8J0N

cryo-EM structure of human EMC

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0016020	cellular_component	membrane
B	0032977	molecular_function	membrane insertase activity
B	0042406	cellular_component	extrinsic component of endoplasmic reticulum membrane
B	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
B	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
B	0072546	cellular_component	EMC complex
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0016020	cellular_component	membrane
C	0032977	molecular_function	membrane insertase activity
C	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
C	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
C	0072546	cellular_component	EMC complex
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006915	biological_process	apoptotic process
D	0016020	cellular_component	membrane
D	0032977	molecular_function	membrane insertase activity
D	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
D	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
D	0072546	cellular_component	EMC complex
E	0000139	cellular_component	Golgi membrane
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005768	cellular_component	endosome
E	0005769	cellular_component	early endosome
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0005886	cellular_component	plasma membrane
E	0006812	biological_process	monoatomic cation transport
E	0006824	biological_process	cobalt ion transport
E	0006825	biological_process	copper ion transport
E	0006826	biological_process	iron ion transport
E	0015087	molecular_function	cobalt ion transmembrane transporter activity
E	0015093	molecular_function	ferrous iron transmembrane transporter activity
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0015693	biological_process	magnesium ion transport
E	0016020	cellular_component	membrane
E	0022890	molecular_function	inorganic cation transmembrane transporter activity
E	0031901	cellular_component	early endosome membrane
E	0032977	molecular_function	membrane insertase activity
E	0034755	biological_process	iron ion transmembrane transport
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
E	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
E	0072546	cellular_component	EMC complex
E	1903830	biological_process	magnesium ion transmembrane transport
F	0000045	biological_process	autophagosome assembly
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0016020	cellular_component	membrane
F	0032977	molecular_function	membrane insertase activity
F	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
F	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
F	0072546	cellular_component	EMC complex
F	1903349	cellular_component	omegasome membrane
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005794	cellular_component	Golgi apparatus
H	0016020	cellular_component	membrane
H	0032977	molecular_function	membrane insertase activity
H	0045050	biological_process	protein insertion into ER membrane by stop-transfer membrane-anchor sequence
H	0071816	biological_process	tail-anchored membrane protein insertion into ER membrane
H	0072546	cellular_component	EMC complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:32439656

Chain	Residue	Details
J	ASN182
F	ARG72-LEU89

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site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
G	PHE160-PRO180
F	GLY51-GLY71
F	ILE90-MET106

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site_id	SWS_FT_FI3
Number of Residues	61
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:32439656

Chain	Residue	Details
G	LYS181-ARG242
F	VAL107-TYR110

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
F	ALA2
A	ASN818

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
D	SER36

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