8IP5

Cryo-EM structure of hMRS2-lowEDTA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006089	biological_process	lactate metabolic process
A	0006811	biological_process	monoatomic ion transport
A	0015095	molecular_function	magnesium ion transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0045016	biological_process	mitochondrial magnesium ion transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006089	biological_process	lactate metabolic process
B	0006811	biological_process	monoatomic ion transport
B	0015095	molecular_function	magnesium ion transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0045016	biological_process	mitochondrial magnesium ion transmembrane transport
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006089	biological_process	lactate metabolic process
C	0006811	biological_process	monoatomic ion transport
C	0015095	molecular_function	magnesium ion transmembrane transporter activity
C	0016020	cellular_component	membrane
C	0045016	biological_process	mitochondrial magnesium ion transmembrane transport
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006089	biological_process	lactate metabolic process
D	0006811	biological_process	monoatomic ion transport
D	0015095	molecular_function	magnesium ion transmembrane transporter activity
D	0016020	cellular_component	membrane
D	0045016	biological_process	mitochondrial magnesium ion transmembrane transport
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006089	biological_process	lactate metabolic process
E	0006811	biological_process	monoatomic ion transport
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0016020	cellular_component	membrane
E	0045016	biological_process	mitochondrial magnesium ion transmembrane transport
E	0046872	molecular_function	metal ion binding
E	0055085	biological_process	transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	95
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"37543649","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37938562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39609651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IP3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"37543649","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37938562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39609651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IP3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	150
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"37543649","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37938562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39609651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IP3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Motif: {"description":"GMN motif","evidences":[{"source":"PubMed","id":"37543649","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37938562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39609651","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37543649","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37938562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39609651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IP3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37543649","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37938562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39609651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IP3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37543649","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37938562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39609651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IP3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37543649","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37938562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39609651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8IP3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TS1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TUP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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