Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8IPT

Cryo-EM structure of heme transporter CydDC from Escherichia coli in the occluded ATP bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006865	biological_process	amino acid transport
A	0006869	biological_process	lipid transport
A	0015439	molecular_function	ABC-type heme transporter activity
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0033228	biological_process	cysteine export across plasma membrane
A	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
A	0034775	biological_process	glutathione transmembrane transport
A	0035351	biological_process	heme transmembrane transport
A	0042883	biological_process	cysteine transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0045454	biological_process	cell redox homeostasis
A	0055051	cellular_component	ATP-binding cassette (ABC) transporter complex, integrated substrate binding
A	0055085	biological_process	transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
A	1903605	biological_process	cytochrome biosynthetic process
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006865	biological_process	amino acid transport
C	0015439	molecular_function	ABC-type heme transporter activity
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0033228	biological_process	cysteine export across plasma membrane
C	0034775	biological_process	glutathione transmembrane transport
C	0035351	biological_process	heme transmembrane transport
C	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0045454	biological_process	cell redox homeostasis
C	0055051	cellular_component	ATP-binding cassette (ABC) transporter complex, integrated substrate binding
C	0055085	biological_process	transmembrane transport
C	0140359	molecular_function	ABC-type transporter activity
C	1903605	biological_process	cytochrome biosynthetic process
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0006865	biological_process	amino acid transport
D	0015439	molecular_function	ABC-type heme transporter activity
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0033228	biological_process	cysteine export across plasma membrane
D	0034775	biological_process	glutathione transmembrane transport
D	0035351	biological_process	heme transmembrane transport
D	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0045454	biological_process	cell redox homeostasis
D	0055051	cellular_component	ATP-binding cassette (ABC) transporter complex, integrated substrate binding
D	0055085	biological_process	transmembrane transport
D	0140359	molecular_function	ABC-type transporter activity
D	1903605	biological_process	cytochrome biosynthetic process
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0006865	biological_process	amino acid transport
E	0006869	biological_process	lipid transport
E	0015439	molecular_function	ABC-type heme transporter activity
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0033228	biological_process	cysteine export across plasma membrane
E	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
E	0034775	biological_process	glutathione transmembrane transport
E	0035351	biological_process	heme transmembrane transport
E	0042883	biological_process	cysteine transport
E	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
E	0045454	biological_process	cell redox homeostasis
E	0055051	cellular_component	ATP-binding cassette (ABC) transporter complex, integrated substrate binding
E	0055085	biological_process	transmembrane transport
E	0140359	molecular_function	ABC-type transporter activity
E	1903605	biological_process	cytochrome biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSVGQAQRVAVARAL

Chain	Residue	Details
A	LEU486-LEU500
C	LEU475-LEU489

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	866
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:15470119

Chain	Residue	Details
C	MET1-LYS15
C	ASN58-ARG136
C	ARG183-ALA249
C	THR298-LEU573
D	MET1-LYS15
D	ASN58-ARG136
D	ARG183-ALA249
D	THR298-LEU573

site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	TRP16-LEU36
D	LEU162-TYR182
D	ILE250-VAL270
D	GLY277-VAL297
C	THR37-PHE57
C	VAL137-PHE157
C	LEU162-TYR182
C	ILE250-VAL270
C	GLY277-VAL297
D	TRP16-LEU36
D	THR37-PHE57
D	VAL137-PHE157

site_id	SWS_FT_FI3
Number of Residues	16
Details	TOPO_DOM: Periplasmic => ECO:0000269\|PubMed:15470119

Chain	Residue	Details
C	LEU158-THR161
C	GLY271-PRO276
D	LEU158-THR161
D	GLY271-PRO276

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00434

Chain	Residue	Details
C	GLY373
D	GLY373

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)