8IBB

Respiratory complex Membrane domain of CI, focus-refined of type IB, Wild type mouse under cold temperature

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0003954	molecular_function	NADH dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0009060	biological_process	aerobic respiration
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0019826	molecular_function	oxygen sensor activity
D	0022008	biological_process	neurogenesis
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D	0042063	biological_process	gliogenesis
D	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045271	cellular_component	respiratory chain complex I
D	0046872	molecular_function	metal ion binding
D	0048038	molecular_function	quinone binding
D	0051287	molecular_function	NAD binding
D	0051536	molecular_function	iron-sulfur cluster binding
D	0051539	molecular_function	4 iron, 4 sulfur cluster binding
D	0061351	biological_process	neural precursor cell proliferation
D	0071453	biological_process	cellular response to oxygen levels
D	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0009060	biological_process	aerobic respiration
J	0016020	cellular_component	membrane
J	0032981	biological_process	mitochondrial respiratory chain complex I assembly
J	0035094	biological_process	response to nicotine
J	0042220	biological_process	response to cocaine
J	0042542	biological_process	response to hydrogen peroxide
J	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
J	0045271	cellular_component	respiratory chain complex I
J	1902600	biological_process	proton transmembrane transport
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0009060	biological_process	aerobic respiration
K	0016020	cellular_component	membrane
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
K	0045271	cellular_component	respiratory chain complex I
K	1902600	biological_process	proton transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0009060	biological_process	aerobic respiration
L	0015990	biological_process	electron transport coupled proton transport
L	0016020	cellular_component	membrane
L	0032981	biological_process	mitochondrial respiratory chain complex I assembly
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
L	0045271	cellular_component	respiratory chain complex I
M	0001666	biological_process	response to hypoxia
M	0001701	biological_process	in utero embryonic development
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009060	biological_process	aerobic respiration
M	0015990	biological_process	electron transport coupled proton transport
M	0016020	cellular_component	membrane
M	0021549	biological_process	cerebellum development
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0035094	biological_process	response to nicotine
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
M	0045271	cellular_component	respiratory chain complex I
M	0045471	biological_process	response to ethanol
M	0048039	molecular_function	ubiquinone binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
N	0045271	cellular_component	respiratory chain complex I
N	0072593	biological_process	reactive oxygen species metabolic process
N	1902600	biological_process	proton transmembrane transport
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005759	cellular_component	mitochondrial matrix
O	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
O	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
O	0009060	biological_process	aerobic respiration
O	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
O	0043209	cellular_component	myelin sheath
O	0045271	cellular_component	respiratory chain complex I
O	1902600	biological_process	proton transmembrane transport
U	0000035	molecular_function	acyl binding
U	0000036	molecular_function	acyl carrier activity
U	0005198	molecular_function	structural molecule activity
U	0005654	cellular_component	nucleoplasm
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006629	biological_process	lipid metabolic process
U	0006631	biological_process	fatty acid metabolic process
U	0006633	biological_process	fatty acid biosynthetic process
U	0009060	biological_process	aerobic respiration
U	0016226	biological_process	iron-sulfur cluster assembly
U	0031966	cellular_component	mitochondrial membrane
U	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
U	0044571	biological_process	[2Fe-2S] cluster assembly
U	0045271	cellular_component	respiratory chain complex I
U	0099128	cellular_component	mitochondrial [2Fe-2S] assembly complex
U	0140978	molecular_function	mitochondrial large ribosomal subunit binding
U	1990229	cellular_component	iron-sulfur cluster assembly complex
X	0005739	cellular_component	mitochondrion
X	0005743	cellular_component	mitochondrial inner membrane
X	0005758	cellular_component	mitochondrial intermembrane space
X	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
X	0009060	biological_process	aerobic respiration
X	0016020	cellular_component	membrane
X	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
X	0044877	molecular_function	protein-containing complex binding
X	0045271	cellular_component	respiratory chain complex I
Y	0005739	cellular_component	mitochondrion
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Y	0016020	cellular_component	membrane
Y	0045271	cellular_component	respiratory chain complex I
c	0003674	molecular_function	molecular_function
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0009060	biological_process	aerobic respiration
c	0016020	cellular_component	membrane
c	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
c	0045271	cellular_component	respiratory chain complex I
d	0005737	cellular_component	cytoplasm
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0009060	biological_process	aerobic respiration
d	0010918	biological_process	positive regulation of mitochondrial membrane potential
d	0016020	cellular_component	membrane
d	0032981	biological_process	mitochondrial respiratory chain complex I assembly
d	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
d	0045271	cellular_component	respiratory chain complex I
d	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
d	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
d	2001171	biological_process	positive regulation of ATP biosynthetic process
e	0003674	molecular_function	molecular_function
e	0005739	cellular_component	mitochondrion
e	0005743	cellular_component	mitochondrial inner membrane
e	0005758	cellular_component	mitochondrial intermembrane space
e	0009060	biological_process	aerobic respiration
e	0016020	cellular_component	membrane
e	0032981	biological_process	mitochondrial respiratory chain complex I assembly
e	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
e	0045271	cellular_component	respiratory chain complex I
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0009060	biological_process	aerobic respiration
f	0016020	cellular_component	membrane
f	0016607	cellular_component	nuclear speck
f	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
f	0045271	cellular_component	respiratory chain complex I
g	0003674	molecular_function	molecular_function
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0009060	biological_process	aerobic respiration
g	0016020	cellular_component	membrane
g	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
g	0045271	cellular_component	respiratory chain complex I
h	0003674	molecular_function	molecular_function
h	0005654	cellular_component	nucleoplasm
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0009060	biological_process	aerobic respiration
h	0016020	cellular_component	membrane
h	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
h	0045271	cellular_component	respiratory chain complex I
i	0005654	cellular_component	nucleoplasm
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0009060	biological_process	aerobic respiration
i	0016020	cellular_component	membrane
i	0031966	cellular_component	mitochondrial membrane
i	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
i	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
i	0045271	cellular_component	respiratory chain complex I
j	0003674	molecular_function	molecular_function
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0009060	biological_process	aerobic respiration
j	0016020	cellular_component	membrane
j	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
j	0045271	cellular_component	respiratory chain complex I
k	0003674	molecular_function	molecular_function
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0009060	biological_process	aerobic respiration
k	0016020	cellular_component	membrane
k	0022900	biological_process	electron transport chain
k	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
k	0045271	cellular_component	respiratory chain complex I
l	0003674	molecular_function	molecular_function
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0009060	biological_process	aerobic respiration
l	0016020	cellular_component	membrane
l	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
l	0045271	cellular_component	respiratory chain complex I
m	0003674	molecular_function	molecular_function
m	0005654	cellular_component	nucleoplasm
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0009060	biological_process	aerobic respiration
m	0016020	cellular_component	membrane
m	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
m	0045271	cellular_component	respiratory chain complex I
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0009060	biological_process	aerobic respiration
n	0016020	cellular_component	membrane
n	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
n	0045271	cellular_component	respiratory chain complex I
o	0003674	molecular_function	molecular_function
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005758	cellular_component	mitochondrial intermembrane space
o	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
o	0009060	biological_process	aerobic respiration
o	0016020	cellular_component	membrane
o	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
o	0045271	cellular_component	respiratory chain complex I
o	1902600	biological_process	proton transmembrane transport
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0009060	biological_process	aerobic respiration
p	0016020	cellular_component	membrane
p	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
p	0045271	cellular_component	respiratory chain complex I

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
U	ASP107-MET122

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site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
U	ASP132-ILE144

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site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
D	LEU116-LYS127

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
h	PHE73-ILE93
N	LEU324-ILE344
M	MET350-PRO370
M	THR392-ILE412
M	LEU434-ILE454
L	LEU457-ILE477
L	MET482-LEU502
L	LEU586-LEU606
N	ASN25-ILE45
N	ALA56-LEU76
N	GLY92-TRP114
N	LEU149-ASN171
N	ILE178-PRO198
N	LEU200-MET220
N	LEU241-LEU261
N	ASN274-THR294

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258

Chain	Residue	Details
U	SER112

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
O	LYS285
k	HIS13
k	HIS15

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337

Chain	Residue	Details
k	LYS29
k	LYS40

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