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8IMY

Cryo-EM structure of GPI-T (inactive mutant) with GPI and proULBP2, a proprotein substrate

Functional Information from GO Data
ChainGOidnamespacecontents
D0001916biological_processpositive regulation of T cell mediated cytotoxicity
D0002376biological_processimmune system process
D0002476biological_processantigen processing and presentation of endogenous peptide antigen via MHC class Ib
D0002486biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005783cellular_componentendoplasmic reticulum
D0005886cellular_componentplasma membrane
D0006955biological_processimmune response
D0007165biological_processsignal transduction
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0030101biological_processnatural killer cell activation
D0042267biological_processnatural killer cell mediated cytotoxicity
D0043231cellular_componentintracellular membrane-bounded organelle
D0046703molecular_functionnatural killer cell lectin-like receptor binding
D0048018molecular_functionreceptor ligand activity
D0098552cellular_componentside of membrane
G0003923molecular_functionGPI-anchor transamidase activity
G0005515molecular_functionprotein binding
G0005739cellular_componentmitochondrion
G0005783cellular_componentendoplasmic reticulum
G0005789cellular_componentendoplasmic reticulum membrane
G0005813cellular_componentcentrosome
G0005829cellular_componentcytosol
G0006091biological_processgeneration of precursor metabolites and energy
G0006506biological_processGPI anchor biosynthetic process
G0006621biological_processprotein retention in ER lumen
G0008218biological_processbioluminescence
G0015631molecular_functiontubulin binding
G0016020cellular_componentmembrane
G0016255biological_processattachment of GPI anchor to protein
G0034235molecular_functionGPI anchor binding
G0042765cellular_componentGPI-anchor transamidase complex
G0065003biological_processprotein-containing complex assembly
K0003923molecular_functionGPI-anchor transamidase activity
K0006508biological_processproteolysis
K0008218biological_processbioluminescence
K0008233molecular_functionpeptidase activity
K0016255biological_processattachment of GPI anchor to protein
K0042765cellular_componentGPI-anchor transamidase complex
S0005515molecular_functionprotein binding
S0005783cellular_componentendoplasmic reticulum
S0005789cellular_componentendoplasmic reticulum membrane
S0006091biological_processgeneration of precursor metabolites and energy
S0006506biological_processGPI anchor biosynthetic process
S0008218biological_processbioluminescence
S0016020cellular_componentmembrane
S0016255biological_processattachment of GPI anchor to protein
S0042765cellular_componentGPI-anchor transamidase complex
T0006091biological_processgeneration of precursor metabolites and energy
T0008218biological_processbioluminescence
T0016255biological_processattachment of GPI anchor to protein
T0042765cellular_componentGPI-anchor transamidase complex
U0005515molecular_functionprotein binding
U0005783cellular_componentendoplasmic reticulum
U0005789cellular_componentendoplasmic reticulum membrane
U0005886cellular_componentplasma membrane
U0006091biological_processgeneration of precursor metabolites and energy
U0006506biological_processGPI anchor biosynthetic process
U0008218biological_processbioluminescence
U0016020cellular_componentmembrane
U0016255biological_processattachment of GPI anchor to protein
U0034235molecular_functionGPI anchor binding
U0042765cellular_componentGPI-anchor transamidase complex
U0046425biological_processregulation of receptor signaling pathway via JAK-STAT
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsLIPID: GPI-anchor amidated serine => ECO:0000305|PubMed:11239445, ECO:0000305|PubMed:11444831
ChainResidueDetails
DSER216
SLEU542-ASP555
ULEU188-LEU208
ULEU237-VAL257
UGLY259-ALA279
USER286-ILE306
UILE313-GLY333
UILE355-LEU375
UPHE386-PHE406

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
DASN68
DASN82
GVAL428-GLY448
GALA459-PRO479
GMET496-THR516
GTYR544-TRP564
GPHE600-TRP620

site_idSWS_FT_FI3
Number of Residues480
DetailsTOPO_DOM: Lumenal => ECO:0000255
ChainResidueDetails
SGLU40-ALA520
UGLY515
GASN517-LEU543
GLYS621

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
SASN267
SASN370

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: 2,3-didehydrotyrosine => ECO:0000250|UniProtKB:Q9U6Y8
ChainResidueDetails
STYR634
TASN327

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: 2-iminomethyl-5-imidazolinone (Gln-Gly) => ECO:0000250|UniProtKB:Q9U6Y8
ChainResidueDetails
SGLN633
SGLY635

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: 2-iminomethyl-5-imidazolinone (Gln-Gly) => ECO:0000250|UniProtKB:Q9U6Y8
ChainResidueDetails
TGLN656
TGLY658

222415

PDB entries from 2024-07-10

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