8J1V
Cryo-EM structure of SARS-CoV2 Omicron BA.5 spike in complex with 8-9D Fabs
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| A | 0019031 | cellular_component | viral envelope |
| A | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| A | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| A | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| A | 0055036 | cellular_component | virion membrane |
| A | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| B | 0016020 | cellular_component | membrane |
| B | 0019031 | cellular_component | viral envelope |
| B | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| B | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| B | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| B | 0055036 | cellular_component | virion membrane |
| B | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
| E | 0016020 | cellular_component | membrane |
| E | 0019031 | cellular_component | viral envelope |
| E | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| E | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| E | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| E | 0055036 | cellular_component | virion membrane |
| E | 0075509 | biological_process | endocytosis involved in viral entry into host cell |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| A | VAL687 | |
| B | VAL687 | |
| E | VAL687 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616 |
| Chain | Residue | Details |
| A | PRO817 | |
| B | PRO817 | |
| E | PRO817 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | ASN63 | |
| B | THR1076 | |
| E | ASN63 | |
| E | THR124 | |
| E | THR719 | |
| E | SER803 | |
| E | THR1076 | |
| A | THR124 | |
| A | THR719 | |
| A | SER803 | |
| A | THR1076 | |
| B | ASN63 | |
| B | THR124 | |
| B | THR719 | |
| B | SER803 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | THR76 | |
| A | SER151 | |
| B | THR76 | |
| B | SER151 | |
| E | THR76 | |
| E | SER151 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | THR167 | |
| B | THR333 | |
| B | THR345 | |
| B | THR618 | |
| B | SER659 | |
| B | THR1100 | |
| E | THR167 | |
| E | THR284 | |
| E | THR333 | |
| E | THR345 | |
| E | THR618 | |
| A | THR284 | |
| E | SER659 | |
| E | THR1100 | |
| A | THR333 | |
| A | THR345 | |
| A | THR618 | |
| A | SER659 | |
| A | THR1100 | |
| B | THR167 | |
| B | THR284 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | THR236 | |
| A | SER711 | |
| B | THR236 | |
| B | SER711 | |
| E | THR236 | |
| E | SER711 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| A | SER325 | |
| B | SER325 | |
| E | SER325 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391 |
| Chain | Residue | Details |
| A | VAL327 | |
| B | VAL327 | |
| E | VAL327 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | SER605 | |
| B | SER605 | |
| E | SER605 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583 |
| Chain | Residue | Details |
| A | THR678 | |
| A | SER680 | |
| B | THR678 | |
| B | SER680 | |
| E | THR678 | |
| E | SER680 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942 |
| Chain | Residue | Details |
| A | THR1136 | |
| B | THR1136 | |
| E | THR1136 |
