Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8IO4

Herg1a-herg1b open state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003064	biological_process	regulation of heart rate by hormone
A	0005216	molecular_function	monoatomic ion channel activity
A	0005242	molecular_function	inward rectifier potassium channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005251	molecular_function	delayed rectifier potassium channel activity
A	0005267	molecular_function	potassium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0009986	cellular_component	cell surface
A	0016020	cellular_component	membrane
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0055075	biological_process	potassium ion homeostasis
A	0055085	biological_process	transmembrane transport
A	0060048	biological_process	cardiac muscle contraction
A	0060306	biological_process	regulation of membrane repolarization
A	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071805	biological_process	potassium ion transmembrane transport
A	0086005	biological_process	ventricular cardiac muscle cell action potential
A	0086009	biological_process	membrane repolarization
A	0086010	biological_process	membrane depolarization during action potential
A	0086011	biological_process	membrane repolarization during action potential
A	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
A	0086091	biological_process	regulation of heart rate by cardiac conduction
A	0097110	molecular_function	scaffold protein binding
A	0097623	biological_process	potassium ion export across plasma membrane
A	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1901380	biological_process	negative regulation of potassium ion transmembrane transport
A	1901381	biological_process	positive regulation of potassium ion transmembrane transport
A	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
A	1902937	cellular_component	inward rectifier potassium channel complex
A	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
A	1990573	biological_process	potassium ion import across plasma membrane
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003064	biological_process	regulation of heart rate by hormone
B	0005216	molecular_function	monoatomic ion channel activity
B	0005242	molecular_function	inward rectifier potassium channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0005251	molecular_function	delayed rectifier potassium channel activity
B	0005267	molecular_function	potassium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0009986	cellular_component	cell surface
B	0016020	cellular_component	membrane
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0055075	biological_process	potassium ion homeostasis
B	0055085	biological_process	transmembrane transport
B	0060048	biological_process	cardiac muscle contraction
B	0060306	biological_process	regulation of membrane repolarization
B	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0071805	biological_process	potassium ion transmembrane transport
B	0086005	biological_process	ventricular cardiac muscle cell action potential
B	0086009	biological_process	membrane repolarization
B	0086010	biological_process	membrane depolarization during action potential
B	0086011	biological_process	membrane repolarization during action potential
B	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
B	0086091	biological_process	regulation of heart rate by cardiac conduction
B	0097110	molecular_function	scaffold protein binding
B	0097623	biological_process	potassium ion export across plasma membrane
B	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
B	1901379	biological_process	regulation of potassium ion transmembrane transport
B	1901380	biological_process	negative regulation of potassium ion transmembrane transport
B	1901381	biological_process	positive regulation of potassium ion transmembrane transport
B	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
B	1902937	cellular_component	inward rectifier potassium channel complex
B	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
B	1990573	biological_process	potassium ion import across plasma membrane
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0003064	biological_process	regulation of heart rate by hormone
C	0005216	molecular_function	monoatomic ion channel activity
C	0005242	molecular_function	inward rectifier potassium channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005251	molecular_function	delayed rectifier potassium channel activity
C	0005267	molecular_function	potassium channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0009986	cellular_component	cell surface
C	0016020	cellular_component	membrane
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0055075	biological_process	potassium ion homeostasis
C	0055085	biological_process	transmembrane transport
C	0060048	biological_process	cardiac muscle contraction
C	0060306	biological_process	regulation of membrane repolarization
C	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0071805	biological_process	potassium ion transmembrane transport
C	0086005	biological_process	ventricular cardiac muscle cell action potential
C	0086009	biological_process	membrane repolarization
C	0086010	biological_process	membrane depolarization during action potential
C	0086011	biological_process	membrane repolarization during action potential
C	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
C	0086091	biological_process	regulation of heart rate by cardiac conduction
C	0097110	molecular_function	scaffold protein binding
C	0097623	biological_process	potassium ion export across plasma membrane
C	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
C	1901379	biological_process	regulation of potassium ion transmembrane transport
C	1901380	biological_process	negative regulation of potassium ion transmembrane transport
C	1901381	biological_process	positive regulation of potassium ion transmembrane transport
C	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
C	1902937	cellular_component	inward rectifier potassium channel complex
C	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
C	1990573	biological_process	potassium ion import across plasma membrane
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0003064	biological_process	regulation of heart rate by hormone
D	0005216	molecular_function	monoatomic ion channel activity
D	0005242	molecular_function	inward rectifier potassium channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0005251	molecular_function	delayed rectifier potassium channel activity
D	0005267	molecular_function	potassium channel activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0009986	cellular_component	cell surface
D	0016020	cellular_component	membrane
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034702	cellular_component	monoatomic ion channel complex
D	0042391	biological_process	regulation of membrane potential
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0055075	biological_process	potassium ion homeostasis
D	0055085	biological_process	transmembrane transport
D	0060048	biological_process	cardiac muscle contraction
D	0060306	biological_process	regulation of membrane repolarization
D	0060307	biological_process	regulation of ventricular cardiac muscle cell membrane repolarization
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	0071805	biological_process	potassium ion transmembrane transport
D	0086005	biological_process	ventricular cardiac muscle cell action potential
D	0086009	biological_process	membrane repolarization
D	0086010	biological_process	membrane depolarization during action potential
D	0086011	biological_process	membrane repolarization during action potential
D	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
D	0086091	biological_process	regulation of heart rate by cardiac conduction
D	0097110	molecular_function	scaffold protein binding
D	0097623	biological_process	potassium ion export across plasma membrane
D	0098915	biological_process	membrane repolarization during ventricular cardiac muscle cell action potential
D	1901379	biological_process	regulation of potassium ion transmembrane transport
D	1901380	biological_process	negative regulation of potassium ion transmembrane transport
D	1901381	biological_process	positive regulation of potassium ion transmembrane transport
D	1902282	molecular_function	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
D	1902937	cellular_component	inward rectifier potassium channel complex
D	1903765	biological_process	negative regulation of potassium ion export across plasma membrane
D	1990573	biological_process	potassium ion import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	112
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	80
Details	Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	400
Details	Region: {"description":"cNMP-binding domain","evidences":[{"source":"PROSITE-ProRule","id":"PRU00060","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	20
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"Q63472","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)