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8IB2

Structure of mammalian spectrin-actin junctional complex of membrane skeleton, Pointed-end segment, headpiece domain of dematin optimized

Functional Information from GO Data
ChainGOidnamespacecontents
50003779molecular_functionactin binding
50005102molecular_functionsignaling receptor binding
50005737cellular_componentcytoplasm
50005790cellular_componentsmooth endoplasmic reticulum
50005829cellular_componentcytosol
50005856cellular_componentcytoskeleton
50005884cellular_componentactin filament
50005886cellular_componentplasma membrane
50007010biological_processcytoskeleton organization
50008360biological_processregulation of cell shape
50010591biological_processregulation of lamellipodium assembly
50010763biological_processpositive regulation of fibroblast migration
50010812biological_processnegative regulation of cell-substrate adhesion
50014069cellular_componentpostsynaptic density
50014731cellular_componentspectrin-associated cytoskeleton
50015629cellular_componentactin cytoskeleton
50016020cellular_componentmembrane
50030032biological_processlamellipodium assembly
50030036biological_processactin cytoskeleton organization
50030507molecular_functionspectrin binding
50030863cellular_componentcortical cytoskeleton
50031095cellular_componentplatelet dense tubular network membrane
50031253cellular_componentcell projection membrane
50031410cellular_componentcytoplasmic vesicle
50032956biological_processregulation of actin cytoskeleton organization
50042995cellular_componentcell projection
50045202cellular_componentsynapse
50048471cellular_componentperinuclear region of cytoplasm
50048821biological_processerythrocyte development
50051015molecular_functionactin filament binding
50051489biological_processregulation of filopodium assembly
50051563biological_processsmooth endoplasmic reticulum calcium ion homeostasis
50051693biological_processactin filament capping
50051895biological_processnegative regulation of focal adhesion assembly
50065003biological_processprotein-containing complex assembly
50071320biological_processcellular response to cAMP
50071786biological_processendoplasmic reticulum tubular network organization
50090303biological_processpositive regulation of wound healing
50090315biological_processnegative regulation of protein targeting to membrane
51900025biological_processnegative regulation of substrate adhesion-dependent cell spreading
B0000166molecular_functionnucleotide binding
B0000786cellular_componentnucleosome
B0001738biological_processmorphogenesis of a polarized epithelium
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0005911cellular_componentcell-cell junction
B0005912cellular_componentadherens junction
B0005925cellular_componentfocal adhesion
B0007163biological_processestablishment or maintenance of cell polarity
B0007409biological_processaxonogenesis
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0019894molecular_functionkinesin binding
B0019901molecular_functionprotein kinase binding
B0030027cellular_componentlamellipodium
B0030235molecular_functionnitric-oxide synthase regulator activity
B0030424cellular_componentaxon
B0030863cellular_componentcortical cytoskeleton
B0030957molecular_functionTat protein binding
B0032991cellular_componentprotein-containing complex
B0034333biological_processadherens junction assembly
B0035267cellular_componentNuA4 histone acetyltransferase complex
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0042802molecular_functionidentical protein binding
B0043296cellular_componentapical junction complex
B0044305cellular_componentcalyx of Held
B0045176biological_processapical protein localization
B0045202cellular_componentsynapse
B0048870biological_processcell motility
B0050998molecular_functionnitric-oxide synthase binding
B0051621biological_processregulation of norepinephrine uptake
B0051726biological_processregulation of cell cycle
B0070160cellular_componenttight junction
B0071896biological_processprotein localization to adherens junction
B0072749biological_processcellular response to cytochalasin B
B0097433cellular_componentdense body
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098871cellular_componentpostsynaptic actin cytoskeleton
B0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
B0098974biological_processpostsynaptic actin cytoskeleton organization
B0098978cellular_componentglutamatergic synapse
B0141108molecular_functiontransporter regulator activity
B0150111biological_processregulation of transepithelial transport
B1900242biological_processregulation of synaptic vesicle endocytosis
B1903076biological_processregulation of protein localization to plasma membrane
B1905168biological_processpositive regulation of double-strand break repair via homologous recombination
B1990904cellular_componentribonucleoprotein complex
C0000166molecular_functionnucleotide binding
C0000786cellular_componentnucleosome
C0001738biological_processmorphogenesis of a polarized epithelium
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005903cellular_componentbrush border
C0005911cellular_componentcell-cell junction
C0005912cellular_componentadherens junction
C0005925cellular_componentfocal adhesion
C0007163biological_processestablishment or maintenance of cell polarity
C0007409biological_processaxonogenesis
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0019894molecular_functionkinesin binding
C0019901molecular_functionprotein kinase binding
C0030027cellular_componentlamellipodium
C0030235molecular_functionnitric-oxide synthase regulator activity
C0030424cellular_componentaxon
C0030863cellular_componentcortical cytoskeleton
C0030957molecular_functionTat protein binding
C0032991cellular_componentprotein-containing complex
C0034333biological_processadherens junction assembly
C0035267cellular_componentNuA4 histone acetyltransferase complex
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042802molecular_functionidentical protein binding
C0043296cellular_componentapical junction complex
C0044305cellular_componentcalyx of Held
C0045176biological_processapical protein localization
C0045202cellular_componentsynapse
C0048870biological_processcell motility
C0050998molecular_functionnitric-oxide synthase binding
C0051621biological_processregulation of norepinephrine uptake
C0051726biological_processregulation of cell cycle
C0070160cellular_componenttight junction
C0071896biological_processprotein localization to adherens junction
C0072749biological_processcellular response to cytochalasin B
C0097433cellular_componentdense body
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098871cellular_componentpostsynaptic actin cytoskeleton
C0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
C0098974biological_processpostsynaptic actin cytoskeleton organization
C0098978cellular_componentglutamatergic synapse
C0141108molecular_functiontransporter regulator activity
C0150111biological_processregulation of transepithelial transport
C1900242biological_processregulation of synaptic vesicle endocytosis
C1903076biological_processregulation of protein localization to plasma membrane
C1905168biological_processpositive regulation of double-strand break repair via homologous recombination
C1990904cellular_componentribonucleoprotein complex
D0000166molecular_functionnucleotide binding
D0000786cellular_componentnucleosome
D0001738biological_processmorphogenesis of a polarized epithelium
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0005886cellular_componentplasma membrane
D0005903cellular_componentbrush border
D0005911cellular_componentcell-cell junction
D0005912cellular_componentadherens junction
D0005925cellular_componentfocal adhesion
D0007163biological_processestablishment or maintenance of cell polarity
D0007409biological_processaxonogenesis
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0019894molecular_functionkinesin binding
D0019901molecular_functionprotein kinase binding
D0030027cellular_componentlamellipodium
D0030235molecular_functionnitric-oxide synthase regulator activity
D0030424cellular_componentaxon
D0030863cellular_componentcortical cytoskeleton
D0030957molecular_functionTat protein binding
D0032991cellular_componentprotein-containing complex
D0034333biological_processadherens junction assembly
D0035267cellular_componentNuA4 histone acetyltransferase complex
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0042802molecular_functionidentical protein binding
D0043296cellular_componentapical junction complex
D0044305cellular_componentcalyx of Held
D0045176biological_processapical protein localization
D0045202cellular_componentsynapse
D0048870biological_processcell motility
D0050998molecular_functionnitric-oxide synthase binding
D0051621biological_processregulation of norepinephrine uptake
D0051726biological_processregulation of cell cycle
D0070160cellular_componenttight junction
D0071896biological_processprotein localization to adherens junction
D0072749biological_processcellular response to cytochalasin B
D0097433cellular_componentdense body
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098871cellular_componentpostsynaptic actin cytoskeleton
D0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
D0098974biological_processpostsynaptic actin cytoskeleton organization
D0098978cellular_componentglutamatergic synapse
D0141108molecular_functiontransporter regulator activity
D0150111biological_processregulation of transepithelial transport
D1900242biological_processregulation of synaptic vesicle endocytosis
D1903076biological_processregulation of protein localization to plasma membrane
D1905168biological_processpositive regulation of double-strand break repair via homologous recombination
D1990904cellular_componentribonucleoprotein complex
E0000166molecular_functionnucleotide binding
E0000786cellular_componentnucleosome
E0001738biological_processmorphogenesis of a polarized epithelium
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005884cellular_componentactin filament
E0005886cellular_componentplasma membrane
E0005903cellular_componentbrush border
E0005911cellular_componentcell-cell junction
E0005912cellular_componentadherens junction
E0005925cellular_componentfocal adhesion
E0007163biological_processestablishment or maintenance of cell polarity
E0007409biological_processaxonogenesis
E0015629cellular_componentactin cytoskeleton
E0016020cellular_componentmembrane
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0019894molecular_functionkinesin binding
E0019901molecular_functionprotein kinase binding
E0030027cellular_componentlamellipodium
E0030235molecular_functionnitric-oxide synthase regulator activity
E0030424cellular_componentaxon
E0030863cellular_componentcortical cytoskeleton
E0030957molecular_functionTat protein binding
E0032991cellular_componentprotein-containing complex
E0034333biological_processadherens junction assembly
E0035267cellular_componentNuA4 histone acetyltransferase complex
E0036464cellular_componentcytoplasmic ribonucleoprotein granule
E0042802molecular_functionidentical protein binding
E0043296cellular_componentapical junction complex
E0044305cellular_componentcalyx of Held
E0045176biological_processapical protein localization
E0045202cellular_componentsynapse
E0048870biological_processcell motility
E0050998molecular_functionnitric-oxide synthase binding
E0051621biological_processregulation of norepinephrine uptake
E0051726biological_processregulation of cell cycle
E0070160cellular_componenttight junction
E0071896biological_processprotein localization to adherens junction
E0072749biological_processcellular response to cytochalasin B
E0097433cellular_componentdense body
E0098685cellular_componentSchaffer collateral - CA1 synapse
E0098871cellular_componentpostsynaptic actin cytoskeleton
E0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
E0098974biological_processpostsynaptic actin cytoskeleton organization
E0098978cellular_componentglutamatergic synapse
E0141108molecular_functiontransporter regulator activity
E0150111biological_processregulation of transepithelial transport
E1900242biological_processregulation of synaptic vesicle endocytosis
E1903076biological_processregulation of protein localization to plasma membrane
E1905168biological_processpositive regulation of double-strand break repair via homologous recombination
E1990904cellular_componentribonucleoprotein complex
F0000166molecular_functionnucleotide binding
F0000786cellular_componentnucleosome
F0001738biological_processmorphogenesis of a polarized epithelium
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005884cellular_componentactin filament
F0005886cellular_componentplasma membrane
F0005903cellular_componentbrush border
F0005911cellular_componentcell-cell junction
F0005912cellular_componentadherens junction
F0005925cellular_componentfocal adhesion
F0007163biological_processestablishment or maintenance of cell polarity
F0007409biological_processaxonogenesis
F0015629cellular_componentactin cytoskeleton
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0019894molecular_functionkinesin binding
F0019901molecular_functionprotein kinase binding
F0030027cellular_componentlamellipodium
F0030235molecular_functionnitric-oxide synthase regulator activity
F0030424cellular_componentaxon
F0030863cellular_componentcortical cytoskeleton
F0030957molecular_functionTat protein binding
F0032991cellular_componentprotein-containing complex
F0034333biological_processadherens junction assembly
F0035267cellular_componentNuA4 histone acetyltransferase complex
F0036464cellular_componentcytoplasmic ribonucleoprotein granule
F0042802molecular_functionidentical protein binding
F0043296cellular_componentapical junction complex
F0044305cellular_componentcalyx of Held
F0045176biological_processapical protein localization
F0045202cellular_componentsynapse
F0048870biological_processcell motility
F0050998molecular_functionnitric-oxide synthase binding
F0051621biological_processregulation of norepinephrine uptake
F0051726biological_processregulation of cell cycle
F0070160cellular_componenttight junction
F0071896biological_processprotein localization to adherens junction
F0072749biological_processcellular response to cytochalasin B
F0097433cellular_componentdense body
F0098685cellular_componentSchaffer collateral - CA1 synapse
F0098871cellular_componentpostsynaptic actin cytoskeleton
F0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
F0098974biological_processpostsynaptic actin cytoskeleton organization
F0098978cellular_componentglutamatergic synapse
F0141108molecular_functiontransporter regulator activity
F0150111biological_processregulation of transepithelial transport
F1900242biological_processregulation of synaptic vesicle endocytosis
F1903076biological_processregulation of protein localization to plasma membrane
F1905168biological_processpositive regulation of double-strand break repair via homologous recombination
F1990904cellular_componentribonucleoprotein complex
Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
BTYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYDE
ChainResidueDetails
BTRP356-GLU364

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
BLEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsMOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P60709
ChainResidueDetails
BMET1
CMET1
DMET1
EMET1
FMET1

site_idSWS_FT_FI2
Number of Residues5
DetailsMOD_RES: N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed => ECO:0000250|UniProtKB:P60709
ChainResidueDetails
BASP2
CASP2
DASP2
EASP2
FASP2

site_idSWS_FT_FI3
Number of Residues10
DetailsMOD_RES: Methionine (R)-sulfoxide => ECO:0000250|UniProtKB:P60710
ChainResidueDetails
BMET44
FMET47
BMET47
CMET44
CMET47
DMET44
DMET47
EMET44
EMET47
FMET44

site_idSWS_FT_FI4
Number of Residues5
DetailsMOD_RES: Tele-methylhistidine => ECO:0000250|UniProtKB:P60710
ChainResidueDetails
BHIS73
CHIS73
DHIS73
EHIS73
FHIS73

site_idSWS_FT_FI5
Number of Residues5
DetailsMOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P60709
ChainResidueDetails
BLYS84
CLYS84
DLYS84
ELYS84
FLYS84

237423

PDB entries from 2025-06-11

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