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8IEK

Cryo-EM structure of ATP13A2 in the E1-ATP state

Functional Information from GO Data
ChainGOidnamespacecontents
P0000166molecular_functionnucleotide binding
P0000421cellular_componentautophagosome membrane
P0005215molecular_functiontransporter activity
P0005515molecular_functionprotein binding
P0005524molecular_functionATP binding
P0005764cellular_componentlysosome
P0005765cellular_componentlysosomal membrane
P0005768cellular_componentendosome
P0005770cellular_componentlate endosome
P0005771cellular_componentmultivesicular body
P0005776cellular_componentautophagosome
P0006874biological_processintracellular calcium ion homeostasis
P0006879biological_processintracellular iron ion homeostasis
P0006882biological_processintracellular zinc ion homeostasis
P0006914biological_processautophagy
P0007041biological_processlysosomal transport
P0008270molecular_functionzinc ion binding
P0008289molecular_functionlipid binding
P0010628biological_processpositive regulation of gene expression
P0010821biological_processregulation of mitochondrion organization
P0012506cellular_componentvesicle membrane
P0015203molecular_functionpolyamine transmembrane transporter activity
P0015417molecular_functionABC-type polyamine transporter activity
P0015662molecular_functionP-type ion transporter activity
P0016020cellular_componentmembrane
P0016241biological_processregulation of macroautophagy
P0016243biological_processregulation of autophagosome size
P0016887molecular_functionATP hydrolysis activity
P0019829molecular_functionATPase-coupled monoatomic cation transmembrane transporter activity
P0030003biological_processintracellular monoatomic cation homeostasis
P0030133cellular_componenttransport vesicle
P0030145molecular_functionmanganese ion binding
P0031902cellular_componentlate endosome membrane
P0031982cellular_componentvesicle
P0032585cellular_componentmultivesicular body membrane
P0033157biological_processregulation of intracellular protein transport
P0034220biological_processmonoatomic ion transmembrane transport
P0034599biological_processcellular response to oxidative stress
P0043005cellular_componentneuron projection
P0043025cellular_componentneuronal cell body
P0043202cellular_componentlysosomal lumen
P0043523biological_processregulation of neuron apoptotic process
P0046777biological_processprotein autophosphorylation
P0046872molecular_functionmetal ion binding
P0050714biological_processpositive regulation of protein secretion
P0052548biological_processregulation of endopeptidase activity
P0055085biological_processtransmembrane transport
P0055088biological_processlipid homeostasis
P0061462biological_processprotein localization to lysosome
P0061909biological_processautophagosome-lysosome fusion
P0070300molecular_functionphosphatidic acid binding
P0071287biological_processcellular response to manganese ion
P0071294biological_processcellular response to zinc ion
P0080025molecular_functionphosphatidylinositol-3,5-bisphosphate binding
P0097734biological_processextracellular exosome biogenesis
P0098655biological_processmonoatomic cation transmembrane transport
P0140358molecular_functionP-type transmembrane transporter activity
P1900180biological_processregulation of protein localization to nucleus
P1902047biological_processpolyamine transmembrane transport
P1903135molecular_functioncupric ion binding
P1903146biological_processregulation of autophagy of mitochondrion
P1903543biological_processpositive regulation of exosomal secretion
P1903710biological_processspermine transmembrane transport
P1904714biological_processregulation of chaperone-mediated autophagy
P1905037biological_processautophagosome organization
P1905165biological_processregulation of lysosomal protein catabolic process
P1905166biological_processnegative regulation of lysosomal protein catabolic process
P1990938biological_processpeptidyl-aspartic acid autophosphorylation
P2000152biological_processregulation of ubiquitin-specific protease activity
Functional Information from PROSITE/UniProt
site_idPS00154
Number of Residues7
DetailsATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT
ChainResidueDetails
PASP513-THR519

site_idPS01229
Number of Residues23
DetailsCOF_2 Hypothetical cof family signature 2. CGDGaNDcgaLkaAdvGisLsqA
ChainResidueDetails
PCYS876-ALA898

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues873
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:26134396
ChainResidueDetails
PMET1-PRO44
PARG66-GLU235
PLYS277-LYS427
PGLN485-SER930
PSER979-GLY994
PPRO1070-PRO1080
PASP1139-ARG1180

site_idSWS_FT_FI2
Number of Residues20
DetailsINTRAMEM: INTRAMEM => ECO:0000255
ChainResidueDetails
PTRP45-PHE65

site_idSWS_FT_FI3
Number of Residues196
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
PALA236-ALA253
PLEU1118-LEU1138
PTYR257-TYR276
PPHE428-TYR448
PLEU464-ALA484
PPHE931-LEU951
PLEU958-MET978
PALA995-VAL1015
PVAL1049-ALA1069
PPHE1081-LEU1101

site_idSWS_FT_FI4
Number of Residues68
DetailsTOPO_DOM: Lumenal => ECO:0000305|PubMed:26134396
ChainResidueDetails
PASP254-TYR256
PARG449-ASP463
PTYR952-ASN957
PGLN1016-THR1048
PLEU1102-LYS1117

site_idSWS_FT_FI5
Number of Residues1
DetailsACT_SITE: 4-aspartylphosphate intermediate => ECO:0000269|PubMed:26134396
ChainResidueDetails
PASP513

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
PASP878
PASP882

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
PSER151

site_idSWS_FT_FI8
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26134396
ChainResidueDetails
PASN1033

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
PASN1110

221371

PDB entries from 2024-06-19

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