Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8J4Z

Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
A	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006552	biological_process	L-leucine catabolic process
A	0009083	biological_process	branched-chain amino acid catabolic process
A	0015936	biological_process	coenzyme A metabolic process
A	0016874	molecular_function	ligase activity
A	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
B	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
B	0004075	molecular_function	biotin carboxylase activity
B	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006552	biological_process	L-leucine catabolic process
B	0006768	biological_process	biotin metabolic process
B	0009083	biological_process	branched-chain amino acid catabolic process
B	0009374	molecular_function	biotin binding
B	0016874	molecular_function	ligase activity
B	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
C	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
C	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006552	biological_process	L-leucine catabolic process
C	0009083	biological_process	branched-chain amino acid catabolic process
C	0015936	biological_process	coenzyme A metabolic process
C	0016874	molecular_function	ligase activity
C	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
D	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
D	0004075	molecular_function	biotin carboxylase activity
D	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006552	biological_process	L-leucine catabolic process
D	0006768	biological_process	biotin metabolic process
D	0009083	biological_process	branched-chain amino acid catabolic process
D	0009374	molecular_function	biotin binding
D	0016874	molecular_function	ligase activity
D	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
E	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
E	0004075	molecular_function	biotin carboxylase activity
E	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006552	biological_process	L-leucine catabolic process
E	0006768	biological_process	biotin metabolic process
E	0009083	biological_process	branched-chain amino acid catabolic process
E	0009374	molecular_function	biotin binding
E	0016874	molecular_function	ligase activity
E	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
F	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
F	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005829	cellular_component	cytosol
F	0006552	biological_process	L-leucine catabolic process
F	0009083	biological_process	branched-chain amino acid catabolic process
F	0015936	biological_process	coenzyme A metabolic process
F	0016874	molecular_function	ligase activity
F	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
G	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
G	0004075	molecular_function	biotin carboxylase activity
G	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005829	cellular_component	cytosol
G	0006552	biological_process	L-leucine catabolic process
G	0006768	biological_process	biotin metabolic process
G	0009083	biological_process	branched-chain amino acid catabolic process
G	0009374	molecular_function	biotin binding
G	0016874	molecular_function	ligase activity
G	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
H	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
H	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005829	cellular_component	cytosol
H	0006552	biological_process	L-leucine catabolic process
H	0009083	biological_process	branched-chain amino acid catabolic process
H	0015936	biological_process	coenzyme A metabolic process
H	0016874	molecular_function	ligase activity
H	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
I	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
I	0004075	molecular_function	biotin carboxylase activity
I	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0005829	cellular_component	cytosol
I	0006552	biological_process	L-leucine catabolic process
I	0006768	biological_process	biotin metabolic process
I	0009083	biological_process	branched-chain amino acid catabolic process
I	0009374	molecular_function	biotin binding
I	0016874	molecular_function	ligase activity
I	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
J	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
J	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0005829	cellular_component	cytosol
J	0006552	biological_process	L-leucine catabolic process
J	0009083	biological_process	branched-chain amino acid catabolic process
J	0015936	biological_process	coenzyme A metabolic process
J	0016874	molecular_function	ligase activity
J	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
K	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
K	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005829	cellular_component	cytosol
K	0006552	biological_process	L-leucine catabolic process
K	0009083	biological_process	branched-chain amino acid catabolic process
K	0015936	biological_process	coenzyme A metabolic process
K	0016874	molecular_function	ligase activity
K	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex
L	0002169	cellular_component	3-methylcrotonyl-CoA carboxylase complex, mitochondrial
L	0004075	molecular_function	biotin carboxylase activity
L	0004485	molecular_function	methylcrotonoyl-CoA carboxylase activity
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0005829	cellular_component	cytosol
L	0006552	biological_process	L-leucine catabolic process
L	0006768	biological_process	biotin metabolic process
L	0009083	biological_process	branched-chain amino acid catabolic process
L	0009374	molecular_function	biotin binding
L	0016874	molecular_function	ligase activity
L	1905202	cellular_component	methylcrotonoyl-CoA carboxylase complex

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GDsLmvMiAMKMehtIkS

Chain	Residue	Details
E	GLY671-SER688

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FMEMNTRL

Chain	Residue	Details
E	PHE333-LEU340

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: ACT_SITE => ECO:0000250\|UniProtKB:P24182

Chain	Residue	Details
E	ARG339
H	LYS495
K	LYS70
K	LYS495
B	ARG339
D	ARG339
G	ARG339
I	ARG339
L	ARG339
F	LYS70
F	LYS495
H	LYS70

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P24182

Chain	Residue	Details
E	LYS163
B	HIS255
B	HIS282
B	GLU322
D	LYS163
D	LYS205
D	GLY211
D	HIS255
D	HIS282
D	GLU322
G	LYS163
E	LYS205
G	LYS205
G	GLY211
G	HIS255
G	HIS282
G	GLU322
I	LYS163
I	LYS205
I	GLY211
I	HIS255
I	HIS282
E	GLY211
I	GLU322
L	LYS163
L	LYS205
L	GLY211
L	HIS255
L	HIS282
L	GLU322
E	HIS255
E	HIS282
E	GLU322
B	LYS163
B	LYS205
B	GLY211

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q99MR8

Chain	Residue	Details
E	LYS237
I	LYS494
L	LYS237
L	LYS494
E	LYS494
B	LYS237
B	LYS494
D	LYS237
D	LYS494
G	LYS237
G	LYS494
I	LYS237

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:Q99MR8

Chain	Residue	Details
E	LYS581
B	LYS581
D	LYS581
G	LYS581
I	LYS581
L	LYS581

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: N6-biotinyllysine => ECO:0000255\|PROSITE-ProRule:PRU01066

Chain	Residue	Details
E	LYS681
B	LYS681
D	LYS681
G	LYS681
I	LYS681
L	LYS681

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)