8J2F

Human neutral shpingomyelinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004767	molecular_function	sphingomyelin phosphodiesterase activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0005901	cellular_component	caveola
A	0006629	biological_process	lipid metabolic process
A	0006665	biological_process	sphingolipid metabolic process
A	0006672	biological_process	ceramide metabolic process
A	0006684	biological_process	sphingomyelin metabolic process
A	0006685	biological_process	sphingomyelin catabolic process
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0009612	biological_process	response to mechanical stimulus
A	0016787	molecular_function	hydrolase activity
A	0030149	biological_process	sphingolipid catabolic process
A	0035556	biological_process	intracellular signal transduction
A	0046513	biological_process	ceramide biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0071944	cellular_component	cell periphery
B	0003824	molecular_function	catalytic activity
B	0004767	molecular_function	sphingomyelin phosphodiesterase activity
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005886	cellular_component	plasma membrane
B	0005901	cellular_component	caveola
B	0006629	biological_process	lipid metabolic process
B	0006665	biological_process	sphingolipid metabolic process
B	0006672	biological_process	ceramide metabolic process
B	0006684	biological_process	sphingomyelin metabolic process
B	0006685	biological_process	sphingomyelin catabolic process
B	0008081	molecular_function	phosphoric diester hydrolase activity
B	0009612	biological_process	response to mechanical stimulus
B	0016787	molecular_function	hydrolase activity
B	0030149	biological_process	sphingolipid catabolic process
B	0035556	biological_process	intracellular signal transduction
B	0046513	biological_process	ceramide biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0071944	cellular_component	cell periphery

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Important for substrate recognition","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---