8J1R

cryo-EM structures of Ufd4 in complex with Ubc4-Ub

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010994	biological_process	free ubiquitin chain polymerization
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0035519	biological_process	protein K29-linked ubiquitination
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0061630	molecular_function	ubiquitin protein ligase activity
A	1904855	molecular_function	proteasome regulatory particle binding
C	0000166	molecular_function	nucleotide binding
C	0000209	biological_process	protein polyubiquitination
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0016567	biological_process	protein ubiquitination
C	0016740	molecular_function	transferase activity
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0034605	biological_process	cellular response to heat
C	0043130	molecular_function	ubiquitin binding
C	0043162	biological_process	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
C	0061631	molecular_function	ubiquitin conjugating enzyme activity
C	0070628	molecular_function	proteasome binding
C	0071629	biological_process	cytoplasm protein quality control by the ubiquitin-proteasome system
C	0072344	biological_process	rescue of stalled ribosome
C	0072671	biological_process	mitochondria-associated ubiquitin-dependent protein catabolic process
C	1990116	biological_process	ribosome-associated ubiquitin-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00183
Number of Residues	16
Details	UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInan.GnICLdiL

Chain	Residue	Details
C	TYR75-LEU90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	74
Details	Region: {"description":"K-box"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00104","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	21
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	11
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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