	nicotinic acid riboside biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0005524	molecular_function	ATP binding
D	0005575	cellular_component	cellular_component
D	0006190	biological_process	inosine salvage
D	0008253	molecular_function	5'-nucleotidase activity
D	0009117	biological_process	nucleotide metabolic process
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0071590	biological_process	nicotinamide riboside biosynthetic process
D	0071592	biological_process	nicotinic acid riboside biosynthetic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:A0A144A134

Chain	Residue	Details
A	ASP172
B	ASP172
C	ASP172
D	ASP172

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:A0A144A134

Chain	Residue	Details
A	ASP174
B	ASP174
C	ASP174
D	ASP174

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site_id	SWS_FT_FI3
Number of Residues	32
Details	BINDING: BINDING => ECO:0000250|UniProtKB:A0A144A134

Chain	Residue	Details
A	HIS144
B	ASP172
B	ASP174
B	ASP180
B	THR208
B	ASP376
B	LYS384
B	ASP411
C	HIS144
C	ASP172
C	ASP174
A	ASP172
C	ASP180
C	THR208
C	ASP376
C	LYS384
C	ASP411
D	HIS144
D	ASP172
D	ASP174
D	ASP180
D	THR208
A	ASP174
D	ASP376
D	LYS384
D	ASP411
A	ASP180
A	THR208
A	ASP376
A	LYS384
A	ASP411
B	HIS144

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