Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8IXD

GMPCPP-Alpha1C/Beta2A-microtubule decorated with kinesin non-seam region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005929	cellular_component	cilium
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0030182	biological_process	neuron differentiation
A	0045121	cellular_component	membrane raft
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005881	cellular_component	cytoplasmic microtubule
B	0005929	cellular_component	cilium
B	0007017	biological_process	microtubule-based process
B	0015630	cellular_component	microtubule cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0030182	biological_process	neuron differentiation
B	0045121	cellular_component	membrane raft
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005881	cellular_component	cytoplasmic microtubule
C	0005929	cellular_component	cilium
C	0007017	biological_process	microtubule-based process
C	0015630	cellular_component	microtubule cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0030182	biological_process	neuron differentiation
C	0045121	cellular_component	membrane raft
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005881	cellular_component	cytoplasmic microtubule
D	0005929	cellular_component	cilium
D	0007017	biological_process	microtubule-based process
D	0015630	cellular_component	microtubule cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0030182	biological_process	neuron differentiation
D	0045121	cellular_component	membrane raft
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0005929	cellular_component	cilium
E	0007017	biological_process	microtubule-based process
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0030182	biological_process	neuron differentiation
E	0045121	cellular_component	membrane raft
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0005881	cellular_component	cytoplasmic microtubule
F	0005929	cellular_component	cilium
F	0007017	biological_process	microtubule-based process
F	0015630	cellular_component	microtubule cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0030182	biological_process	neuron differentiation
F	0045121	cellular_component	membrane raft
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000278	biological_process	mitotic cell cycle
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005881	cellular_component	cytoplasmic microtubule
G	0005929	cellular_component	cilium
G	0007017	biological_process	microtubule-based process
G	0015630	cellular_component	microtubule cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0030182	biological_process	neuron differentiation
G	0045121	cellular_component	membrane raft
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005881	cellular_component	cytoplasmic microtubule
H	0005929	cellular_component	cilium
H	0007017	biological_process	microtubule-based process
H	0015630	cellular_component	microtubule cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0030182	biological_process	neuron differentiation
H	0045121	cellular_component	membrane raft
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0000226	biological_process	microtubule cytoskeleton organization
I	0000278	biological_process	mitotic cell cycle
I	0005200	molecular_function	structural constituent of cytoskeleton
I	0005525	molecular_function	GTP binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005856	cellular_component	cytoskeleton
I	0005874	cellular_component	microtubule
I	0005881	cellular_component	cytoplasmic microtubule
I	0005929	cellular_component	cilium
I	0007017	biological_process	microtubule-based process
I	0015630	cellular_component	microtubule cytoskeleton
I	0016787	molecular_function	hydrolase activity
I	0030182	biological_process	neuron differentiation
I	0045121	cellular_component	membrane raft
I	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0000226	biological_process	microtubule cytoskeleton organization
J	0000278	biological_process	mitotic cell cycle
J	0001764	biological_process	neuron migration
J	0003924	molecular_function	GTPase activity
J	0005200	molecular_function	structural constituent of cytoskeleton
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005856	cellular_component	cytoskeleton
J	0005874	cellular_component	microtubule
J	0005929	cellular_component	cilium
J	0007017	biological_process	microtubule-based process
J	0015630	cellular_component	microtubule cytoskeleton
J	0021987	biological_process	cerebral cortex development
J	0045171	cellular_component	intercellular bridge
J	0046872	molecular_function	metal ion binding
J	0072686	cellular_component	mitotic spindle
J	0097228	cellular_component	sperm principal piece
J	0097229	cellular_component	sperm end piece
J	0097542	cellular_component	ciliary tip
K	0000166	molecular_function	nucleotide binding
K	0000226	biological_process	microtubule cytoskeleton organization
K	0000278	biological_process	mitotic cell cycle
K	0001764	biological_process	neuron migration
K	0003924	molecular_function	GTPase activity
K	0005200	molecular_function	structural constituent of cytoskeleton
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0005874	cellular_component	microtubule
K	0005929	cellular_component	cilium
K	0007017	biological_process	microtubule-based process
K	0015630	cellular_component	microtubule cytoskeleton
K	0021987	biological_process	cerebral cortex development
K	0045171	cellular_component	intercellular bridge
K	0046872	molecular_function	metal ion binding
K	0072686	cellular_component	mitotic spindle
K	0097228	cellular_component	sperm principal piece
K	0097229	cellular_component	sperm end piece
K	0097542	cellular_component	ciliary tip
L	0000166	molecular_function	nucleotide binding
L	0000226	biological_process	microtubule cytoskeleton organization
L	0000278	biological_process	mitotic cell cycle
L	0001764	biological_process	neuron migration
L	0003924	molecular_function	GTPase activity
L	0005200	molecular_function	structural constituent of cytoskeleton
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0005874	cellular_component	microtubule
L	0005929	cellular_component	cilium
L	0007017	biological_process	microtubule-based process
L	0015630	cellular_component	microtubule cytoskeleton
L	0021987	biological_process	cerebral cortex development
L	0045171	cellular_component	intercellular bridge
L	0046872	molecular_function	metal ion binding
L	0072686	cellular_component	mitotic spindle
L	0097228	cellular_component	sperm principal piece
L	0097229	cellular_component	sperm end piece
L	0097542	cellular_component	ciliary tip
M	0000166	molecular_function	nucleotide binding
M	0000226	biological_process	microtubule cytoskeleton organization
M	0000278	biological_process	mitotic cell cycle
M	0001764	biological_process	neuron migration
M	0003924	molecular_function	GTPase activity
M	0005200	molecular_function	structural constituent of cytoskeleton
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005856	cellular_component	cytoskeleton
M	0005874	cellular_component	microtubule
M	0005929	cellular_component	cilium
M	0007017	biological_process	microtubule-based process
M	0015630	cellular_component	microtubule cytoskeleton
M	0021987	biological_process	cerebral cortex development
M	0045171	cellular_component	intercellular bridge
M	0046872	molecular_function	metal ion binding
M	0072686	cellular_component	mitotic spindle
M	0097228	cellular_component	sperm principal piece
M	0097229	cellular_component	sperm end piece
M	0097542	cellular_component	ciliary tip
N	0000166	molecular_function	nucleotide binding
N	0000226	biological_process	microtubule cytoskeleton organization
N	0000278	biological_process	mitotic cell cycle
N	0001764	biological_process	neuron migration
N	0003924	molecular_function	GTPase activity
N	0005200	molecular_function	structural constituent of cytoskeleton
N	0005525	molecular_function	GTP binding
N	0005737	cellular_component	cytoplasm
N	0005856	cellular_component	cytoskeleton
N	0005874	cellular_component	microtubule
N	0005929	cellular_component	cilium
N	0007017	biological_process	microtubule-based process
N	0015630	cellular_component	microtubule cytoskeleton
N	0021987	biological_process	cerebral cortex development
N	0045171	cellular_component	intercellular bridge
N	0046872	molecular_function	metal ion binding
N	0072686	cellular_component	mitotic spindle
N	0097228	cellular_component	sperm principal piece
N	0097229	cellular_component	sperm end piece
N	0097542	cellular_component	ciliary tip
O	0000166	molecular_function	nucleotide binding
O	0000226	biological_process	microtubule cytoskeleton organization
O	0000278	biological_process	mitotic cell cycle
O	0001764	biological_process	neuron migration
O	0003924	molecular_function	GTPase activity
O	0005200	molecular_function	structural constituent of cytoskeleton
O	0005525	molecular_function	GTP binding
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0005874	cellular_component	microtubule
O	0005929	cellular_component	cilium
O	0007017	biological_process	microtubule-based process
O	0015630	cellular_component	microtubule cytoskeleton
O	0021987	biological_process	cerebral cortex development
O	0045171	cellular_component	intercellular bridge
O	0046872	molecular_function	metal ion binding
O	0072686	cellular_component	mitotic spindle
O	0097228	cellular_component	sperm principal piece
O	0097229	cellular_component	sperm end piece
O	0097542	cellular_component	ciliary tip
P	0000166	molecular_function	nucleotide binding
P	0000226	biological_process	microtubule cytoskeleton organization
P	0000278	biological_process	mitotic cell cycle
P	0001764	biological_process	neuron migration
P	0003924	molecular_function	GTPase activity
P	0005200	molecular_function	structural constituent of cytoskeleton
P	0005525	molecular_function	GTP binding
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0005874	cellular_component	microtubule
P	0005929	cellular_component	cilium
P	0007017	biological_process	microtubule-based process
P	0015630	cellular_component	microtubule cytoskeleton
P	0021987	biological_process	cerebral cortex development
P	0045171	cellular_component	intercellular bridge
P	0046872	molecular_function	metal ion binding
P	0072686	cellular_component	mitotic spindle
P	0097228	cellular_component	sperm principal piece
P	0097229	cellular_component	sperm end piece
P	0097542	cellular_component	ciliary tip
Q	0000166	molecular_function	nucleotide binding
Q	0000226	biological_process	microtubule cytoskeleton organization
Q	0000278	biological_process	mitotic cell cycle
Q	0001764	biological_process	neuron migration
Q	0003924	molecular_function	GTPase activity
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0005929	cellular_component	cilium
Q	0007017	biological_process	microtubule-based process
Q	0015630	cellular_component	microtubule cytoskeleton
Q	0021987	biological_process	cerebral cortex development
Q	0045171	cellular_component	intercellular bridge
Q	0046872	molecular_function	metal ion binding
Q	0072686	cellular_component	mitotic spindle
Q	0097228	cellular_component	sperm principal piece
Q	0097229	cellular_component	sperm end piece
Q	0097542	cellular_component	ciliary tip
R	0000166	molecular_function	nucleotide binding
R	0000226	biological_process	microtubule cytoskeleton organization
R	0000278	biological_process	mitotic cell cycle
R	0001764	biological_process	neuron migration
R	0003924	molecular_function	GTPase activity
R	0005200	molecular_function	structural constituent of cytoskeleton
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0005856	cellular_component	cytoskeleton
R	0005874	cellular_component	microtubule
R	0005929	cellular_component	cilium
R	0007017	biological_process	microtubule-based process
R	0015630	cellular_component	microtubule cytoskeleton
R	0021987	biological_process	cerebral cortex development
R	0045171	cellular_component	intercellular bridge
R	0046872	molecular_function	metal ion binding
R	0072686	cellular_component	mitotic spindle
R	0097228	cellular_component	sperm principal piece
R	0097229	cellular_component	sperm end piece
R	0097542	cellular_component	ciliary tip
S	0003777	molecular_function	microtubule motor activity
S	0005524	molecular_function	ATP binding
S	0007018	biological_process	microtubule-based movement
S	0008017	molecular_function	microtubule binding
T	0003777	molecular_function	microtubule motor activity
T	0005524	molecular_function	ATP binding
T	0007018	biological_process	microtubule-based movement
T	0008017	molecular_function	microtubule binding
U	0003777	molecular_function	microtubule motor activity
U	0005524	molecular_function	ATP binding
U	0007018	biological_process	microtubule-based movement
U	0008017	molecular_function	microtubule binding
V	0003777	molecular_function	microtubule motor activity
V	0005524	molecular_function	ATP binding
V	0007018	biological_process	microtubule-based movement
V	0008017	molecular_function	microtubule binding
W	0003777	molecular_function	microtubule motor activity
W	0005524	molecular_function	ATP binding
W	0007018	biological_process	microtubule-based movement
W	0008017	molecular_function	microtubule binding
X	0003777	molecular_function	microtubule motor activity
X	0005524	molecular_function	ATP binding
X	0007018	biological_process	microtubule-based movement
X	0008017	molecular_function	microtubule binding
Y	0003777	molecular_function	microtubule motor activity
Y	0005524	molecular_function	ATP binding
Y	0007018	biological_process	microtubule-based movement
Y	0008017	molecular_function	microtubule binding
Z	0003777	molecular_function	microtubule motor activity
Z	0005524	molecular_function	ATP binding
Z	0007018	biological_process	microtubule-based movement
Z	0008017	molecular_function	microtubule binding
a	0003777	molecular_function	microtubule motor activity
a	0005524	molecular_function	ATP binding
a	0007018	biological_process	microtubule-based movement
a	0008017	molecular_function	microtubule binding

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
I	GLY148-GLY154
Q	GLY140-GLY146

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
Q	MET1-ILE4

site_id	PS00356
Number of Residues	19
Details	HTH_LACI_1 LacI-type HTH domain signature. LvDLAgsAkVSktGAegAV

Chain	Residue	Details
a	LEU229-VAL247

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	81
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	9
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"PubMed","id":"16800626","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	9
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9BQE3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	27
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	63
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	9
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	9
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	9
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	18
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	9
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	9
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	18
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2853
Details	Domain: {"description":"Kinesin motor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00283","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	63
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	18
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)