8IWE
Cryo-EM structure of the SPE-mTAAR9 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| R | 0001594 | molecular_function | trace-amine receptor activity |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| R | 0008227 | molecular_function | G protein-coupled amine receptor activity |
| R | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASLfHLCCISIDRYIaV |
| Chain | Residue | Details |
| R | ALA118-VAL134 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"37225986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ITF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37225986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ITF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"37225986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ITF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 26 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37225986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ITF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"37225986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ITF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"37225986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ITF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"37225986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ITF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"37225986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ITF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"37225986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ITF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37225986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IW4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IWE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
