8IJ5

Cryo-EM structure of Integrin AVB3

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0007155	biological_process	cell adhesion
E	0008305	cellular_component	integrin complex

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CrCgpGwlGSqC

Chain	Residue	Details
B	CYS486-CYS497

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site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CrCgpGWlgsq....C

Chain	Residue	Details
B	CYS486-CYS497

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:19704023, ECO:0000269|PubMed:28117447, ECO:0007744|PDB:3IJE, ECO:0007744|PDB:5FFG

Chain	Residue	Details
E	ASP260
E	ASP322
E	ASP379
E	ASP381
E	ASP383
E	PHE385
E	ASP387
E	ASP443
E	ASP445
E	ASN447
E	TYR449
E	ASN262
E	ASP451
E	ASP264
E	ILE266
E	ASP268
E	ASP314
E	ASN316
E	ASP318
E	TYR320

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:19704023, ECO:0000269|PubMed:28117447, ECO:0007744|PDB:3IJE

Chain	Residue	Details
E	ASN74

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19704023, ECO:0000269|PubMed:28117447, ECO:0007744|PDB:3IJE

Chain	Residue	Details
E	ASN290
E	ASN296
E	ASN488
E	ASN554

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19704023, ECO:0000269|PubMed:28117447, ECO:0007744|PDB:3IJE

Chain	Residue	Details
E	ASN615
B	ASN241
B	ASP243
B	PRO245

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: in LIMBS binding site => ECO:0007744|PDB:4G1M

Chain	Residue	Details
B	ASP277

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site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE

Chain	Residue	Details
B	MET361

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE

Chain	Residue	Details
B	ASN125

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site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE

Chain	Residue	Details
B	ASN346
B	ASN397

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site_id	SWS_FT_FI9
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:3IJE

Chain	Residue	Details
B	ASN478

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