8IHO

Crystal structures of SARS-CoV-2 papain-like protease in complex with covalent inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
C	0006508	biological_process	proteolysis
C	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	74
Details	ZN_FING: C4-type => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
A	CYS189-CYS226
C	CYS189-CYS226

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:32726803

Chain	Residue	Details
A	CYS111
C	CYS111

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site_id	SWS_FT_FI3
Number of Residues	4
Details	ACT_SITE: For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
A	HIS272
A	ASP286
C	HIS272
C	ASP286

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
A	CYS189
A	CYS192
A	CYS224
A	CYS226
C	CYS189
C	CYS192
C	CYS224
C	CYS226

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