Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8IXB

GMPCPP-Alpha1A/Beta2A-microtubule decorated with kinesin seam region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0000793	cellular_component	condensed chromosome
A	0001764	biological_process	neuron migration
A	0001964	biological_process	startle response
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005879	cellular_component	axonemal microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006458	biological_process	'de novo' protein folding
A	0006886	biological_process	intracellular protein transport
A	0007017	biological_process	microtubule-based process
A	0007098	biological_process	centrosome cycle
A	0007224	biological_process	smoothened signaling pathway
A	0007613	biological_process	memory
A	0007626	biological_process	locomotory behavior
A	0008017	molecular_function	microtubule binding
A	0008344	biological_process	adult locomotory behavior
A	0008542	biological_process	visual learning
A	0009612	biological_process	response to mechanical stimulus
A	0010001	biological_process	glial cell differentiation
A	0010467	biological_process	gene expression
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0019904	molecular_function	protein domain specific binding
A	0021542	biological_process	dentate gyrus development
A	0021696	biological_process	cerebellar cortex morphogenesis
A	0021766	biological_process	hippocampus development
A	0021859	biological_process	pyramidal neuron differentiation
A	0021987	biological_process	cerebral cortex development
A	0022008	biological_process	neurogenesis
A	0030182	biological_process	neuron differentiation
A	0030317	biological_process	flagellated sperm motility
A	0030534	biological_process	adult behavior
A	0031594	cellular_component	neuromuscular junction
A	0034612	biological_process	response to tumor necrosis factor
A	0035641	biological_process	locomotory exploration behavior
A	0036126	cellular_component	sperm flagellum
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042802	molecular_function	identical protein binding
A	0043209	cellular_component	myelin sheath
A	0044877	molecular_function	protein-containing complex binding
A	0045121	cellular_component	membrane raft
A	0045202	cellular_component	synapse
A	0046785	biological_process	microtubule polymerization
A	0046872	molecular_function	metal ion binding
A	0046982	molecular_function	protein heterodimerization activity
A	0048853	biological_process	forebrain morphogenesis
A	0048873	biological_process	homeostasis of number of cells within a tissue
A	0050807	biological_process	regulation of synapse organization
A	0050808	biological_process	synapse organization
A	0050821	biological_process	protein stabilization
A	0051087	molecular_function	protein-folding chaperone binding
A	0051402	biological_process	neuron apoptotic process
A	0055037	cellular_component	recycling endosome
A	0061744	biological_process	motor behavior
A	0071277	biological_process	cellular response to calcium ion
A	0072384	biological_process	organelle transport along microtubule
A	0140058	biological_process	neuron projection arborization
A	1902065	biological_process	response to L-glutamate
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000278	biological_process	mitotic cell cycle
E	0000793	cellular_component	condensed chromosome
E	0001764	biological_process	neuron migration
E	0001964	biological_process	startle response
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005879	cellular_component	axonemal microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0005886	cellular_component	plasma membrane
E	0005929	cellular_component	cilium
E	0006458	biological_process	'de novo' protein folding
E	0006886	biological_process	intracellular protein transport
E	0007017	biological_process	microtubule-based process
E	0007098	biological_process	centrosome cycle
E	0007224	biological_process	smoothened signaling pathway
E	0007613	biological_process	memory
E	0007626	biological_process	locomotory behavior
E	0008017	molecular_function	microtubule binding
E	0008344	biological_process	adult locomotory behavior
E	0008542	biological_process	visual learning
E	0009612	biological_process	response to mechanical stimulus
E	0010001	biological_process	glial cell differentiation
E	0010467	biological_process	gene expression
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0019904	molecular_function	protein domain specific binding
E	0021542	biological_process	dentate gyrus development
E	0021696	biological_process	cerebellar cortex morphogenesis
E	0021766	biological_process	hippocampus development
E	0021859	biological_process	pyramidal neuron differentiation
E	0021987	biological_process	cerebral cortex development
E	0022008	biological_process	neurogenesis
E	0030182	biological_process	neuron differentiation
E	0030317	biological_process	flagellated sperm motility
E	0030534	biological_process	adult behavior
E	0031594	cellular_component	neuromuscular junction
E	0034612	biological_process	response to tumor necrosis factor
E	0035641	biological_process	locomotory exploration behavior
E	0036126	cellular_component	sperm flagellum
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0042802	molecular_function	identical protein binding
E	0043209	cellular_component	myelin sheath
E	0044877	molecular_function	protein-containing complex binding
E	0045121	cellular_component	membrane raft
E	0045202	cellular_component	synapse
E	0046785	biological_process	microtubule polymerization
E	0046872	molecular_function	metal ion binding
E	0046982	molecular_function	protein heterodimerization activity
E	0048853	biological_process	forebrain morphogenesis
E	0048873	biological_process	homeostasis of number of cells within a tissue
E	0050807	biological_process	regulation of synapse organization
E	0050808	biological_process	synapse organization
E	0050821	biological_process	protein stabilization
E	0051087	molecular_function	protein-folding chaperone binding
E	0051402	biological_process	neuron apoptotic process
E	0055037	cellular_component	recycling endosome
E	0061744	biological_process	motor behavior
E	0071277	biological_process	cellular response to calcium ion
E	0072384	biological_process	organelle transport along microtubule
E	0140058	biological_process	neuron projection arborization
E	1902065	biological_process	response to L-glutamate
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000278	biological_process	mitotic cell cycle
F	0000793	cellular_component	condensed chromosome
F	0001764	biological_process	neuron migration
F	0001964	biological_process	startle response
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0005879	cellular_component	axonemal microtubule
F	0005881	cellular_component	cytoplasmic microtubule
F	0005886	cellular_component	plasma membrane
F	0005929	cellular_component	cilium
F	0006458	biological_process	'de novo' protein folding
F	0006886	biological_process	intracellular protein transport
F	0007017	biological_process	microtubule-based process
F	0007098	biological_process	centrosome cycle
F	0007224	biological_process	smoothened signaling pathway
F	0007613	biological_process	memory
F	0007626	biological_process	locomotory behavior
F	0008017	molecular_function	microtubule binding
F	0008344	biological_process	adult locomotory behavior
F	0008542	biological_process	visual learning
F	0009612	biological_process	response to mechanical stimulus
F	0010001	biological_process	glial cell differentiation
F	0010467	biological_process	gene expression
F	0015630	cellular_component	microtubule cytoskeleton
F	0016787	molecular_function	hydrolase activity
F	0019904	molecular_function	protein domain specific binding
F	0021542	biological_process	dentate gyrus development
F	0021696	biological_process	cerebellar cortex morphogenesis
F	0021766	biological_process	hippocampus development
F	0021859	biological_process	pyramidal neuron differentiation
F	0021987	biological_process	cerebral cortex development
F	0022008	biological_process	neurogenesis
F	0030182	biological_process	neuron differentiation
F	0030317	biological_process	flagellated sperm motility
F	0030534	biological_process	adult behavior
F	0031594	cellular_component	neuromuscular junction
F	0034612	biological_process	response to tumor necrosis factor
F	0035641	biological_process	locomotory exploration behavior
F	0036126	cellular_component	sperm flagellum
F	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
F	0042802	molecular_function	identical protein binding
F	0043209	cellular_component	myelin sheath
F	0044877	molecular_function	protein-containing complex binding
F	0045121	cellular_component	membrane raft
F	0045202	cellular_component	synapse
F	0046785	biological_process	microtubule polymerization
F	0046872	molecular_function	metal ion binding
F	0046982	molecular_function	protein heterodimerization activity
F	0048853	biological_process	forebrain morphogenesis
F	0048873	biological_process	homeostasis of number of cells within a tissue
F	0050807	biological_process	regulation of synapse organization
F	0050808	biological_process	synapse organization
F	0050821	biological_process	protein stabilization
F	0051087	molecular_function	protein-folding chaperone binding
F	0051402	biological_process	neuron apoptotic process
F	0055037	cellular_component	recycling endosome
F	0061744	biological_process	motor behavior
F	0071277	biological_process	cellular response to calcium ion
F	0072384	biological_process	organelle transport along microtubule
F	0140058	biological_process	neuron projection arborization
F	1902065	biological_process	response to L-glutamate
H	0000166	molecular_function	nucleotide binding
H	0000226	biological_process	microtubule cytoskeleton organization
H	0000278	biological_process	mitotic cell cycle
H	0000793	cellular_component	condensed chromosome
H	0001764	biological_process	neuron migration
H	0001964	biological_process	startle response
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0005879	cellular_component	axonemal microtubule
H	0005881	cellular_component	cytoplasmic microtubule
H	0005886	cellular_component	plasma membrane
H	0005929	cellular_component	cilium
H	0006458	biological_process	'de novo' protein folding
H	0006886	biological_process	intracellular protein transport
H	0007017	biological_process	microtubule-based process
H	0007098	biological_process	centrosome cycle
H	0007224	biological_process	smoothened signaling pathway
H	0007613	biological_process	memory
H	0007626	biological_process	locomotory behavior
H	0008017	molecular_function	microtubule binding
H	0008344	biological_process	adult locomotory behavior
H	0008542	biological_process	visual learning
H	0009612	biological_process	response to mechanical stimulus
H	0010001	biological_process	glial cell differentiation
H	0010467	biological_process	gene expression
H	0015630	cellular_component	microtubule cytoskeleton
H	0016787	molecular_function	hydrolase activity
H	0019904	molecular_function	protein domain specific binding
H	0021542	biological_process	dentate gyrus development
H	0021696	biological_process	cerebellar cortex morphogenesis
H	0021766	biological_process	hippocampus development
H	0021859	biological_process	pyramidal neuron differentiation
H	0021987	biological_process	cerebral cortex development
H	0022008	biological_process	neurogenesis
H	0030182	biological_process	neuron differentiation
H	0030317	biological_process	flagellated sperm motility
H	0030534	biological_process	adult behavior
H	0031594	cellular_component	neuromuscular junction
H	0034612	biological_process	response to tumor necrosis factor
H	0035641	biological_process	locomotory exploration behavior
H	0036126	cellular_component	sperm flagellum
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0042802	molecular_function	identical protein binding
H	0043209	cellular_component	myelin sheath
H	0044877	molecular_function	protein-containing complex binding
H	0045121	cellular_component	membrane raft
H	0045202	cellular_component	synapse
H	0046785	biological_process	microtubule polymerization
H	0046872	molecular_function	metal ion binding
H	0046982	molecular_function	protein heterodimerization activity
H	0048853	biological_process	forebrain morphogenesis
H	0048873	biological_process	homeostasis of number of cells within a tissue
H	0050807	biological_process	regulation of synapse organization
H	0050808	biological_process	synapse organization
H	0050821	biological_process	protein stabilization
H	0051087	molecular_function	protein-folding chaperone binding
H	0051402	biological_process	neuron apoptotic process
H	0055037	cellular_component	recycling endosome
H	0061744	biological_process	motor behavior
H	0071277	biological_process	cellular response to calcium ion
H	0072384	biological_process	organelle transport along microtubule
H	0140058	biological_process	neuron projection arborization
H	1902065	biological_process	response to L-glutamate
Q	0000166	molecular_function	nucleotide binding
Q	0000226	biological_process	microtubule cytoskeleton organization
Q	0000278	biological_process	mitotic cell cycle
Q	0001764	biological_process	neuron migration
Q	0003924	molecular_function	GTPase activity
Q	0005200	molecular_function	structural constituent of cytoskeleton
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0005856	cellular_component	cytoskeleton
Q	0005874	cellular_component	microtubule
Q	0005929	cellular_component	cilium
Q	0007017	biological_process	microtubule-based process
Q	0015630	cellular_component	microtubule cytoskeleton
Q	0021987	biological_process	cerebral cortex development
Q	0045171	cellular_component	intercellular bridge
Q	0046872	molecular_function	metal ion binding
Q	0072686	cellular_component	mitotic spindle
Q	0097228	cellular_component	sperm principal piece
Q	0097229	cellular_component	sperm end piece
Q	0097542	cellular_component	ciliary tip
U	0000166	molecular_function	nucleotide binding
U	0000226	biological_process	microtubule cytoskeleton organization
U	0000278	biological_process	mitotic cell cycle
U	0001764	biological_process	neuron migration
U	0003924	molecular_function	GTPase activity
U	0005200	molecular_function	structural constituent of cytoskeleton
U	0005525	molecular_function	GTP binding
U	0005737	cellular_component	cytoplasm
U	0005856	cellular_component	cytoskeleton
U	0005874	cellular_component	microtubule
U	0005929	cellular_component	cilium
U	0007017	biological_process	microtubule-based process
U	0015630	cellular_component	microtubule cytoskeleton
U	0021987	biological_process	cerebral cortex development
U	0045171	cellular_component	intercellular bridge
U	0046872	molecular_function	metal ion binding
U	0072686	cellular_component	mitotic spindle
U	0097228	cellular_component	sperm principal piece
U	0097229	cellular_component	sperm end piece
U	0097542	cellular_component	ciliary tip
V	0000166	molecular_function	nucleotide binding
V	0000226	biological_process	microtubule cytoskeleton organization
V	0000278	biological_process	mitotic cell cycle
V	0001764	biological_process	neuron migration
V	0003924	molecular_function	GTPase activity
V	0005200	molecular_function	structural constituent of cytoskeleton
V	0005525	molecular_function	GTP binding
V	0005737	cellular_component	cytoplasm
V	0005856	cellular_component	cytoskeleton
V	0005874	cellular_component	microtubule
V	0005929	cellular_component	cilium
V	0007017	biological_process	microtubule-based process
V	0015630	cellular_component	microtubule cytoskeleton
V	0021987	biological_process	cerebral cortex development
V	0045171	cellular_component	intercellular bridge
V	0046872	molecular_function	metal ion binding
V	0072686	cellular_component	mitotic spindle
V	0097228	cellular_component	sperm principal piece
V	0097229	cellular_component	sperm end piece
V	0097542	cellular_component	ciliary tip
W	0000166	molecular_function	nucleotide binding
W	0000226	biological_process	microtubule cytoskeleton organization
W	0000278	biological_process	mitotic cell cycle
W	0001764	biological_process	neuron migration
W	0003924	molecular_function	GTPase activity
W	0005200	molecular_function	structural constituent of cytoskeleton
W	0005525	molecular_function	GTP binding
W	0005737	cellular_component	cytoplasm
W	0005856	cellular_component	cytoskeleton
W	0005874	cellular_component	microtubule
W	0005929	cellular_component	cilium
W	0007017	biological_process	microtubule-based process
W	0015630	cellular_component	microtubule cytoskeleton
W	0021987	biological_process	cerebral cortex development
W	0045171	cellular_component	intercellular bridge
W	0046872	molecular_function	metal ion binding
W	0072686	cellular_component	mitotic spindle
W	0097228	cellular_component	sperm principal piece
W	0097229	cellular_component	sperm end piece
W	0097542	cellular_component	ciliary tip
g	0003777	molecular_function	microtubule motor activity
g	0005524	molecular_function	ATP binding
g	0007018	biological_process	microtubule-based movement
g	0008017	molecular_function	microtubule binding
k	0003777	molecular_function	microtubule motor activity
k	0005524	molecular_function	ATP binding
k	0007018	biological_process	microtubule-based movement
k	0008017	molecular_function	microtubule binding
l	0003777	molecular_function	microtubule motor activity
l	0005524	molecular_function	ATP binding
l	0007018	biological_process	microtubule-based movement
l	0008017	molecular_function	microtubule binding
m	0003777	molecular_function	microtubule motor activity
m	0005524	molecular_function	ATP binding
m	0007018	biological_process	microtubule-based movement
m	0008017	molecular_function	microtubule binding

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
W	GLY140-GLY146
H	GLY148-GLY154

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
W	MET1-ILE4

site_id	PS00356
Number of Residues	19
Details	HTH_LACI_1 LacI-type HTH domain signature. LvDLAgsAkVSktGAegAV

Chain	Residue	Details
l	LEU229-VAL247

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1268
Details	Domain: {"description":"Kinesin motor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00283","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	28
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)