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8IO4

Herg1a-herg1b open state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000976molecular_functiontranscription cis-regulatory region binding
A0003064biological_processregulation of heart rate by hormone
A0005216molecular_functionmonoatomic ion channel activity
A0005242molecular_functioninward rectifier potassium channel activity
A0005249molecular_functionvoltage-gated potassium channel activity
A0005251molecular_functiondelayed rectifier potassium channel activity
A0005267molecular_functionpotassium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0008076cellular_componentvoltage-gated potassium channel complex
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0031625molecular_functionubiquitin protein ligase binding
A0034702cellular_componentmonoatomic ion channel complex
A0042391biological_processregulation of membrane potential
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0045893biological_processpositive regulation of DNA-templated transcription
A0048471cellular_componentperinuclear region of cytoplasm
A0055075biological_processpotassium ion homeostasis
A0055085biological_processtransmembrane transport
A0060048biological_processcardiac muscle contraction
A0060306biological_processregulation of membrane repolarization
A0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
A0071466biological_processcellular response to xenobiotic stimulus
A0071805biological_processpotassium ion transmembrane transport
A0086005biological_processventricular cardiac muscle cell action potential
A0086009biological_processmembrane repolarization
A0086010biological_processmembrane depolarization during action potential
A0086011biological_processmembrane repolarization during action potential
A0086013biological_processmembrane repolarization during cardiac muscle cell action potential
A0086091biological_processregulation of heart rate by cardiac conduction
A0097110molecular_functionscaffold protein binding
A0097623biological_processpotassium ion export across plasma membrane
A0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
A1901379biological_processregulation of potassium ion transmembrane transport
A1901380biological_processnegative regulation of potassium ion transmembrane transport
A1901381biological_processpositive regulation of potassium ion transmembrane transport
A1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
A1902937cellular_componentinward rectifier potassium channel complex
A1903765biological_processnegative regulation of potassium ion export across plasma membrane
A1990573biological_processpotassium ion import across plasma membrane
B0000976molecular_functiontranscription cis-regulatory region binding
B0003064biological_processregulation of heart rate by hormone
B0005216molecular_functionmonoatomic ion channel activity
B0005242molecular_functioninward rectifier potassium channel activity
B0005249molecular_functionvoltage-gated potassium channel activity
B0005251molecular_functiondelayed rectifier potassium channel activity
B0005267molecular_functionpotassium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006813biological_processpotassium ion transport
B0008076cellular_componentvoltage-gated potassium channel complex
B0009986cellular_componentcell surface
B0016020cellular_componentmembrane
B0031625molecular_functionubiquitin protein ligase binding
B0034702cellular_componentmonoatomic ion channel complex
B0042391biological_processregulation of membrane potential
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0045893biological_processpositive regulation of DNA-templated transcription
B0048471cellular_componentperinuclear region of cytoplasm
B0055075biological_processpotassium ion homeostasis
B0055085biological_processtransmembrane transport
B0060048biological_processcardiac muscle contraction
B0060306biological_processregulation of membrane repolarization
B0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
B0071466biological_processcellular response to xenobiotic stimulus
B0071805biological_processpotassium ion transmembrane transport
B0086005biological_processventricular cardiac muscle cell action potential
B0086009biological_processmembrane repolarization
B0086010biological_processmembrane depolarization during action potential
B0086011biological_processmembrane repolarization during action potential
B0086013biological_processmembrane repolarization during cardiac muscle cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0097110molecular_functionscaffold protein binding
B0097623biological_processpotassium ion export across plasma membrane
B0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
B1901379biological_processregulation of potassium ion transmembrane transport
B1901380biological_processnegative regulation of potassium ion transmembrane transport
B1901381biological_processpositive regulation of potassium ion transmembrane transport
B1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
B1902937cellular_componentinward rectifier potassium channel complex
B1903765biological_processnegative regulation of potassium ion export across plasma membrane
B1990573biological_processpotassium ion import across plasma membrane
C0000976molecular_functiontranscription cis-regulatory region binding
C0003064biological_processregulation of heart rate by hormone
C0005216molecular_functionmonoatomic ion channel activity
C0005242molecular_functioninward rectifier potassium channel activity
C0005249molecular_functionvoltage-gated potassium channel activity
C0005251molecular_functiondelayed rectifier potassium channel activity
C0005267molecular_functionpotassium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0008076cellular_componentvoltage-gated potassium channel complex
C0009986cellular_componentcell surface
C0016020cellular_componentmembrane
C0031625molecular_functionubiquitin protein ligase binding
C0034702cellular_componentmonoatomic ion channel complex
C0042391biological_processregulation of membrane potential
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0045893biological_processpositive regulation of DNA-templated transcription
C0048471cellular_componentperinuclear region of cytoplasm
C0055075biological_processpotassium ion homeostasis
C0055085biological_processtransmembrane transport
C0060048biological_processcardiac muscle contraction
C0060306biological_processregulation of membrane repolarization
C0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
C0071466biological_processcellular response to xenobiotic stimulus
C0071805biological_processpotassium ion transmembrane transport
C0086005biological_processventricular cardiac muscle cell action potential
C0086009biological_processmembrane repolarization
C0086010biological_processmembrane depolarization during action potential
C0086011biological_processmembrane repolarization during action potential
C0086013biological_processmembrane repolarization during cardiac muscle cell action potential
C0086091biological_processregulation of heart rate by cardiac conduction
C0097110molecular_functionscaffold protein binding
C0097623biological_processpotassium ion export across plasma membrane
C0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
C1901379biological_processregulation of potassium ion transmembrane transport
C1901380biological_processnegative regulation of potassium ion transmembrane transport
C1901381biological_processpositive regulation of potassium ion transmembrane transport
C1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C1902937cellular_componentinward rectifier potassium channel complex
C1903765biological_processnegative regulation of potassium ion export across plasma membrane
C1990573biological_processpotassium ion import across plasma membrane
D0000976molecular_functiontranscription cis-regulatory region binding
D0003064biological_processregulation of heart rate by hormone
D0005216molecular_functionmonoatomic ion channel activity
D0005242molecular_functioninward rectifier potassium channel activity
D0005249molecular_functionvoltage-gated potassium channel activity
D0005251molecular_functiondelayed rectifier potassium channel activity
D0005267molecular_functionpotassium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0008076cellular_componentvoltage-gated potassium channel complex
D0009986cellular_componentcell surface
D0016020cellular_componentmembrane
D0031625molecular_functionubiquitin protein ligase binding
D0034702cellular_componentmonoatomic ion channel complex
D0042391biological_processregulation of membrane potential
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0045893biological_processpositive regulation of DNA-templated transcription
D0048471cellular_componentperinuclear region of cytoplasm
D0055075biological_processpotassium ion homeostasis
D0055085biological_processtransmembrane transport
D0060048biological_processcardiac muscle contraction
D0060306biological_processregulation of membrane repolarization
D0060307biological_processregulation of ventricular cardiac muscle cell membrane repolarization
D0071466biological_processcellular response to xenobiotic stimulus
D0071805biological_processpotassium ion transmembrane transport
D0086005biological_processventricular cardiac muscle cell action potential
D0086009biological_processmembrane repolarization
D0086010biological_processmembrane depolarization during action potential
D0086011biological_processmembrane repolarization during action potential
D0086013biological_processmembrane repolarization during cardiac muscle cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0097110molecular_functionscaffold protein binding
D0097623biological_processpotassium ion export across plasma membrane
D0098915biological_processmembrane repolarization during ventricular cardiac muscle cell action potential
D1901379biological_processregulation of potassium ion transmembrane transport
D1901380biological_processnegative regulation of potassium ion transmembrane transport
D1901381biological_processpositive regulation of potassium ion transmembrane transport
D1902282molecular_functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
D1902937cellular_componentinward rectifier potassium channel complex
D1903765biological_processnegative regulation of potassium ion export across plasma membrane
D1990573biological_processpotassium ion import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3716
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-TYR403
DARG472-LYS495
DTYR542-ALA547
DSER660-SER1159
BMET1-TYR403
BARG472-LYS495
BTYR542-ALA547
BSER660-SER1159
AARG472-LYS495
ATYR542-ALA547
ASER660-SER1159
CMET1-TYR403
CARG472-LYS495
CTYR542-ALA547
CSER660-SER1159
DMET1-TYR403

site_idSWS_FT_FI2
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S1 => ECO:0000255
ChainResidueDetails
ASER404-PHE424
CSER404-PHE424
DSER404-PHE424
BSER404-PHE424

site_idSWS_FT_FI3
Number of Residues300
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ATHR425-GLN450
DSER517-LEU520
DTYR569-TYR611
DASN633-LYS638
BTHR425-GLN450
BSER517-LEU520
BTYR569-TYR611
BASN633-LYS638
ASER517-LEU520
ATYR569-TYR611
AASN633-LYS638
CTHR425-GLN450
CSER517-LEU520
CTYR569-TYR611
CASN633-LYS638
DTHR425-GLN450

site_idSWS_FT_FI4
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S2 => ECO:0000255
ChainResidueDetails
APRO451-PHE471
CPRO451-PHE471
DPRO451-PHE471
BPRO451-PHE471

site_idSWS_FT_FI5
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S3 => ECO:0000255
ChainResidueDetails
AGLY496-GLY516
CGLY496-GLY516
DGLY496-GLY516
BGLY496-GLY516

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000255
ChainResidueDetails
AILE521-ARG541
CILE521-ARG541
DILE521-ARG541
BILE521-ARG541

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S5 => ECO:0000255
ChainResidueDetails
AALA548-TRP568
CALA548-TRP568
DALA548-TRP568
BALA548-TRP568

site_idSWS_FT_FI8
Number of Residues80
DetailsINTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000255
ChainResidueDetails
AVAL612-PRO632
CVAL612-PRO632
DVAL612-PRO632
BVAL612-PRO632

site_idSWS_FT_FI9
Number of Residues80
DetailsTRANSMEM: Helical; Name=Segment S6 => ECO:0000255
ChainResidueDetails
AILE639-VAL659
CILE639-VAL659
DILE639-VAL659
BILE639-VAL659

site_idSWS_FT_FI10
Number of Residues4
DetailsBINDING:
ChainResidueDetails
APRO742
CPRO742
DPRO742
BPRO742

site_idSWS_FT_FI11
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER239
BSER239
BSER871
BSER1137
ASER871
ASER1137
CSER239
CSER871
CSER1137
DSER239
DSER871
DSER1137

site_idSWS_FT_FI12
Number of Residues16
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O35219
ChainResidueDetails
ASER243
DSER283
DSER284
DSER874
BSER243
BSER283
BSER284
BSER874
ASER283
ASER284
ASER874
CSER243
CSER283
CSER284
CSER874
DSER243

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER320
CSER320
DSER320
BSER320

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08962
ChainResidueDetails
ASER351
CSER351
DSER351
BSER351

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:O35219
ChainResidueDetails
AARG1014
CARG1014
DARG1014
BARG1014

site_idSWS_FT_FI16
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12063277
ChainResidueDetails
AASN598
CASN598
DASN598
BASN598

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PDB entries from 2024-07-24

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