8J0T

Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in the apo-form

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005886	cellular_component	plasma membrane
1	0015078	molecular_function	proton transmembrane transporter activity
1	0015986	biological_process	proton motive force-driven ATP synthesis
1	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
1	0045259	cellular_component	proton-transporting ATP synthase complex
1	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
1	1902600	biological_process	proton transmembrane transport
2	0005886	cellular_component	plasma membrane
2	0015078	molecular_function	proton transmembrane transporter activity
2	0015986	biological_process	proton motive force-driven ATP synthesis
2	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
2	0045259	cellular_component	proton-transporting ATP synthase complex
2	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
2	1902600	biological_process	proton transmembrane transport
3	0005886	cellular_component	plasma membrane
3	0015078	molecular_function	proton transmembrane transporter activity
3	0015986	biological_process	proton motive force-driven ATP synthesis
3	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
3	0045259	cellular_component	proton-transporting ATP synthase complex
3	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
3	1902600	biological_process	proton transmembrane transport
4	0005886	cellular_component	plasma membrane
4	0015078	molecular_function	proton transmembrane transporter activity
4	0015986	biological_process	proton motive force-driven ATP synthesis
4	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
4	0045259	cellular_component	proton-transporting ATP synthase complex
4	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
4	1902600	biological_process	proton transmembrane transport
5	0005886	cellular_component	plasma membrane
5	0015078	molecular_function	proton transmembrane transporter activity
5	0015986	biological_process	proton motive force-driven ATP synthesis
5	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
5	0045259	cellular_component	proton-transporting ATP synthase complex
5	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
5	1902600	biological_process	proton transmembrane transport
6	0005886	cellular_component	plasma membrane
6	0015078	molecular_function	proton transmembrane transporter activity
6	0015986	biological_process	proton motive force-driven ATP synthesis
6	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
6	0045259	cellular_component	proton-transporting ATP synthase complex
6	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
6	1902600	biological_process	proton transmembrane transport
7	0005886	cellular_component	plasma membrane
7	0015078	molecular_function	proton transmembrane transporter activity
7	0015986	biological_process	proton motive force-driven ATP synthesis
7	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
7	0045259	cellular_component	proton-transporting ATP synthase complex
7	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
7	1902600	biological_process	proton transmembrane transport
8	0005886	cellular_component	plasma membrane
8	0015078	molecular_function	proton transmembrane transporter activity
8	0015986	biological_process	proton motive force-driven ATP synthesis
8	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
8	0045259	cellular_component	proton-transporting ATP synthase complex
8	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
8	1902600	biological_process	proton transmembrane transport
9	0005886	cellular_component	plasma membrane
9	0015078	molecular_function	proton transmembrane transporter activity
9	0015986	biological_process	proton motive force-driven ATP synthesis
9	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
9	0045259	cellular_component	proton-transporting ATP synthase complex
9	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
9	1902600	biological_process	proton transmembrane transport
a	0005886	cellular_component	plasma membrane
a	0015078	molecular_function	proton transmembrane transporter activity
a	0015986	biological_process	proton motive force-driven ATP synthesis
a	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
a	0045259	cellular_component	proton-transporting ATP synthase complex
a	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
a	1902600	biological_process	proton transmembrane transport
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
b	0005886	cellular_component	plasma membrane
b	0015078	molecular_function	proton transmembrane transporter activity
b	0015986	biological_process	proton motive force-driven ATP synthesis
b	0045259	cellular_component	proton-transporting ATP synthase complex
b	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	1902600	biological_process	proton transmembrane transport
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0043531	molecular_function	ADP binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
d	0005886	cellular_component	plasma membrane
d	0015078	molecular_function	proton transmembrane transporter activity
d	0015986	biological_process	proton motive force-driven ATP synthesis
d	0045259	cellular_component	proton-transporting ATP synthase complex
d	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
d	1902600	biological_process	proton transmembrane transport
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005886	cellular_component	plasma membrane
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005524	molecular_function	ATP binding
E	0005576	cellular_component	extracellular region
E	0005886	cellular_component	plasma membrane
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005886	cellular_component	plasma membrane
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
G	0045259	cellular_component	proton-transporting ATP synthase complex
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0045259	cellular_component	proton-transporting ATP synthase complex
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLASSS

Chain	Residue	Details
D	PRO355-SER364
A	PRO366-SER375

---

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITqEisEivgGAnA

Chain	Residue	Details
G	ILE287-ALA300

---

site_id	PS00449
Number of Residues	10
Details	ATPASE_A ATP synthase a subunit signature. SLSLRLFGNI

Chain	Residue	Details
a	SER182-ILE191

---

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. ARQPeaqgrLfTpfFItvgLvE

Chain	Residue	Details
1	ALA40-GLU61

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"Required for activity"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Cross-link: {"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)","evidences":[{"source":"PubMed","id":"20066036","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01347","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	9
Details	Site: {"description":"Reversibly protonated during proton transport","evidences":[{"source":"HAMAP-Rule","id":"MF_01396","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	360
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01396","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	100
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01398","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	20
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	167
Details	Region: {"description":"ATP synthase subunit b"}

Chain

Residue

Details

---