Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8IXF

GMPCPP-Alpha4A/Beta2A-microtubule decorated with kinesin non-seam region

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0003777	molecular_function	microtubule motor activity
a	0005524	molecular_function	ATP binding
a	0007018	biological_process	microtubule-based movement
a	0008017	molecular_function	microtubule binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0016787	molecular_function	hydrolase activity
A	0019899	molecular_function	enzyme binding
A	0046872	molecular_function	metal ion binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0016787	molecular_function	hydrolase activity
B	0019899	molecular_function	enzyme binding
B	0046872	molecular_function	metal ion binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
C	0016787	molecular_function	hydrolase activity
C	0019899	molecular_function	enzyme binding
C	0046872	molecular_function	metal ion binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0016787	molecular_function	hydrolase activity
D	0019899	molecular_function	enzyme binding
D	0046872	molecular_function	metal ion binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0007017	biological_process	microtubule-based process
E	0016787	molecular_function	hydrolase activity
E	0019899	molecular_function	enzyme binding
E	0046872	molecular_function	metal ion binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007017	biological_process	microtubule-based process
F	0016787	molecular_function	hydrolase activity
F	0019899	molecular_function	enzyme binding
F	0046872	molecular_function	metal ion binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0007017	biological_process	microtubule-based process
G	0016787	molecular_function	hydrolase activity
G	0019899	molecular_function	enzyme binding
G	0046872	molecular_function	metal ion binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0007017	biological_process	microtubule-based process
H	0016787	molecular_function	hydrolase activity
H	0019899	molecular_function	enzyme binding
H	0046872	molecular_function	metal ion binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0007017	biological_process	microtubule-based process
I	0016787	molecular_function	hydrolase activity
I	0019899	molecular_function	enzyme binding
I	0046872	molecular_function	metal ion binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0003924	molecular_function	GTPase activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0007017	biological_process	microtubule-based process
J	0015630	cellular_component	microtubule cytoskeleton
J	0021987	biological_process	cerebral cortex development
J	0045171	cellular_component	intercellular bridge
J	0046872	molecular_function	metal ion binding
J	0072686	cellular_component	mitotic spindle
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0003924	molecular_function	GTPase activity
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0007017	biological_process	microtubule-based process
K	0015630	cellular_component	microtubule cytoskeleton
K	0021987	biological_process	cerebral cortex development
K	0045171	cellular_component	intercellular bridge
K	0046872	molecular_function	metal ion binding
K	0072686	cellular_component	mitotic spindle
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0003924	molecular_function	GTPase activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0007017	biological_process	microtubule-based process
L	0015630	cellular_component	microtubule cytoskeleton
L	0021987	biological_process	cerebral cortex development
L	0045171	cellular_component	intercellular bridge
L	0046872	molecular_function	metal ion binding
L	0072686	cellular_component	mitotic spindle
M	0000226	biological_process	microtubule cytoskeleton organization
M	0000278	biological_process	mitotic cell cycle
M	0003924	molecular_function	GTPase activity
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005874	cellular_component	microtubule
M	0007017	biological_process	microtubule-based process
M	0015630	cellular_component	microtubule cytoskeleton
M	0021987	biological_process	cerebral cortex development
M	0045171	cellular_component	intercellular bridge
M	0046872	molecular_function	metal ion binding
M	0072686	cellular_component	mitotic spindle
N	0000226	biological_process	microtubule cytoskeleton organization
N	0000278	biological_process	mitotic cell cycle
N	0003924	molecular_function	GTPase activity
N	0005200	molecular_function	structural constituent of cytoskeleton
N	0005525	molecular_function	GTP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005874	cellular_component	microtubule
N	0007017	biological_process	microtubule-based process
N	0015630	cellular_component	microtubule cytoskeleton
N	0021987	biological_process	cerebral cortex development
N	0045171	cellular_component	intercellular bridge
N	0046872	molecular_function	metal ion binding
N	0072686	cellular_component	mitotic spindle
O	0000226	biological_process	microtubule cytoskeleton organization
O	0000278	biological_process	mitotic cell cycle
O	0003924	molecular_function	GTPase activity
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005525	molecular_function	GTP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005874	cellular_component	microtubule
O	0007017	biological_process	microtubule-based process
O	0015630	cellular_component	microtubule cytoskeleton
O	0021987	biological_process	cerebral cortex development
O	0045171	cellular_component	intercellular bridge
O	0046872	molecular_function	metal ion binding
O	0072686	cellular_component	mitotic spindle
P	0000226	biological_process	microtubule cytoskeleton organization
P	0000278	biological_process	mitotic cell cycle
P	0003924	molecular_function	GTPase activity
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005525	molecular_function	GTP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005874	cellular_component	microtubule
P	0007017	biological_process	microtubule-based process
P	0015630	cellular_component	microtubule cytoskeleton
P	0021987	biological_process	cerebral cortex development
P	0045171	cellular_component	intercellular bridge
P	0046872	molecular_function	metal ion binding
P	0072686	cellular_component	mitotic spindle
Q	0000226	biological_process	microtubule cytoskeleton organization
Q	0000278	biological_process	mitotic cell cycle
Q	0003924	molecular_function	GTPase activity
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0007017	biological_process	microtubule-based process
Q	0015630	cellular_component	microtubule cytoskeleton
Q	0021987	biological_process	cerebral cortex development
Q	0045171	cellular_component	intercellular bridge
Q	0046872	molecular_function	metal ion binding
Q	0072686	cellular_component	mitotic spindle
R	0000226	biological_process	microtubule cytoskeleton organization
R	0000278	biological_process	mitotic cell cycle
R	0003924	molecular_function	GTPase activity
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005874	cellular_component	microtubule
R	0007017	biological_process	microtubule-based process
R	0015630	cellular_component	microtubule cytoskeleton
R	0021987	biological_process	cerebral cortex development
R	0045171	cellular_component	intercellular bridge
R	0046872	molecular_function	metal ion binding
R	0072686	cellular_component	mitotic spindle
S	0003777	molecular_function	microtubule motor activity
S	0005524	molecular_function	ATP binding
S	0007018	biological_process	microtubule-based movement
S	0008017	molecular_function	microtubule binding
T	0003777	molecular_function	microtubule motor activity
T	0005524	molecular_function	ATP binding
T	0007018	biological_process	microtubule-based movement
T	0008017	molecular_function	microtubule binding
U	0003777	molecular_function	microtubule motor activity
U	0005524	molecular_function	ATP binding
U	0007018	biological_process	microtubule-based movement
U	0008017	molecular_function	microtubule binding
V	0003777	molecular_function	microtubule motor activity
V	0005524	molecular_function	ATP binding
V	0007018	biological_process	microtubule-based movement
V	0008017	molecular_function	microtubule binding
W	0003777	molecular_function	microtubule motor activity
W	0005524	molecular_function	ATP binding
W	0007018	biological_process	microtubule-based movement
W	0008017	molecular_function	microtubule binding
X	0003777	molecular_function	microtubule motor activity
X	0005524	molecular_function	ATP binding
X	0007018	biological_process	microtubule-based movement
X	0008017	molecular_function	microtubule binding
Y	0003777	molecular_function	microtubule motor activity
Y	0005524	molecular_function	ATP binding
Y	0007018	biological_process	microtubule-based movement
Y	0008017	molecular_function	microtubule binding
Z	0003777	molecular_function	microtubule motor activity
Z	0005524	molecular_function	ATP binding
Z	0007018	biological_process	microtubule-based movement
Z	0008017	molecular_function	microtubule binding

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
Q	GLY140-GLY146
I	GLY148-GLY154

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
Q	MET1-ILE4

site_id	PS00356
Number of Residues	19
Details	HTH_LACI_1 LacI-type HTH domain signature. LvDLAgsAkVSktGAegAV

Chain	Residue	Details
a	LEU229-VAL247

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING:

Chain	Residue	Details
Y	GLY85
J	GLY142
J	THR143
J	GLY144
J	ASN204
J	ASN226
K	GLN11
K	SER138
K	GLY142
K	THR143
K	GLY144
S	GLY85
K	ASN204
K	ASN226
L	GLN11
L	SER138
L	GLY142
L	THR143
L	GLY144
L	ASN204
L	ASN226
M	GLN11
T	GLY85
M	SER138
M	GLY142
M	THR143
M	GLY144
M	ASN204
M	ASN226
N	GLN11
N	SER138
N	GLY142
N	THR143
U	GLY85
N	GLY144
N	ASN204
N	ASN226
O	GLN11
O	SER138
O	GLY142
O	THR143
O	GLY144
O	ASN204
O	ASN226
V	GLY85
P	GLN11
P	SER138
P	GLY142
P	THR143
P	GLY144
P	ASN204
P	ASN226
R	GLN11
R	SER138
R	GLY142
W	GLY85
R	THR143
R	GLY144
R	ASN204
R	ASN226
X	GLY85
Z	GLY85
a	GLY85

site_id	SWS_FT_FI2
Number of Residues	9
Details	MOD_RES: N-acetylalanine => ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22223895, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
Y	ALA2
A	GLU77
A	SER146
A	GLY150
A	THR151
A	THR185
A	ASN212
A	ASN234
B	GLN11
B	GLU77
B	SER146
S	ALA2
B	GLY150
B	THR151
B	THR185
B	ASN212
B	ASN234
C	GLN11
C	GLU77
C	SER146
C	GLY150
C	THR151
T	ALA2
C	THR185
C	ASN212
C	ASN234
D	GLN11
D	GLU77
D	SER146
D	GLY150
D	THR151
D	THR185
D	ASN212
U	ALA2
D	ASN234
E	GLN11
E	GLU77
E	SER146
E	GLY150
E	THR151
E	THR185
E	ASN212
E	ASN234
F	GLN11
V	ALA2
F	GLU77
F	SER146
F	GLY150
F	THR151
F	THR185
F	ASN212
F	ASN234
G	GLN11
G	GLU77
G	SER146
W	ALA2
G	GLY150
G	THR151
G	THR185
G	ASN212
G	ASN234
H	GLN11
H	GLU77
H	SER146
H	GLY150
H	THR151
X	ALA2
H	THR185
H	ASN212
H	ASN234
Z	ALA2
a	ALA2

site_id	SWS_FT_FI3
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
Y	LYS213
W	LYS213
X	LYS213
Z	LYS213
a	LYS213
J	SER40
S	LYS213
L	SER40
T	LYS213
N	SER40
U	LYS213
P	SER40
V	LYS213

site_id	SWS_FT_FI4
Number of Residues	9
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P99024

Chain	Residue	Details
Q	LYS58
J	LYS58
K	LYS58
L	LYS58
M	LYS58
N	LYS58
O	LYS58
P	LYS58
R	LYS58

site_id	SWS_FT_FI5
Number of Residues	9
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000250\|UniProtKB:Q13885

Chain	Residue	Details
Q	SER172
J	SER172
K	SER172
L	SER172
M	SER172
N	SER172
O	SER172
P	SER172
R	SER172

site_id	SWS_FT_FI6
Number of Residues	18
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
Q	THR285
M	THR290
N	THR285
N	THR290
O	THR285
O	THR290
P	THR285
P	THR290
R	THR285
R	THR290
Q	THR290
J	THR285
J	THR290
K	THR285
K	THR290
L	THR285
L	THR290
M	THR285

site_id	SWS_FT_FI7
Number of Residues	9
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
Q	ARG318
J	ARG318
K	ARG318
L	ARG318
M	ARG318
N	ARG318
O	ARG318
P	ARG318
R	ARG318

site_id	SWS_FT_FI8
Number of Residues	9
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250\|UniProtKB:Q2T9S0

Chain	Residue	Details
Q	GLU438
J	GLU438
K	GLU438
L	GLU438
M	GLU438
N	GLU438
O	GLU438
P	GLU438
R	GLU438

site_id	SWS_FT_FI9
Number of Residues	9
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
Q	LYS58
J	LYS58
K	LYS58
L	LYS58
M	LYS58
N	LYS58
O	LYS58
P	LYS58
R	LYS58

site_id	SWS_FT_FI10
Number of Residues	18
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
M	LYS324
N	LYS324
O	LYS324
P	LYS324
R	LYS324
Q	LYS324
J	LYS324
K	LYS324
L	LYS324

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)